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The associations between selected pQTL\u2010SNPs and LUAD risk were evaluated by Female Lung Cancer Consortium in Asia GWAS (FLCCA GWAS). Enzyme linked immunosorbent assay (ELISA) is used to determine the levels of candidate protein.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A total of 7 pQTL\u2010SNPs were significantly associated with altered LUAD risk (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.05). Meanwhile, the expression of their corresponding target proteins were all decreased in both plasma and tumor tissues of LUAD cases, which may play a role of tumor suppressor proteins. After mutation of 3 pQTL\u2010SNPs (rs7683000, rs73224660, and rs2776937), the expression of corresponding target proteins BST1 and NRP1 decreased, and as potential tumor suppressor proteins, which may promote tumorigenesis and further increasing the risk of developing LUAD (OR &gt;1, <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.05); while after mutation the other pQTL\u2010SNP rs62069916, the corresponding target protein APOH expression was increased, while as a potential tumor suppressor protein, which may inhibit tumorigenesis and further reduced the risk of developing LUAD (OR &lt;1, <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.05). In addition, the expression of NRP1 and APOH were significant decreased in LUAD cell lines and validated in plasma of LUAD patients.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>A total of 4 pQTL\u2010SNPs (rs7683000, rs73224660, rs2776937, and rs62069916) may associate with altered LUAD risk by regulating the expression of target proteins (BST1, NRP1, and APOH) after mutation.<\/jats:p><\/jats:sec>","DOI":"10.1002\/cam4.70247","type":"journal-article","created":{"date-parts":[[2024,9,18]],"date-time":"2024-09-18T11:32:18Z","timestamp":1726659138000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Identification of novel <scp>pQTL<\/scp>\u2010<scp>SNPs<\/scp> associated with lung adenocarcinoma risk: A multi\u2010stage study"],"prefix":"10.1002","volume":"13","author":[{"given":"Yutong","family":"Wu","sequence":"first","affiliation":[{"name":"Department of Epidemiology School of Public 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