{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,12]],"date-time":"2026-10-12T20:50:29Z","timestamp":1791838229657,"version":"4.3.4"},"reference-count":50,"publisher":"Wiley","issue":"17","license":[{"start":{"date-parts":[[2024,9,13]],"date-time":"2024-09-13T00:00:00Z","timestamp":1726185600000},"content-version":"vor","delay-in-days":12,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cancer Medicine"],"published-print":{"date-parts":[[2024,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>To evaluate the outcomes of first\u2010line imatinib versus nilotinib treatment for chronic myeloid leukemia in the chronic phase (CML\u2010CP) in real\u2010world clinical practice.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A propensity score analysis was performed to eliminate imbalances between the treatment groups. In the analysis, 163 patients in the nilotinib group and 163 patients in the matched imatinib group were retrospectively evaluated.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Nilotinib\u2010treated patients achieved complete cytogenetic response (CCyR) and major molecular response more rapidly than imatinib\u2010treated patients. However, there was no significant difference in 5\u2010year overall survival (OS) or progression\u2010free survival (PFS) between the two groups (OS: 94.3% vs. 90.5%, <jats:italic>p<\/jats:italic>\u2009=\u20090.602; PFS: 92.9% vs. 88.0%, <jats:italic>p<\/jats:italic>\u2009=\u20090.614). Nilotinib\u2010treated patients had a higher failure\u2010free survival (FFS) and event\u2010free survival (EFS) than imatinib\u2010treated patients (FFS: 71.7% vs. 54.3%, <jats:italic>p<\/jats:italic>\u2009=\u20090.040; EFS: 71.7% vs. 53.5%, <jats:italic>p<\/jats:italic>\u2009=\u20090.025).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>This retrospective analysis from clinical practice did not confirm any benefit of frontline nilotinib treatment for OS and PFS; however, it did demonstrate higher FFS and EFS in the nilotinib cohort.<\/jats:p><\/jats:sec>","DOI":"10.1002\/cam4.70158","type":"journal-article","created":{"date-parts":[[2024,9,13]],"date-time":"2024-09-13T07:41:29Z","timestamp":1726213289000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Clinical efficacy and safety of first\u2010line nilotinib or imatinib therapy in patients with chronic myeloid leukemia\u2014Nationwide real life data"],"prefix":"10.1002","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8728-7443","authenticated-orcid":false,"given":"Petra","family":"Belohlavkova","sequence":"first","affiliation":[{"name":"4th Department of Internal Medicine and Haematology University Hospital Hradec Kralove and Charles University  Prague Czech Republic"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9802-8148","authenticated-orcid":false,"given":"Daniela","family":"Zackova","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine\u2013Haematology and Oncology University Hospital Brno and Masaryk University  Brno Czech Republic"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hana","family":"Klamova","sequence":"additional","affiliation":[{"name":"Institute of Haematology and Blood Transfusion  Prague Czech 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