{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T04:05:20Z","timestamp":1792123520356,"version":"4.4.0"},"reference-count":30,"publisher":"Wiley","issue":"14","license":[{"start":{"date-parts":[[2024,7,23]],"date-time":"2024-07-23T00:00:00Z","timestamp":1721692800000},"content-version":"vor","delay-in-days":22,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100004731","name":"Natural Science Foundation of Zhejiang Province","doi-asserted-by":"publisher","award":["LY22H080004"],"award-info":[{"award-number":["LY22H080004"]}],"id":[{"id":"10.13039\/501100004731","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cancer Medicine"],"published-print":{"date-parts":[[2024,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>There are limited studies on mutation profiling for Peripheral T\u2010cell lymphomas (PTCL) in the Chinese population. We retrospectively analyzed the clinical and genetic landscape of 66 newly diagnosed Chinese patients. Targeted next\u2010generation sequencing (NGS) was performed for tissues from these patients. At least one mutation was detected in 60 (90.9%) patients, with a median number of 3 (0\u20137) mutations, and 32 (48.5%) cases detected with more than 4 mutations. The genes with higher mutation frequencies were TET2, RHOA, DNMT3A, IDH2, TP53, STAT3, and KMT2D respectively. When mutant genes are classified by functional group, the most prevalent mutations are related to epigenetics and signal transduction. IPI \u22652, PIT \u22652, and failure to achieve partial remission (PR) were factors for inferior progression\u2010free survival (PFS) and overall survival (OS). Multivariate analysis showed TP53 was an adverse factor for PFS (HR, 3.523; 95% CI, 1.262\u20139.835; <jats:italic>p<\/jats:italic>\u2009=\u20090.016), and KMT2D was an adverse factor for OS (HR, 10.097; 95% CI, 1.000\u2013101.953; <jats:italic>p<\/jats:italic>\u2009=\u20090.048). Mutation profiling could help differentiate distinct types of PTCL and serve as a useful tool for determining treatment options and prognoses.<\/jats:p>","DOI":"10.1002\/cam4.70027","type":"journal-article","created":{"date-parts":[[2024,7,23]],"date-time":"2024-07-23T15:18:42Z","timestamp":1721747922000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["TP53 and KMT2D mutations associated with worse prognosis in peripheral T\u2010cell lymphomas"],"prefix":"10.1002","volume":"13","author":[{"given":"Lingling","family":"Wang","sequence":"first","affiliation":[{"name":"Bone Marrow Transplantation Center The First Affiliated Hospital, School of Medicine, Zhejiang University  Hangzhou China"},{"name":"Department of Hematology The First People's Hospital of Yancheng, The Yancheng Clinical College of Xuzhou Medical University  Yancheng 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