{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T13:32:23Z","timestamp":1792157543177,"version":"4.4.0"},"reference-count":55,"publisher":"Wiley","issue":"15","license":[{"start":{"date-parts":[[2024,7,31]],"date-time":"2024-07-31T00:00:00Z","timestamp":1722384000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cancer Medicine"],"published-print":{"date-parts":[[2024,8]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Cancer burden from the elderly has been rising largely due to the aging population. However, research on the long\u2010term epidemiological trends in cancer of the elderly is lacking.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Registry data of this population\u2010based cross\u2010sectional study were from the Surveillance, Epidemiology, and End Results (SEER) database. The study population aged 65\u2009years or more, from geographically distinct regions. Joinpoint regression and JP Surv method were used to analyze cancer trends and survival.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Mortality rate during 1975\u20132020 decreased from 995.20 to 824.99 per 100,000 elderly persons, with an average annual decrease of 0.421% (95% CI, 0.378\u20130.464). While overall incidence increased with no significance. Prostate (29%) and breast (26%) cancer were the most common malignancies, respectively, in elderly males and females, and the mortality for both of the two (prostate 15%, breast 14%) ranked just behind lung and bronchus cancer, which had the highest mortality rates in males (29%) and females (23%). Many cancers showed adverse trends in the latest follow\u2010up periods (the last period calculated by the Joinpoint method). For intrahepatic cholangiocarcinoma, incidence (male Annual Percentage Change [APC]\u2009=\u20097.4*; female APC\u2009=\u20096.7*) and mortality (male APC\u2009=\u20093.0*; female APC\u2009=\u20093.3*) increased relatively fast, and its survival was also terrible (3\u2010year survival only 10%). Other cancers with recent increasing mortality included cancer of anus, anal canal and anorectum, retroperitoneum, pleura, peritoneum, etc. Most cancers had favorable trends of survival during the nearest follow\u2010up period.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Against the background of overall improvement, many cancers showed adverse trends. Further research for the underlying mechanisms and targeted implements towards adverse trends is also urgent.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/cam4.70062","type":"journal-article","created":{"date-parts":[[2024,7,31]],"date-time":"2024-07-31T11:35:47Z","timestamp":1722425747000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["Trends analysis of cancer incidence, mortality, and survival for the elderly in the United States, 1975\u20132020"],"prefix":"10.1002","volume":"13","author":[{"given":"Jia","family":"Xu","sequence":"first","affiliation":[{"name":"Department of Gastroenterology The Affiliated Hospital of Southwest Medical University  Luzhou China"},{"name":"Nuclear Medicine and Molecular Imaging Key Laboratory of Sichuan Province  Luzhou 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