{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,27]],"date-time":"2026-06-27T08:39:48Z","timestamp":1782549588873,"version":"3.54.5"},"reference-count":33,"publisher":"Wiley","issue":"18","license":[{"start":{"date-parts":[[2024,9,30]],"date-time":"2024-09-30T00:00:00Z","timestamp":1727654400000},"content-version":"vor","delay-in-days":29,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100009619","name":"Japan Agency for Medical Research and Development","doi-asserted-by":"publisher","award":["JP16ck0106055"],"award-info":[{"award-number":["JP16ck0106055"]}],"id":[{"id":"10.13039\/100009619","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100009619","name":"Japan Agency for Medical Research and Development","doi-asserted-by":"publisher","award":["JP19ck0106321"],"award-info":[{"award-number":["JP19ck0106321"]}],"id":[{"id":"10.13039\/100009619","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100009619","name":"Japan Agency for Medical Research and Development","doi-asserted-by":"publisher","award":["JP22ck0106596"],"award-info":[{"award-number":["JP22ck0106596"]}],"id":[{"id":"10.13039\/100009619","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cancer Medicine"],"published-print":{"date-parts":[[2024,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>In a randomized phase II\/III trial (JCOG1008), weekly cisplatin (40\u2009mg\/m<jats:sup>2<\/jats:sup>) was non\u2010inferior to 3\u2010weekly cisplatin (100\u2009mg\/m<jats:sup>2<\/jats:sup>) for postoperative high\u2010risk head and neck cancer. We investigated how acute kidney injury (AKI), a major dose\u2010limiting toxicity effect of cisplatin, affects overall survival (OS).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We analyzed 251 patients from JCOG1008 receiving chemoradiotherapy. AKI was defined based on AKI Network criteria (serum creatinine increase of \u22650.3\u2009mg\/dL or \u22651.5\u2010fold [\u2265 stage I]) within 30\u2009days after completing chemoradiotherapy. OS in the two arms was compared according to AKI development using the log\u2010rank test.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The total incidence of AKI was lower in the weekly arm than in the 3\u2010weekly arm (38\/122 [31.1%] vs. 56\/129 [43.4%]). Additionally, stage II\/III AKI occurred less frequently in the weekly arm than in the 3\u2010weekly arm (8\/122 [6.6%] vs. 19\/129 [14.7%]). Cisplatin doses were similar in the weekly arm for patients with and without AKI (median, 238.6\u2009mg\/m<jats:sup>2<\/jats:sup> vs. 239.2\u2009mg\/m<jats:sup>2<\/jats:sup>; <jats:italic>p<\/jats:italic>\u2009=\u20090.94), but lower in the 3\u2010weekly arm for those who developed AKI (median, 276.3\u2009mg\/m<jats:sup>2<\/jats:sup> vs. 297.4\u2009mg\/m<jats:sup>2<\/jats:sup>; <jats:italic>p<\/jats:italic>\u2009=\u20090.007). In the weekly arm, there was no difference in OS between patients with and without AKI (hazard ratio [HR], 1.06; 95% confidence interval [CI], 0.53 to 2.10). However, in the 3\u2010weekly arm, patients with AKI had poorer OS than those without AKI (HR, 1.83; 95% CI, 1.04 to 3.21).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>In this supplementary analysis of JCOG1008 data, AKI impacted the OS of patients with head and neck cancer undergoing postoperative chemoradiotherapy in the 3\u2010weekly arm but not in the weekly arm. Our results further endorse the utilization of weekly cisplatin at 40\u2009mg\/m<jats:sup>2<\/jats:sup> in this setting.<\/jats:p><\/jats:sec>","DOI":"10.1002\/cam4.70235","type":"journal-article","created":{"date-parts":[[2024,9,30]],"date-time":"2024-09-30T16:40:02Z","timestamp":1727714402000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Effect of acute kidney injury and overall survival in patients with postoperative head and neck cancer who received chemoradiotherapy with cisplatin: A supplementary analysis of the phase <scp>II<\/scp>\/<scp>III<\/scp> trial of <scp>JCOG1008<\/scp>"],"prefix":"10.1002","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5202-531X","authenticated-orcid":false,"given":"Yoshinori","family":"Imamura","sequence":"first","affiliation":[{"name":"Kobe University Hospital  Kobe 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