{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,25]],"date-time":"2026-07-25T04:04:31Z","timestamp":1784952271193,"version":"3.55.0"},"reference-count":19,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2024,2,24]],"date-time":"2024-02-24T00:00:00Z","timestamp":1708732800000},"content-version":"vor","delay-in-days":23,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cancer Medicine"],"published-print":{"date-parts":[[2024,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Introduction<\/jats:title><jats:p>Stereotactic body radiation therapy (SBRT) is associated with high local control rates in hepatocellular carcinoma (HCC). This study reports the outcomes of SBRT compared to surgical resection (SR) and percutaneous ablation (PA) for treatment\u2010na\u00efve, solitary HCCs \u22643\u2009cm.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This was a retrospective study of patients with BCLC stage 0\/A HCC with a single \u22643\u2009cm lesion, treated with curative intent between 2016 and 2020. SBRT was used for patients considered unsuitable for SR or PA. The co\u2010primary endpoints were progression\u2010free survival (PFS) and overall survival (OS). The secondary endpoints were treatment\u2010related clinical toxicity rates and local control (LC) rates.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>There were 112 patients included in this study. SBRT was delivered in 36 patients (32.1%), 51 had PA (45.5%) and 25 underwent SR (22.3%). Median follow\u2010up was 23\u2009months (range, 3\u201360\u2009months) from diagnosis. The 3\u2010year PFS and OS were 67% and 69% following SBRT, 55% and 80% following PA, and 85% and 100% following SR, respectively. Patients in the SR cohort had significantly better 3\u2010year PFS and OS compared to SBRT and PA groups (<jats:italic>p<\/jats:italic>\u2009=\u20090.03 and <jats:italic>p<\/jats:italic>\u2009=\u20090.04, respectively). There was no significant difference in PFS (<jats:italic>p<\/jats:italic>\u2009=\u20090.15) or OS (<jats:italic>p<\/jats:italic>\u2009=\u20090.23) between SBRT and PA treated patients. The 3\u2010year LC rate for the entire cohort was 98%.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>In patients with treatment\u2010na\u00efve, early\u2010stage solitary HCCs \u22643\u2009cm, SBRT was associated with comparable PFS, OS and LC outcomes to PA. SBRT should be considered as a curative intent therapy to avoid treatment stage migration in this favourable prognostic cohort of patients.<\/jats:p><\/jats:sec>","DOI":"10.1002\/cam4.6978","type":"journal-article","created":{"date-parts":[[2024,2,24]],"date-time":"2024-02-24T09:29:52Z","timestamp":1708766992000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Comparison of outcomes following surgical resection, percutaneous ablation or stereotactic body radiation therapy in early\u2010stage, solitary and small (\u22643\u2009cm) treatment\u2010na\u00efve hepatocellular carcinoma"],"prefix":"10.1002","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7599-7613","authenticated-orcid":false,"given":"A. M.","family":"Maher","sequence":"first","affiliation":[{"name":"Gastroenterology and Hepatology Princess Alexandra Hospital  Brisbane Queensland Australia"},{"name":"Faculty of Medicine The University of Queensland  Herston Queensland Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Shanker","sequence":"additional","affiliation":[{"name":"Faculty of Medicine The University of Queensland  Herston Queensland Australia"},{"name":"Radiation Oncology Princess Alexandra Hospital  Brisbane Queensland Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H. Y. H.","family":"Liu","sequence":"additional","affiliation":[{"name":"Faculty of Medicine The University of Queensland  Herston Queensland Australia"},{"name":"Radiation Oncology Princess Alexandra Hospital  Brisbane Queensland Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Y.","family":"Lee","sequence":"additional","affiliation":[{"name":"Faculty of Medicine The University of Queensland  Herston Queensland Australia"},{"name":"Radiation Oncology Princess Alexandra Hospital  Brisbane Queensland Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D.","family":"Leggett","sequence":"additional","affiliation":[{"name":"Faculty of Medicine The University of Queensland  Herston Queensland Australia"},{"name":"Department of Medical Imaging Princess Alexandra Hospital  Brisbane Queensland Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P.","family":"Hodgkinson","sequence":"additional","affiliation":[{"name":"Faculty of Medicine The University of Queensland  Herston Queensland Australia"},{"name":"Department of Hepatobiliary and Pancreatic Surgery Princess Alexandra Hospital  Brisbane Queensland Australia"},{"name":"Queensland Liver Transplant Service  Brisbane Queensland Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D.","family":"Pryor","sequence":"additional","affiliation":[{"name":"Faculty of Medicine The University of Queensland  Herston Queensland Australia"},{"name":"Radiation Oncology Princess Alexandra Hospital  Brisbane Queensland Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K. A.","family":"Stuart","sequence":"additional","affiliation":[{"name":"Gastroenterology and Hepatology Princess Alexandra Hospital  Brisbane Queensland Australia"},{"name":"Queensland Liver Transplant Service  Brisbane Queensland Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,2,24]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.3322\/caac.21660"},{"key":"e_1_2_10_3_1","unstructured":"Health AIo Welfare.Cancer in Australia 2019.https:\/\/www.aihw.gov.au\/reports\/cancer\/cancer\u2010in\u2010australia\u201020192019."},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.5694\/mja2.50885"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2018.03.019"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1080\/00365521.2018.1517277"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrclinonc.2014.237"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2021.11.018"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1080\/0284186X.2019.1657942"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/1754-9485.13184"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.29086"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clon.2020.04.004"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.2147\/JHC.S284403"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1002\/jgh3.12793"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1097\/HEP.0000000000000466"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.prro.2021.09.004"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.1111\/hepr.13595"},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijrobp.2019.12.004"},{"key":"e_1_2_10_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0167-8140(23)09021-7"},{"key":"e_1_2_10_20_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep4.2089"}],"container-title":["Cancer Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/cam4.6978","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,4,9]],"date-time":"2024-04-09T06:07:13Z","timestamp":1712642833000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/cam4.6978"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,2]]},"references-count":19,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2024,2]]}},"alternative-id":["10.1002\/cam4.6978"],"URL":"https:\/\/doi.org\/10.1002\/cam4.6978","archive":["Portico"],"relation":{},"ISSN":["2045-7634","2045-7634"],"issn-type":[{"value":"2045-7634","type":"print"},{"value":"2045-7634","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,2]]},"assertion":[{"value":"2023-09-13","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-01-18","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-02-24","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e6978"}}