{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,24]],"date-time":"2026-07-24T01:39:48Z","timestamp":1784857188524,"version":"3.55.0"},"reference-count":37,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2024,3,16]],"date-time":"2024-03-16T00:00:00Z","timestamp":1710547200000},"content-version":"vor","delay-in-days":15,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cancer Medicine"],"published-print":{"date-parts":[[2024,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Purpose<\/jats:title><jats:p>Resistance training may offer several unique advantages within breast cancer (BC) survivorship care; however, safety concerns have limited the application of high\u2010intensity compound movements necessary to elicit optimal changes in body composition, strength, and quality of life in this population. The EXERT\u2010BC trial assesses the safety and feasibility of an evidence\u2010based, dose\u2010escalated resistance training regimen among BC survivors, with the goal of improving physical and metabolic function, mobility, muscle mass, and body composition.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Participants included women with breast cancer underwent a 3\u2010month thrice weekly exercise regimen involving dose escalation of high\u2010intensity compound exercises. Coprimary outcomes included safety and adherence. Pre\u2010 and post\u2010regimen assessment included body composition testing, functional mobility and balance, total load (weight\u2009\u00d7\u2009repetitions\u2009\u00d7\u2009sets) across compound exercises, and patient reported quality of life. Pairwise comparison was performed via the paired <jats:italic>t<\/jats:italic> test.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Fourty participants completed a 3\u2010month exercise regimen, with a median age of 57\u2009years (range, 27\u201374\u2009years) and 73% having stage 0\u20132\u2009BC. BC therapies concurrent with exercise included anti\u2010estrogen therapy (80%), radiotherapy (30%), and non\u2010hormonal systemic therapy (15%). No adverse events were observed aside from a single case of self\u2010limited knee pain. Session attendance exceeded a prespecified threshold of 75%, and 98% patients reported ongoing compliance to an exercise regimen following regimen completion.<\/jats:p><jats:p>Significant reductions in percent body fat (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001) and increases in percent muscle mass (<jats:italic>p<\/jats:italic>\u2009=\u20090.011) were observed. Significant increases in resting metabolic rate (<jats:italic>p<\/jats:italic>\u2009=\u20090.023), bilateral grip strength (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001), functional movement screen (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001), bilateral Y\u2010Balance testing (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001), and Godin questionnaire scores (p\u2009&lt;\u20090.001) were observed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>A 3\u2010month dose\u2010escalated resistance training regimen comprising high\u2010intensity compound movements appears safe with a high degree of adherence among breast cancer survivors, resulting in demonstrable improvements in body composition, metabolic parameters, strength increases, and patient\u2010reported quality of life.<\/jats:p><\/jats:sec>","DOI":"10.1002\/cam4.7001","type":"journal-article","created":{"date-parts":[[2024,3,16]],"date-time":"2024-03-16T08:04:48Z","timestamp":1710576288000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":14,"title":["EXERT\u2010BC: A pilot study of an exercise regimen designed to improve functional mobility, body composition, and strength after the treatment for breast cancer"],"prefix":"10.1002","volume":"13","author":[{"given":"David J.","family":"Carpenter","sequence":"first","affiliation":[{"name":"Department of Radiation Oncology Wellstar Paulding Medical Center  Hiram Georgia USA"},{"name":"Department of Radiation Oncology Duke University Medical Center  Durham North Carolina USA"},{"name":"Exercise Oncology Consortium  Pittsburgh Pennsylvania USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chris","family":"Peluso","sequence":"additional","affiliation":[{"name":"Exercise 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