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Tattooing can result in long\u2010term exposure to carcinogens and inflammatory and immune responses.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We examined tattooing and risk of hematologic cancers in a population\u2010based case\u2013control study with 820 cases diagnosed 2019\u20132021 and 8200 frequency\u2010matched controls, ages 18\u201379\u2009years. We calculated odds ratios (OR) and 95% confidence intervals (CI) using multivariable\u2010adjusted logistic regression models.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The prevalence of tattooing was 22% among Hodgkin lymphoma (HL) cases, 11% among non\u2010Hodgkin lymphoma (NHL) cases, 16% among myeloid neoplasm cases, and 15% among controls. Though there were no clear patterns of associations between ever receiving a tattoo and risk of HL, NHL, or myeloid neoplasms overall, in analyses restricted to ages 20\u201360\u2009years, ever receiving a tattoo (OR 2.06 [95% CI 1.01, 4.20]) and receiving a tattoo 10+\u2009years prior (OR 2.64 [95% CI 1.23, 5.68]) were associated with an aggregated group of rarer mature B\u2010cell NHLs. We also observed elevated risks for a 10+\u2009year latency for myelodysplastic syndromes and chronic myeloid leukemia (OR 1.48 [95% CI 0.40, 5.41], and OR 1.24 [95% CI 0.45, 3.43], respectively).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Though estimates were imprecise, we found some suggestive evidence that tattooing may be associated with an increased risk of certain hematologic cancer subtypes. With an estimated 46% prevalence of tattooing in US individuals ages 30\u201349, additional studies are needed to understand the degree to which these exposures may be associated with hematologic cancer risk.<\/jats:p><\/jats:sec>","DOI":"10.1002\/cam4.70260","type":"journal-article","created":{"date-parts":[[2024,10,24]],"date-time":"2024-10-24T06:39:05Z","timestamp":1729751945000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Tattoos and Risk of Hematologic Cancer: A Population\u2010Based Case\u2013Control Study in Utah"],"prefix":"10.1002","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2742-3081","authenticated-orcid":false,"given":"Rachel\u00a0D.","family":"McCarty","sequence":"first","affiliation":[{"name":"Huntsman Cancer Institute, University of Utah  Salt Lake City Utah USA"},{"name":"Department of Population Health Sciences Spencer Fox Eccles School of Medicine University of Utah 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