{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,25]],"date-time":"2026-07-25T09:58:47Z","timestamp":1784973527457,"version":"3.55.0"},"reference-count":38,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2024,1,1]],"date-time":"2024-01-01T00:00:00Z","timestamp":1704067200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cancer Medicine"],"published-print":{"date-parts":[[2024,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Rituximab\u2010based combinations are the standard of care in diffuse large B\u2010cell lymphoma (DLBCL) and follicular lymphoma (FL). Despite being on market for over 20\u2009years, some of the adverse effects associated with the use of rituximab are not well known. Drug\u2010induced interstitial pneumonitis (DIP) is a potentially fatal complication of the treatment. Granulocyte colony\u2010stimulating factors (G\u2010CSF) are supportive agents commonly used to prevent neutropenic infections. G\u2010CSF are reported to have pulmonary toxicity, but the risk of DIP is greater when used in combination with other potentially pulmotoxic agents.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>In this retrospective study, we reported the G\u2010CSF use and risk of DIP in 234 DLBCL patients and 87 FL patients receiving R\u2010CHOP\u2010type immunochemotherapy.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>In 72% of patients, the treatment included a G\u2010CSF support. The overall incidence of treatment\u2010induced pneumonitis was 6.9% in this patient group. All the DIP cases (<jats:italic>n<\/jats:italic>\u2009=\u200916) were among patients receiving G\u2010CSF support (<jats:italic>p<\/jats:italic>\u2009=\u20090.03). Older age (over 60\u2009years) and higher disease stage (Ann Arbor 3\u20134) also increased the risk of DIP.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>These findings suggest that the use of G\u2010CSF increases the risk of DIP, when used in combination with rituximab\u2010containing regimen.<\/jats:p><\/jats:sec>","DOI":"10.1002\/cam4.6898","type":"journal-article","created":{"date-parts":[[2024,1,2]],"date-time":"2024-01-02T07:55:27Z","timestamp":1704182127000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Drug\u2010induced pneumonitis risk in diffuse large B\u2010cell\/follicular lymphoma patients treated with R\u2010CHOP\u2010like regimen is associated with the use of granulocyte colony\u2010stimulating growth factors"],"prefix":"10.1002","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0568-7422","authenticated-orcid":false,"given":"Elina","family":"Kaprio","sequence":"first","affiliation":[{"name":"Faculty of Health Medicine, Institute of Clinical Medicine University of Eastern Finland  Kuopio Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roosa","family":"Prusila","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Kuopio University Hospital  Kuopio Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6326-5979","authenticated-orcid":false,"given":"Susanna","family":"Tokola","sequence":"additional","affiliation":[{"name":"Department of Oncology and Radiotherapy, Medical Research Center Oulu University Hospital  Oulu Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Milla E. 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