{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,30]],"date-time":"2025-07-30T08:05:48Z","timestamp":1753862748923,"version":"3.41.2"},"reference-count":9,"publisher":"Wiley","issue":"18","license":[{"start":{"date-parts":[[2024,9,24]],"date-time":"2024-09-24T00:00:00Z","timestamp":1727136000000},"content-version":"vor","delay-in-days":23,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cancer Medicine"],"published-print":{"date-parts":[[2024,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Adrenomedullin (AM) is a multifunctional peptide which under basal conditions mainly regulates vasodilation and maintains vascular integrity but is also implicated in the pathogenesis of several malignancies, including multiple myeloma (MM). It has been shown that adrenomedullin is expressed by human myeloma cell lines and that it enhances MM\u2010driven angiogenesis. However, the clinical impact of AM remains unknown.<\/jats:p><\/jats:sec><jats:sec><jats:title>Materials and Methods<\/jats:title><jats:p>On that basis, we enrolled 32 newly diagnosed multiple myeloma patients (NDMM) and studied the potential of AM as a prognostic biomarker.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>We report that elevated levels of AM trend with suboptimal treatment response and inferior survival of NDMM patients.<\/jats:p><\/jats:sec>","DOI":"10.1002\/cam4.70250","type":"journal-article","created":{"date-parts":[[2024,9,24]],"date-time":"2024-09-24T13:13:43Z","timestamp":1727183623000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Angiogenesis and multiple myeloma: Exploring prognostic potential of adrenomedullin"],"prefix":"10.1002","volume":"13","author":[{"given":"Angelos","family":"Giannakoulas","sequence":"first","affiliation":[{"name":"Laboratory of Hematology Department, Faculty of Medicine University of Thessaly  Larissa Greece"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Panagiotis","family":"Stoikos","sequence":"additional","affiliation":[{"name":"Laboratory of Hematology Department, Faculty of Medicine University of Thessaly  Larissa Greece"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Evangelia","family":"Kouvata","sequence":"additional","affiliation":[{"name":"Hematology Department University Hospital of Larissa  Larissa Greece"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Katerina M.","family":"Kontouli","sequence":"additional","affiliation":[{"name":"Laboratory of Hygiene and Epidemiology, Faculty of Medicine University of Thessaly  Larissa Greece"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Georgios","family":"Fotiadis","sequence":"additional","affiliation":[{"name":"Hematology Department University Hospital of Larissa  Larissa Greece"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Georgia","family":"Stefani","sequence":"additional","affiliation":[{"name":"Hematology Department University Hospital of Larissa  Larissa Greece"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Grigorios D.","family":"Amoutzias","sequence":"additional","affiliation":[{"name":"Bioinformatics Laboratory, Department of Biochemistry &amp; Biotechnology School of Health Sciences, University of Thessaly  Larissa Greece"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"George","family":"Vassilopoulos","sequence":"additional","affiliation":[{"name":"Hematology Department University Hospital of Larissa  Larissa Greece"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0003-3482-4286","authenticated-orcid":false,"given":"Nikolaos","family":"Giannakoulas","sequence":"additional","affiliation":[{"name":"Hematology Department University Hospital of Larissa  Larissa Greece"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2024,9,24]]},"reference":[{"issue":"7","key":"e_1_2_5_2_1","first-page":"2210","article-title":"Bone marrow angiogenesis in 400 patients with monoclonal gammopathy of undetermined significance, multiple myeloma, and primary amyloidosis","volume":"8","author":"Rajkumar SV","year":"2002","journal-title":"Clin Cancer Res"},{"key":"e_1_2_5_3_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12307-011-0072-9"},{"key":"e_1_2_5_4_1","doi-asserted-by":"publisher","DOI":"10.1038\/leu.2013.76"},{"key":"e_1_2_5_5_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41440-021-00806-y"},{"key":"e_1_2_5_6_1","doi-asserted-by":"publisher","DOI":"10.1006\/bbrc.1993.1451"},{"key":"e_1_2_5_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0167-0115(03)00037-5"},{"key":"e_1_2_5_8_1","doi-asserted-by":"publisher","DOI":"10.3389\/fonc.2024.1390105"},{"key":"e_1_2_5_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1470-2045(14)70442-5"},{"key":"e_1_2_5_10_1","doi-asserted-by":"publisher","DOI":"10.1006\/meth.2001.1262"}],"container-title":["Cancer Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/cam4.70250","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,5,30]],"date-time":"2025-05-30T12:35:06Z","timestamp":1748608506000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/cam4.70250"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,9]]},"references-count":9,"journal-issue":{"issue":"18","published-print":{"date-parts":[[2024,9]]}},"alternative-id":["10.1002\/cam4.70250"],"URL":"https:\/\/doi.org\/10.1002\/cam4.70250","archive":["Portico"],"relation":{},"ISSN":["2045-7634","2045-7634"],"issn-type":[{"type":"print","value":"2045-7634"},{"type":"electronic","value":"2045-7634"}],"subject":[],"published":{"date-parts":[[2024,9]]},"assertion":[{"value":"2024-07-25","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-09-11","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-09-24","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e70250"}}