{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,30]],"date-time":"2025-12-30T17:48:08Z","timestamp":1767116888666,"version":"3.41.2"},"reference-count":30,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2024,3,29]],"date-time":"2024-03-29T00:00:00Z","timestamp":1711670400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cancer Medicine"],"published-print":{"date-parts":[[2024,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>To examine standardized uptake value<jats:sub>max<\/jats:sub> of the primary lesion (pSUVmax) and tumor markers (TMs) for clinically predicting distant metastasis in novo lung adenocarcinoma.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>The current retrospective observational study examined individuals diagnosed with de novo lung adenocarcinoma at Shanxi Cancer Hospital between February 2015 and December 2019.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Totally, 532 de novo lung adenocarcinoma cases were included. They were aged 60.8\u2009\u00b1\u20099.7\u2009years and comprised 224 women and 268 patients with distant metastasis. The areas under the curves (AUCs) of pSUVmax, lactate dehydrogenase (LDH), carcinoembryonic antigen (CEA), cytokeratin\u201019 fragment (CYFRA21\u20101), carbohydrate antigen 125 (CA125), and Grade of TMs for predicting distant metastasis were 0.742, 0.601, 0.671, 0.700, 0.736, and 0.745, respectively. The combination of pSUVmax, LDH, CEA, CYFRA21\u20101, CA125, and grade of TMs in predicting distant metastasis had an AUC value of 0.816 (95%CI: 0.781\u20130.851), with sensitivity of 89.2%, specificity of 58.7%, positive predictive value of 73.7%, and negative predictive value of 79.7%, respectively.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>pSUVmax combined with serum levels of LDH, CEA, CYFRA21\u20101, CA125, and the grade of TMs may have good performance in predicting distant metastasis of de novo lung adenocarcinoma.<\/jats:p><\/jats:sec>","DOI":"10.1002\/cam4.6961","type":"journal-article","created":{"date-parts":[[2024,3,29]],"date-time":"2024-03-29T07:13:06Z","timestamp":1711696386000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Standardized uptake value<sub>max<\/sub> of the primary lesion combined with tumor markers for clinically predicting distant metastasis in de novo lung adenocarcinoma"],"prefix":"10.1002","volume":"13","author":[{"given":"Baoli","family":"Jin","sequence":"first","affiliation":[{"name":"Department of Radiation Oncology, Shanxi Province Cancer Hospital, Shanxi Hospital Affiliated to Cancer Hospital Chinese Academy of Medical Sciences, Cancer Hospital Affiliated to Shanxi Medical University  Taiyuan China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiaolian","family":"Wen","sequence":"additional","affiliation":[{"name":"Department of Oncology, Shanxi Province Cancer Hospital, Shanxi Hospital Affiliated to Cancer Hospital Chinese Academy of Medical Sciences, Cancer Hospital Affiliated to Shanxi Medical University  Taiyuan China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hanji","family":"Tian","sequence":"additional","affiliation":[{"name":"Department of Surgery, Shanxi Province Cancer Hospital, Shanxi Hospital Affiliated to Cancer Hospital Chinese Academy of Medical Sciences, Cancer 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