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A Medline search was conducted for the years 1992\u20132015 to identify articles addressing early detection and management of <jats:styled-content style=\"fixed-case\">BCRL<\/jats:styled-content>. After an initial search, 127 articles were identified, with 13 of these studies focused on early intervention (three randomized (level of evidence 1), four prospective (level of evidence 2\u20133), six retrospective trials (level of evidence 4)). Data from two, small (<jats:italic>n<\/jats:italic>\u00a0=\u00a0185 cases), randomized trials with limited follow\u2010up demonstrated a benefit to early intervention (physiotherapy, manual lymphatic drainage) with regard to reducing the rate of chronic <jats:styled-content style=\"fixed-case\">BCRL<\/jats:styled-content> (&gt;50% reduction) with two additional studies underway (<jats:italic>n<\/jats:italic>\u00a0=\u00a01280). These findings were confirmed by larger prospective and retrospective series. Several studies were identified that demonstrate that newer diagnostic modalities (bioimpedance spectroscopy, perometry) have increased sensitivity allowing for the earlier detection of <jats:styled-content style=\"fixed-case\">BCRL<\/jats:styled-content>. Current data support the development of surveillance programs geared toward the early detection and management of <jats:styled-content style=\"fixed-case\">BCRL<\/jats:styled-content> in part due to newer, more sensitive diagnostic modalities.<\/jats:p>","DOI":"10.1002\/cam4.691","type":"journal-article","created":{"date-parts":[[2016,3,19]],"date-time":"2016-03-19T12:24:44Z","timestamp":1458390284000},"page":"1154-1162","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":138,"title":["The impact of early detection and intervention of breast cancer\u2010related lymphedema: a systematic review"],"prefix":"10.1002","volume":"5","author":[{"given":"Chirag","family":"Shah","sequence":"first","affiliation":[{"name":"Department of Radiation Oncology Taussig Cancer Institute Cleveland Clinic  Cleveland Ohio"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Douglas W.","family":"Arthur","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology Massey Cancer Center, Virginia Commonwealth University  Richmond, Virginia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Wazer","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology Tufts University School of Medicine  Boston Massachusetts"},{"name":"Department of Radiation Oncology Brown University  Providence Rhode Island"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Atif","family":"Khan","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology Robert Wood Johnson Medical School Rutgers University  New Brunswick New Jersey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sheila","family":"Ridner","sequence":"additional","affiliation":[{"name":"School of Nursing Vanderbilt University  Nashville Tennessee"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Frank","family":"Vicini","sequence":"additional","affiliation":[{"name":"Michigan Healthcare Professionals\/21<sup>st<\/sup> Century Oncology  Farmington Hills Michigan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2016,3,19]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.3322\/canjclin.57.1.43"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1634\/theoncologist.2011-0223"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(85)91807-0"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.breast.2010.05.015"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10549-014-2856-3"},{"key":"e_1_2_6_7_1","first-page":"586","volume-title":"Diseases of the breast","author":"McLaughlin S. 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