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Volumetric compositional breast density (BD<jats:sub>sxa<\/jats:sub>) data were measured by single x\u2010ray absorptiometry techniques. Digital screening mammography was performed by the San Francisco Mammography Registry. Radiologists reviewed mammograms and assigned a Breast Imaging\u2010Reporting and Data System score. Early morning salivary Cd samples were assayed. Association analyses were then performed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Cd was quantifiable in over 90% of saliva samples (mean\u2009=\u200955.7\u2009pg\/L, SD\u2009=\u200929). Women with higher saliva Cd levels had a non\u2010significant odds ratio of 1.34 with BI\u2010RAD scores (3 or 4) (95% CI 0.75\u20132.39, <jats:italic>p<\/jats:italic>\u2009=\u20090.329). Cd levels were higher in current smokers (mean\u2009=\u200961.4\u2009pg\/L, SD\u2009=\u200934.8) than former smokers or non\u2010smokers. These results were non\u2010significant. Pilot data revealed that higher age and higher BMI were associated with higher BI\u2010RAD scores (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Salivary Cd is a viable quantification source in large epidemiologic studies. Association analyses between Cd levels and breast density may provide additional information for breast cancer risk assessment, risk reduction plans, and future research directions. Further work is needed to demonstrate a more robust testing protocol before the extent of its usefulness can be established.<\/jats:p><\/jats:sec>","DOI":"10.1002\/cam4.6973","type":"journal-article","created":{"date-parts":[[2024,2,1]],"date-time":"2024-02-01T11:54:21Z","timestamp":1706788461000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Assessment of salivary cadmium levels and breast density in the Marin Women's Study"],"prefix":"10.1002","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0863-6615","authenticated-orcid":false,"given":"Michaela F.","family":"George","sequence":"first","affiliation":[{"name":"Global Public Health Department, School of Health and Natural Sciences Dominican University of California  San Rafael California 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