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People impacted by cancer (patients and caregivers) and healthcare professionals (HCPs) face distinct challenges in navigating the cBT and personalized treatment landscape. This review summarizes evidence regarding cBT\u2010related communication between people impacted by cancer and HCPs and identifies important avenues for future research in precision oncology.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A scoping review was conducted using records published in PubMed during January 2017\u2013August 2022, focusing on the breadth of topics on patient\u2010HCP communication and knowledge resources used by HCPs as guidance in cBT\u2010related communication. Data were extracted from records meeting inclusion criteria, and findings were summarized according to main topics.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The search identified 287 unique records and data were extracted from 42 records, including nine from expert input. Most records originated from the United States included patients with different types of cancer, and oncologists were the main HCPs. Patients' motivation for undergoing cBT and receiving results was generally high in different settings. However, patients' understanding of cBT\u2010related concepts was limited, and their knowledge and information preferences changed based on cBT implications and significance to family members. HCPs were valued by patients as a trusted source of information. Limited evidence was available on HCPs' information\u2010seeking behavior and factors influencing cBT\u2010related knowledge and confidence, often self\u2010reported as insufficient.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Patient education by knowledgeable and confident HCPs, information management and a caring patient\u2010HCP relationship communicating continuity of care regardless of cBT results are crucial to empower patients and shared decision\u2010making in precision oncology. More data on the process and structure of cBT\u2010related communication, distinction between and characterization of different timepoints of patient\u2010HCP interactions are needed.<\/jats:p><\/jats:sec>","DOI":"10.1002\/cam4.6913","type":"journal-article","created":{"date-parts":[[2024,2,1]],"date-time":"2024-02-01T07:54:26Z","timestamp":1706774066000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":17,"title":["Understanding communication between patients and healthcare professionals regarding comprehensive biomarker testing in precision oncology: A scoping review"],"prefix":"10.1002","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5569-1249","authenticated-orcid":false,"given":"Theresia","family":"Pichler","sequence":"first","affiliation":[{"name":"Department of Internal Medicine III, University Hospital LMU Munich  Munich Germany"},{"name":"Comprehensive Cancer Center Munich LMU (CCC Munich)  Munich Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0026-7779","authenticated-orcid":false,"given":"Friederike","family":"Mumm","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine III, University Hospital LMU Munich  Munich Germany"},{"name":"Comprehensive Cancer Center Munich LMU (CCC Munich)  Munich Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9534-6738","authenticated-orcid":false,"given":"Navdeep","family":"Dehar","sequence":"additional","affiliation":[{"name":"Department of Medical Oncology Queen's University  Kingston Ontario Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8014-5116","authenticated-orcid":false,"given":"Erin","family":"Dickman","sequence":"additional","affiliation":[{"name":"Oncology Nursing Society  Pittsburgh Pennsylvania USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2630-2106","authenticated-orcid":false,"given":"Celia","family":"D\u00edez\u00a0de\u00a0Los\u00a0R\u00edos\u00a0de\u00a0la\u00a0Serna","sequence":"additional","affiliation":[{"name":"European Oncology Nursing Society  Brussels Belgium"},{"name":"Faculty of Medicine and Health Sciences, School of Nursing Barcelona University  Barcelona Catalonia Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6587-1550","authenticated-orcid":false,"given":"Andreas","family":"Dinkel","sequence":"additional","affiliation":[{"name":"Department of Psychosomatic Medicine and Psychotherapy, Klinikum rechts der Isar, School of Medicine and Health Technical University of Munich  Munich Germany"},{"name":"Comprehensive Cancer Center Munich TUM (CCC Munich)  Munich Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3580-2313","authenticated-orcid":false,"given":"Kathrin","family":"Heinrich","sequence":"additional","affiliation":[{"name":"Comprehensive Cancer Center Munich LMU (CCC Munich)  Munich Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Merel","family":"Hennink","sequence":"additional","affiliation":[{"name":"Stichting Merels Wereld  Groningen The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5979-0826","authenticated-orcid":false,"given":"Anndra D.","family":"Parviainen","sequence":"additional","affiliation":[{"name":"Department of Nursing Science, Faculty of Health Sciences University of Eastern Finland  Kuopio Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vincent","family":"Raske","sequence":"additional","affiliation":[{"name":"The Synergist  Brussels Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2609-7376","authenticated-orcid":false,"given":"Nicole","family":"Wicki","sequence":"additional","affiliation":[{"name":"The Synergist  Brussels Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amy C.","family":"Moore","sequence":"additional","affiliation":[{"name":"LUNGevity Foundation  Chicago Illinois USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,1,31]]},"reference":[{"key":"e_1_2_10_2_1","unstructured":"Association of Community Cancer Centers.Lexicon.2022. 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