{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T15:03:03Z","timestamp":1790694183462,"version":"4.1.0"},"reference-count":38,"publisher":"Wiley","issue":"16","license":[{"start":{"date-parts":[[2024,9,1]],"date-time":"2024-09-01T00:00:00Z","timestamp":1725148800000},"content-version":"vor","delay-in-days":31,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2024,8,1]],"date-time":"2024-08-01T00:00:00Z","timestamp":1722470400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82000599"],"award-info":[{"award-number":["82000599"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82170543"],"award-info":[{"award-number":["82170543"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cancer Medicine"],"published-print":{"date-parts":[[2024,8]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Although nucleos(t)ide analogues (NAs) are thought to reduce the risk of hepatitis B virus (HBV)\u2010related hepatocellular carcinoma (HCC), the effect of NA discontinuation on the prognosis of HBV\u2010related HCC after hepatectomy is rarely reported. We aimed to investigate the potential for hepatitis B virus e antigen (HBeAg)\u2010negative HBV\u2010related HCC patients to discontinue NAs based on preoperative hepatitis B virus surface antigen (HBsAg) status.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This historical cohort study involved 1232 NA\u2010treated HBeAg\u2010negative patients who underwent curative hepatectomy for HBV\u2010related HCC from 2014 to 2019. The recurrence\u2010free survival (RFS) and overall survival (OS) of patients discontinuing NAs before surgery were compared with those continuing NAs. Propensity score matching (PSM) was used to balance baseline characteristics.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Of all enrolled patients, 839 (68.1%) patients continued NAs, and 393 (31.9%) patients discontinued NAs. Continuation of NAs was identified as an independent risk factor for RFS (HR 2.047, 95% CI 1.348\u20133.109,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001 before PSM and HR 2.756, 95% CI 1.537\u20134.942,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001 after PSM) in HBsAg\u2010negative patients. Similarly, subgroup survival analyses showed that NA discontinuation was associated with better RFS (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.029 before PSM and\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001 after PSM) and comparable OS (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.935 before PSM and\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.115 after PSM) than NA continuation in HBsAg\u2010negative patients. The interaction between HBsAg status and continuation or discontinuation of NAs was significant (\n                      <jats:italic>p<\/jats:italic>\n                      for interaction &lt;0.001).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>These findings demonstrate the potential for HBeAg\u2010negative HBV\u2010related HCC patients who have achieved HBsAg seroclearance to discontinue NAs under strict monitoring.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/cam4.70185","type":"journal-article","created":{"date-parts":[[2024,9,2]],"date-time":"2024-09-02T02:00:40Z","timestamp":1725242440000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Effect of nucleos(t)ide analogue discontinuation on the prognosis of\n                    <scp>HBeAg<\/scp>\n                    \u2010negative hepatitis B virus\u2010related hepatocellular carcinoma after hepatectomy: A propensity score matching analysis"],"prefix":"10.1002","volume":"13","author":[{"given":"Ting","family":"Sun","sequence":"first","affiliation":[{"name":"Division of Liver Surgery, Department of General Surgery West China Hospital, Sichuan University  Chengdu P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yiwen","family":"Qiu","sequence":"additional","affiliation":[{"name":"Division of Liver Surgery, Department of General Surgery West China Hospital, Sichuan University  Chengdu P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tao","family":"Wang","sequence":"additional","affiliation":[{"name":"Division of Liver Surgery, Department of General Surgery West China Hospital, Sichuan University  Chengdu P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yi","family":"Yang","sequence":"additional","affiliation":[{"name":"Division of Liver Surgery, Department of General Surgery West China Hospital, Sichuan University  Chengdu P. R. 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China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6966-2665","authenticated-orcid":false,"given":"Wentao","family":"Wang","sequence":"additional","affiliation":[{"name":"Division of Liver Surgery, Department of General Surgery West China Hospital, Sichuan University  Chengdu P. R. 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