{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,31]],"date-time":"2025-10-31T14:33:43Z","timestamp":1761921223820,"version":"3.41.2"},"reference-count":33,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2024,2,1]],"date-time":"2024-02-01T00:00:00Z","timestamp":1706745600000},"content-version":"vor","delay-in-days":31,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100019018","name":"Chinese Academy of Medical Sciences Initiative for Innovative Medicine","doi-asserted-by":"publisher","award":["2022\u2010I2M\u20101\u2010022"],"award-info":[{"award-number":["2022\u2010I2M\u20101\u2010022"]}],"id":[{"id":"10.13039\/501100019018","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cancer Medicine"],"published-print":{"date-parts":[[2024,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>High\u2010dose chemotherapy followed by autologous stem cell transplantation (ASCT) remains an effective treatment for non\u2010Hodgkin lymphoma (NHL). The limited availability of carmustine has prompted the exploration of novel alternative conditioning regimens. This study aimed to compare the efficacy and safety profile of GBM\/GBC (gemcitabine, busulfan, and melphalan or cyclophosphamide) conditioning compared with the standard BEAM\/BEAC regimens (carmustine, etoposide, cytarabine, and melphalan or cyclophosphamide) for ASCT in patients with NHL.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A retrospective analysis was conducted on 231 NHL patients, who underwent ASCT from October 2010 to October 2021 at the Institute of Hematology &amp; Blood Disease Hospital, including both first\u2010line and salvage settings. This resulted in the inclusion of 112 patients in the GBM\/GBC arm and 92 in the BEAM\/BEAC arm. Propensity score matching was employed to validate the results.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Disease subtype distribution was similar between the GBM\/GBC and BEAM\/BEAC groups, with diffuse large B\u2010cell lymphoma being the most common (58.9% vs. 58.7%), followed by PTCL (17.0% vs. 18.5%) and MCL (14.3% vs. 14.1%). At 3\u2009months post\u2010ASCT, complete response (CR) rates were comparable (GBM\/GBC 93.5% vs. BEAM\/BEAC 91.1%; <jats:italic>p<\/jats:italic>\u2009=\u20090.607). The 4\u2010year progression\u2010free survival (78.4% vs. 82.3%; <jats:italic>p<\/jats:italic>\u2009=\u20090.455) and 4\u2010year overall survival (88.1% vs. 87.7%; <jats:italic>p<\/jats:italic>\u2009=\u20090.575) were also similar. Both groups exhibited low non\u2010relapse mortality at 4\u2009years (GBM\/GBC 1.8% vs. BEAM\/BEAC 3.5%; <jats:italic>p<\/jats:italic>\u2009=\u20090.790) with no transplant\u2010related mortalities reported. The GBM\/GBC cohort demonstrated a higher incidence of grade 3\/4 oral mucositis and hepatic toxicity, whereas the BEAM\/BEAC group had more frequent cases of bacteremia or sepsis (13 cases vs. 5 in GBM\/GBC).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>The GBM\/GBC regimen is effective and well\u2010tolerated, offering outcomes that are highly comparable to those in NHL patients conditioned with BEAM\/BEAC, as demonstrated in a prognostically matched cohort.<\/jats:p><\/jats:sec>","DOI":"10.1002\/cam4.6965","type":"journal-article","created":{"date-parts":[[2024,2,1]],"date-time":"2024-02-01T11:38:35Z","timestamp":1706787515000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Gemcitabine\u2010based conditioning compared to <scp>BEAM<\/scp>\/<scp>BEAC<\/scp> conditioning prior to autologous stem cell transplantation for <scp>non\u2010Hodgkin<\/scp> lymphoma: No difference in outcomes"],"prefix":"10.1002","volume":"13","author":[{"given":"Huimin","family":"Liu","sequence":"first","affiliation":[{"name":"State Key Laboratory of Experimental Hematology, National Clinical Research Center for Blood Diseases, Haihe Laboratory of Cell Ecosystem Institute of Hematology and Blood Diseases Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College  Tianjin China"},{"name":"Tianjin Institutes of Health Science  Tianjin China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hesong","family":"Zou","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Experimental Hematology, National Clinical Research Center for Blood Diseases, Haihe Laboratory of Cell Ecosystem Institute of Hematology and Blood Diseases Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College  Tianjin China"},{"name":"Tianjin Institutes of Health Science  Tianjin 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