{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,24]],"date-time":"2026-06-24T21:24:49Z","timestamp":1782336289176,"version":"3.54.5"},"reference-count":38,"publisher":"Wiley","issue":"17","license":[{"start":{"date-parts":[[2024,9,9]],"date-time":"2024-09-09T00:00:00Z","timestamp":1725840000000},"content-version":"vor","delay-in-days":8,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cancer Medicine"],"published-print":{"date-parts":[[2024,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>Previous results about prognostic value of CD4+ T cells in follicular lymphoma (FL) remain controversial.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Immunohistochemistry was used to examine expression of positive CD4 cells in 103 patients with FL 1\u20103A. Early failure was described as failing to achieve event\u2010free survival (EFS) at 12 or 24\u2009months.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>There were 49 (47.6%) male and 54 (52.4%) females, with a median age of 54\u2009years. Compared to patients with &lt;20% of positive CD4 cells, patients with \u226520% of positive CD4 cells exhibited a significant lower risk of early failure (2\u2010year EFS rate: 56.7% vs 73.5%, <jats:italic>p<\/jats:italic>\u2009=\u20090.047). When patients were stratified based on positive CD4 cell combined with FLIPI, the median EFS (<jats:italic>p<\/jats:italic>\u2009=\u20090.002) and median OS (<jats:italic>p<\/jats:italic>\u2009=\u20090.007) were significantly different.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>This study demonstrated that higher expression of positive CD4 cells predicts lower risk of early failure in follicular lymphoma, and combination analysis of CD4 and FLIPI could better predict disease relapse and survival outcome.<\/jats:p><\/jats:sec>","DOI":"10.1002\/cam4.70117","type":"journal-article","created":{"date-parts":[[2024,9,9]],"date-time":"2024-09-09T10:13:33Z","timestamp":1725876813000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Impact of positive <scp>CD4<\/scp> cells on event\u2010free survival in follicular lymphoma patients"],"prefix":"10.1002","volume":"13","author":[{"given":"Cong","family":"Li","sequence":"first","affiliation":[{"name":"Department of Lymphoma, Zhejiang Cancer Hospital Hangzhou Institute of Medicine (HIM), Chinese Academy of Sciences  Hangzhou Zhejiang China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Na","family":"Guo","sequence":"additional","affiliation":[{"name":"Department of Pathology, Zhejiang Cancer Hospital Hangzhou Institute of Medicine (HIM), Chinese Academy of Sciences  Hangzhou Zhejiang China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shuiyun","family":"Han","sequence":"additional","affiliation":[{"name":"Department of Lymphoma, Zhejiang Cancer Hospital Hangzhou Institute of Medicine (HIM), Chinese Academy of Sciences  Hangzhou Zhejiang China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haifeng","family":"Yu","sequence":"additional","affiliation":[{"name":"Department of Lymphoma, Zhejiang Cancer 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