{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,23]],"date-time":"2026-01-23T16:10:18Z","timestamp":1769184618843,"version":"3.49.0"},"reference-count":32,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2024,2,13]],"date-time":"2024-02-13T00:00:00Z","timestamp":1707782400000},"content-version":"vor","delay-in-days":12,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100018724","name":"R\u00e9seau de canc\u00e9rologie Rossy","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100018724","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cancer Medicine"],"published-print":{"date-parts":[[2024,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Prostate cancer (PCa) patients receiving radiotherapy may be predisposed to secondary malignancies. This study aimed to determine the association between PCa treatments, including radical prostatectomy (RP), external beam radiation therapy (EBRT), brachytherapy (BT) and androgen deprivation therapy (ADT); and secondary bladder and colorectal cancer.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A cohort study was constructed using Quebec administrative databases (Med\u2010Echo and RAMQ). Included men were diagnosed and treated for PCa between 2000 and 2016. Patients with bladder or colorectal cancer prior to PCa were excluded. Follow\u2010up ended at the earliest of the following: incidence of bladder or colorectal cancer, death, or December 31, 2016. EBRT, BT, EBRT+ADT, RP\u2009+\u2009ADT or ADT only were compared individually to RP. The incidence of secondary bladder and colorectal cancer were computed. Inverse probability of treatment weighting (IPTW) based on a propensity score was used to control for potential confounding. IPTW\u2010Cox proportional hazards models were used.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A significant association was found between secondary bladder cancer and EBRT (HR: 1.84, 95%CI: 1.60;2.13), and also EBRT+ADT (HR: 2.08, 95%CI: 1.67;2.56), but not with BT (HR: 1.36, 95%CI: 0.68;2.74). Secondary colorectal cancer was significantly associated to either EBRT (HR: 1.36, 95%CI: 1.21;1.53); or BT (HR: 2.46, 95%CI: 1.71;3.54). The association between ADT alone and both secondary cancers was also significant (HR: 1.98, 95%CI: 1.69;2.31 and HR: 1.69, 95%CI: 1.49;1.92, respectively).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Compared to PCa patients undergoing RP, the secondary bladder cancer was associated with EBRT, ADT, alone or in combination. The secondary colorectal cancer was also associated with receiving either EBRT, BT or ADT.<\/jats:p><\/jats:sec>","DOI":"10.1002\/cam4.6922","type":"journal-article","created":{"date-parts":[[2024,2,14]],"date-time":"2024-02-14T07:04:40Z","timestamp":1707894280000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Secondary bladder and colorectal cancer after treatments for prostate cancer: A population based study"],"prefix":"10.1002","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7284-2766","authenticated-orcid":false,"given":"Patricia Grisel Quintana","family":"B\u00e1rcena","sequence":"first","affiliation":[{"name":"Urology, Department of Surgery McGill University  Montreal Quebec Canada"},{"name":"Research Institute of the McGill University Health Centre  Montreal Quebec Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Armen Garo","family":"Aprikian","sequence":"additional","affiliation":[{"name":"Urology, Department of Surgery McGill University  Montreal Quebec Canada"},{"name":"McGill University Health Centre  Montreal Quebec Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3858-3777","authenticated-orcid":false,"given":"Alice","family":"Dragomir","sequence":"additional","affiliation":[{"name":"Urology, Department of Surgery McGill University  Montreal Quebec Canada"},{"name":"Research Institute of the McGill University Health Centre  Montreal Quebec Canada"},{"name":"Faculty of pharmacy University of Montreal  Montreal Quebec Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2024,2,13]]},"reference":[{"key":"e_1_2_11_2_1","unstructured":"LeBlancAG DemersA ShawA.Recent trends in prostate cancer in Canada.2021https:\/\/www150.statcan.gc.ca\/n1\/pub\/82\u2010003\u2010x\/2019004\/article\/00002\u2010eng.htm"},{"key":"e_1_2_11_3_1","unstructured":"Canadian Cancer Society's Advisory Committee on Cancer Statistics.Canadian Cancer Statistics.2022."},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.eururo.2013.09.046"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijrobp.2008.04.004"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00520-017-3953-8"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijrobp.2009.02.090"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1464-410X.2012.11385.x"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/s1470-2045(13)70606-5"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/s1470-2045(11)70061-4"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.7150\/jca.44726"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.canep.2021.101967"},{"key":"e_1_2_11_13_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.i851"},{"key":"e_1_2_11_14_1","doi-asserted-by":"publisher","DOI":"10.1093\/jnci\/djq419"},{"key":"e_1_2_11_15_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10552-012-0132-6"},{"key":"e_1_2_11_16_1","doi-asserted-by":"publisher","DOI":"10.1093\/jnci\/95.13.981"},{"key":"e_1_2_11_17_1","doi-asserted-by":"publisher","DOI":"10.1097\/cco.0000000000000624"},{"key":"e_1_2_11_18_1","unstructured":"National Cancer Institute at the National Institutes of Health.NCI Dictionary of Cancer Terms.2023https:\/\/www.cancer.gov\/publications\/dictionaries\/cancer\u2010terms"},{"key":"e_1_2_11_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijrobp.2009.02.011"},{"key":"e_1_2_11_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.urology.2014.11.037"},{"key":"e_1_2_11_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijrobp.2009.09.055"},{"key":"e_1_2_11_22_1","doi-asserted-by":"publisher","DOI":"10.1080\/00273171.2011.568786"},{"key":"e_1_2_11_23_1","doi-asserted-by":"publisher","DOI":"10.1002\/sim.3854"},{"key":"e_1_2_11_24_1","doi-asserted-by":"publisher","DOI":"10.1002\/sim.5984"},{"key":"e_1_2_11_25_1","doi-asserted-by":"publisher","DOI":"10.1080\/03610910902859574"},{"key":"e_1_2_11_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijrobp.2014.07.032"},{"key":"e_1_2_11_27_1","doi-asserted-by":"publisher","DOI":"10.3857\/roj.2020.00857"},{"key":"e_1_2_11_28_1","doi-asserted-by":"publisher","DOI":"10.3389\/fonc.2021.784627"},{"key":"e_1_2_11_29_1","doi-asserted-by":"publisher","DOI":"10.3390\/diagnostics11020351"},{"key":"e_1_2_11_30_1","doi-asserted-by":"publisher","DOI":"10.18632\/oncotarget.3817"},{"key":"e_1_2_11_31_1","doi-asserted-by":"publisher","DOI":"10.1177\/107327481502200222"},{"key":"e_1_2_11_32_1","doi-asserted-by":"publisher","DOI":"10.1136\/gut.2005.073163"},{"key":"e_1_2_11_33_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.bjc.6601206"}],"container-title":["Cancer Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/cam4.6922","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,4,9]],"date-time":"2024-04-09T06:11:06Z","timestamp":1712643066000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/cam4.6922"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,2]]},"references-count":32,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2024,2]]}},"alternative-id":["10.1002\/cam4.6922"],"URL":"https:\/\/doi.org\/10.1002\/cam4.6922","archive":["Portico"],"relation":{},"ISSN":["2045-7634","2045-7634"],"issn-type":[{"value":"2045-7634","type":"print"},{"value":"2045-7634","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,2]]},"assertion":[{"value":"2023-05-05","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-12-28","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-02-13","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e6922"}}