{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,3]],"date-time":"2026-02-03T18:47:51Z","timestamp":1770144471356,"version":"3.49.0"},"reference-count":38,"publisher":"Wiley","issue":"15","license":[{"start":{"date-parts":[[2024,7,31]],"date-time":"2024-07-31T00:00:00Z","timestamp":1722384000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cancer Medicine"],"published-print":{"date-parts":[[2024,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>There was limited research data on large\u2010scale locally advanced non\u2010small cell lung cancer (LA\u2010NSCLC) radical radiotherapy (RT) reported in China. This study examined overall survival (OS), progression\u2010free survival (PFS), treatment effectiveness, and toxicity in patients with LA\u2010NSCLC treated with definitive RT in the pre\u2010durvalumab era.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A retrospective analysis of demographic information, clinical characteristics, treatment patterns, and clinical outcomes of 789 patients with LA\u2010NSCLC who underwent radical RT at our center between January 2005 and December 2015 was performed. The Kaplan\u2013Meier method and log\u2010rank test were used for survival comparisons, and Cox regression was used for multivariate analysis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>There were 328 patients with stage IIIA disease and 461 with stage IIIB disease. By the last follow\u2010up, there were 365 overall deaths and 576 cases of recurrence, metastasis, or death. The median survival time was 31\u2009months. The OS rates at 1, 2, 5, and 10\u2009years were 83.7%, 59.5%, 28.8%, and 18.9%, respectively. PFS rates at 1, 2, 5, and 10\u2009years were 48%, 24.5%, 11.9%, and 5.5%, respectively. Rates of \u2265grade 3 acute radiation pneumonitis or esophagitis were 7.6% and 1.9%, respectively. Rates of \u2265grade 3 chronic radiation pneumonitis and esophagitis were 11% and 0.4%, respectively. Multivariate analysis showed that the Karnofsky Performance Status (KPS) score, smoking status, and combined chemotherapy were prognostic factors for OS (<jats:italic>p\u2009&lt;<\/jats:italic>\u20090.05). Multivariate analysis revealed that combined chemotherapy and radiation dose were prognostic factors for PFS (<jats:italic>p\u2009&lt;<\/jats:italic>\u20090.05).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Our center's data showed that the survival prognosis of locally advanced patients receiving RT and chemotherapy in China was consistent with international levels during the same period. Patients with a KPS score of 80 or higher, who had never smoked or received combined RT, had a more favorable prognosis than those with a KPS of less than 80, who had smoked, or only received RT. The combination of RT and chemotherapy, with a reasonable radiation dose, was the key to improving the therapeutic effect.<\/jats:p><\/jats:sec>","DOI":"10.1002\/cam4.70051","type":"journal-article","created":{"date-parts":[[2024,7,31]],"date-time":"2024-07-31T15:32:59Z","timestamp":1722439979000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Long\u2010term outcome of definitive radiotherapy for locally advanced non\u2010small cell lung cancer: A real\u2010world single\u2010center study in the pre\u2010durvalumab era"],"prefix":"10.1002","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0682-3297","authenticated-orcid":false,"given":"Hong","family":"Zhu","sequence":"first","affiliation":[{"name":"Department of Radiation Oncology Fudan University Shanghai Cancer Center  Shanghai China"},{"name":"Department of Radiation Oncology, Tongji Hospital Tongji University School of Medicine  Shanghai China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yi","family":"Xu","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology Fudan University Shanghai Cancer Center  Shanghai China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Huiquan","family":"Gao","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology Fudan University Shanghai Cancer Center  Shanghai China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6085-8434","authenticated-orcid":false,"given":"Xingwen","family":"Fan","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology Fudan University Shanghai Cancer Center  Shanghai China"},{"name":"Department of Oncology Shanghai Medical College, Fudan University  Shanghai China"},{"name":"Shanghai Clinical Research Center for Radiation Oncology  Shanghai China"},{"name":"Shanghai Key Laboratory of Radiation Oncology  Shanghai China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ming","family":"Fan","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology Fudan University Shanghai Cancer Center  Shanghai China"},{"name":"Department of Oncology Shanghai Medical College, Fudan University  Shanghai China"},{"name":"Shanghai Clinical Research Center for Radiation Oncology  Shanghai China"},{"name":"Shanghai Key Laboratory of Radiation Oncology  Shanghai China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8663-2874","authenticated-orcid":false,"given":"Kuaile","family":"Zhao","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology Fudan University Shanghai Cancer Center  Shanghai China"},{"name":"Department of Oncology Shanghai Medical College, Fudan University  Shanghai China"},{"name":"Shanghai Clinical Research Center for Radiation Oncology  Shanghai China"},{"name":"Shanghai Key Laboratory of Radiation Oncology  Shanghai China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Huanjun","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology Fudan University Shanghai Cancer Center  Shanghai China"},{"name":"Department of Oncology Shanghai