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Although other cancer predisposition syndromes have established cancer screening protocols, evidence\u2010based guidelines for cancer screening in A\u2010T are lacking. This study sought to assess feasibility of a cancer screening protocol based on whole\u2010body MRI (WB\u2010MRI) in children and young people with A\u2010T.<\/jats:p><\/jats:sec><jats:sec><jats:title>Design\/Methods<\/jats:title><jats:p>Children and young people with A\u2010T were invited to undergo a one\u2010off non\u2010sedated 3\u2010Tesla WB\u2010MRI. Completion rate of WB\u2010MRI was recorded and diagnostic image quality assessed by two experienced radiologists, with pre\u2010specified success thresholds for scan completion of &gt;50% participants and image quality between acceptable to excellent in 65% participants. Positive imaging findings were classified according to the ONCO\u2010RADS system. Post\u2010participation interviews were performed with recruited families to assess the experience of participating and feelings about waiting for, and communication of, the findings of the scan.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Forty\u2010six children and young people with A\u2010T were identified, of which 36 were eligible to participate, 18 were recruited and 16 underwent WB\u2010MRI. Nineteen parents participated in interviews. Fifteen participants (83%) completed the full WB\u2010MRI scan protocol. The pre\u2010specified image quality criterion was achieved with diagnostic images obtained in at least 93% of each MRI sequence. Non\u2010malignant scan findings were present in 4 (25%) participants. Six themes were identified from the interviews: (1) anxiety is a familiar feeling, (2) the process of MRI scanning is challenging for some children and families, (3) preparation is essential to reduce stress, (4) WB\u2010MRI provides the reassurance about the physical health that families need, (5) WB\u2010MRI experience turned out to be a positive experience and (6) WB\u2010MRI allows families to be proactive.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>This study shows that WB\u2010MRI for cancer screening is feasible and well\u2010accepted by children and young people with A\u2010T and their families.<\/jats:p><\/jats:sec>","DOI":"10.1002\/cam4.70049","type":"journal-article","created":{"date-parts":[[2024,7,26]],"date-time":"2024-07-26T12:09:20Z","timestamp":1721995760000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Feasibility of whole\u2010body <scp>MRI<\/scp> for cancer screening in children and young people with ataxia telangiectasia: A mixed methods cross\u2010sectional study"],"prefix":"10.1002","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8835-2366","authenticated-orcid":false,"given":"Renata","family":"Neves","sequence":"first","affiliation":[{"name":"Radiological Sciences, Mental Health and Clinical Neuroscience, School of Medicine University of Nottingham  Nottingham UK"},{"name":"Department of Radiology Nottingham University Hospitals NHS Trust  Nottingham UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rafal","family":"Panek","sequence":"additional","affiliation":[{"name":"Medical Physics and Clinical Engineering Nottingham University Hospitals NHS Trust  Nottingham UK"},{"name":"School of Medicine University of Nottingham  Nottingham UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katie","family":"Clarkson","sequence":"additional","affiliation":[{"name":"Radiological Sciences, 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