{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,20]],"date-time":"2026-09-20T18:23:34Z","timestamp":1789928614828,"version":"4.0.1"},"reference-count":27,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2024,2,7]],"date-time":"2024-02-07T00:00:00Z","timestamp":1707264000000},"content-version":"vor","delay-in-days":6,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cancer Medicine"],"published-print":{"date-parts":[[2024,2]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Aim<\/jats:title>\n                    <jats:p>We investigated the pathologic complete response rates (pCR) and survival outcomes of early breast cancer patients who underwent neoadjuvant chemotherapy (NAC) over 14\u2009years at a French comprehensive cancer center and reported pCR and survival outcomes by tumor subtypes and size.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>From January 2005 to December 2018, 1150 patients receiving NAC were identified. Correlations between cT stage, breast tumor response, axillary lymph node response, pCR, surgery, and outcomes were assessed. pCR was defined as (ypT0\/ypTis) and (ypN0\/pN0sn).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>A pCR was reached in 31.7% (365\/1150) of patients and was strongly associated with tumor subtypes, but not with tumor size (pretreatment cT category). Luminal\u2010B Her2\u2010negative and triple\u2010negative (TN) subtypes, cN1 status, older age, and no\u2010pCR had an independent negative prognostic value. Overall survival (OS), relapse\u2010free survival (RFS), and metastasis\u2010free survival (MFS) were not significantly different for cT0\u20101 compared to cT2 stages. In Cox\u2010model adjusted on in\u2010breast pCR and pN status, ypN1 had a strong negative impact (OS, RFS, and MFS: HR\u2009=\u20093.153, 4.677, and 6.133, respectively), higher than no in\u2010breast pCR (HR\u2009=\u20092.369, 2.252, and 2.323). A negative impact of no pCR on OS was observed for cN0 patients and TN tumors (HR\u2009=\u20094.972) or HER2\u2010positive tumors (HR\u2009=\u200911.706), as well as in Luminal\u2010B Her2\u2010negative tumors on MFS (HR\u2009=\u20092.223) and for Luminal\u2010A on RFS (HR\u2009=\u20094.465) and MFS (HR\u2009=\u20094.185).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Achievement of pCR, but not tumor size (pretreatment cT category), has an independent prognostic impact on survival. These results suggest potential NAC benefits in patients with small tumors (&lt;2\u2009cm), even in absence of clinically suspicious lymph nodes. Residual lymph node disease after NAC is the most powerful adverse prognostic factor.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/cam4.6930","type":"journal-article","created":{"date-parts":[[2024,2,8]],"date-time":"2024-02-08T02:04:00Z","timestamp":1707357840000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":20,"title":["Neoadjuvant chemotherapy for breast cancer: Pathologic response rates but not tumor size, has an independent prognostic impact on survival"],"prefix":"10.1002","volume":"13","author":[{"given":"Gilles","family":"Houvenaeghel","sequence":"first","affiliation":[{"name":"Department of Surgical Oncology Aix\u2010Marseille University, CNRS, INSERM, Institute Paoli\u2010Calmettes, CRCM  Marseille France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6710-8284","authenticated-orcid":false,"given":"Alexandre","family":"de 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