Medical College, Fudan University  Shanghai China"},{"name":"Shanghai Clinical Research Center for Radiation Oncology  Shanghai China"},{"name":"Shanghai Key Laboratory of Radiation Oncology  Shanghai China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7537-3619","authenticated-orcid":false,"given":"Zhengfei","family":"Zhu","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology Fudan University Shanghai Cancer Center  Shanghai China"},{"name":"Department of Oncology Shanghai Medical College, Fudan University  Shanghai China"},{"name":"Shanghai Clinical Research Center for Radiation Oncology  Shanghai China"},{"name":"Shanghai Key Laboratory of Radiation Oncology  Shanghai China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kailiang","family":"Wu","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology Fudan University Shanghai Cancer Center  Shanghai China"},{"name":"Department of Oncology Shanghai Medical College, Fudan University  Shanghai China"},{"name":"Shanghai Clinical Research Center for Radiation Oncology  Shanghai China"},{"name":"Shanghai Key Laboratory of Radiation Oncology  Shanghai China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2024,7,31]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.3322\/caac.21492"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.3322\/caac.21349"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1097\/JTO.0b013e3181c5920c"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1093\/jnci\/djr325"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2009.26.2543"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13014-016-0693-8"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2014.59.2360"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.5306\/wjco.v8.i1.1"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.19.01162"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1470-2045(14)71207-0"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.1093\/annonc\/mdv187"},{"key":"e_1_2_11_13_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1809697"},{"key":"e_1_2_11_14_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.21.01308"},{"key":"e_1_2_11_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jtho.2021.05.003"},{"key":"e_1_2_11_16_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12094-020-02521-5"},{"key":"e_1_2_11_17_1","doi-asserted-by":"publisher","DOI":"10.1093\/jnci\/djw034"},{"key":"e_1_2_11_18_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2014.56.2587"},{"key":"e_1_2_11_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1053-4296(03)00031-6"},{"issue":"83","key":"e_1_2_11_20_1","article-title":"Data\u2010based radiation oncology: design of clinical trials in the toxicity biomarkers era","volume":"7","author":"Azria D","year":"2017","journal-title":"Front Oncol"},{"key":"e_1_2_11_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.lungcan.2020.05.033"},{"key":"e_1_2_11_22_1","doi-asserted-by":"publisher","DOI":"10.1093\/annonc\/mdx009"},{"key":"e_1_2_11_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cllc.2013.12.007"},{"key":"e_1_2_11_24_1","doi-asserted-by":"publisher","DOI":"10.1097\/JTO.0b013e3181dc213e"},{"key":"e_1_2_11_25_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijerph6030874"},{"key":"e_1_2_11_26_1","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.201701-0218PP"},{"key":"e_1_2_11_27_1","doi-asserted-by":"publisher","DOI":"10.1177\/1533033820951802"},{"key":"e_1_2_11_28_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12885-020-06780-x"},{"key":"e_1_2_11_29_1","doi-asserted-by":"publisher","DOI":"10.1097\/MD.0000000000016167"},{"key":"e_1_2_11_30_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jtho.2017.11.135"},{"key":"e_1_2_11_31_1","doi-asserted-by":"publisher","DOI":"10.1378\/chest.12-2360"},{"key":"e_1_2_11_32_1","doi-asserted-by":"publisher","DOI":"10.5152\/balkanmedj.2014.14573"},{"key":"e_1_2_11_33_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.radonc.2016.07.025"},{"key":"e_1_2_11_34_1","doi-asserted-by":"publisher","DOI":"10.1093\/annonc\/mdw276"},{"issue":"4","key":"e_1_2_11_35_1","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0151988","article-title":"Is IMRT superior or inferior to 3D\u2010CRT in radiotherapy for NSCLC? A meta\u2010analysis","volume":"11","author":"Minna JD","year":"2016","journal-title":"PLoS One"},{"key":"e_1_2_11_36_1","doi-asserted-by":"publisher","DOI":"10.21037\/jtd.2018.07.29"},{"key":"e_1_2_11_37_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2016.69.1378"},{"key":"e_1_2_11_38_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijrobp.2013.07.029"},{"key":"e_1_2_11_39_1","doi-asserted-by":"publisher","DOI":"10.1186\/1748-717X-9-172"}],"container-title":["Cancer Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/cam4.70051","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,2]],"date-time":"2025-04-02T15:25:48Z","timestamp":1743607548000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/cam4.70051"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,7,31]]},"references-count":38,"journal-issue":{"issue":"15","published-print":{"date-parts":[[2024,8]]}},"alternative-id":["10.1002\/cam4.70051"],"URL":"https:\/\/doi.org\/10.1002\/cam4.70051","archive":["Portico"],"relation":{},"ISSN":["2045-7634","2045-7634"],"issn-type":[{"value":"2045-7634","type":"print"},{"value":"2045-7634","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,7,31]]},"assertion":[{"value":"2023-06-10","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-07-13","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-07-31","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e70051"}}