{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,27]],"date-time":"2026-03-27T15:18:50Z","timestamp":1774624730560,"version":"3.50.1"},"reference-count":30,"publisher":"Wiley","issue":"19","license":[{"start":{"date-parts":[[2024,10,9]],"date-time":"2024-10-09T00:00:00Z","timestamp":1728432000000},"content-version":"vor","delay-in-days":8,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100003645","name":"National Cancer Center","doi-asserted-by":"publisher","award":["NCC 2243330\u20101"],"award-info":[{"award-number":["NCC 2243330\u20101"]}],"id":[{"id":"10.13039\/501100003645","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cancer Medicine"],"published-print":{"date-parts":[[2024,10]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:title>Purpose<\/jats:title><jats:p>The prognosis of microinvasive breast cancer (MIBC) is controversial, with a high reported rate of local recurrence (LR). This study aimed to evaluate the characteristics, treatments, and prognosis of patients with MIBC compared to those with carcinoma in\u00a0situ (CIS) or early invasive cancer.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Patients who diagnosed with CIS or stage I breast cancer were retrospectively enrolled. Using the Kaplan\u2013Meier method, local recurrence\u2010free survival (LRFS), systemic recurrence\u2010free survival (SRFS), and cancer\u2010specific survival (CSS) were compared according to T stage. The prognostic factors associated with LRFS were identified using the Cox proportional hazards model.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>According to T stage, 517 (21.6%), 200 (8.4%), 207 (8.7%), 363 (15.2%), and 1101 (46.1%) patients had Tis, T1mi, T1a, T1b, and T1c tumors, respectively. The proportion of human epidermal growth factor receptor 2\u2010positive tumors was significantly higher in patients with MIBC (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.0001). The administered adjuvant treatments also showed differences according to T stage (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.0001). During the 73\u2010month median follow\u2010up period, patients with MIBC showed significantly worse LRFS than those with T1a or T1c tumors (<jats:italic>p<\/jats:italic>\u2009=\u20090.002). There was no significant difference in SRFS and CSS. In the Cox regression analysis, tumor multiplicity (<jats:italic>p<\/jats:italic>\u2009=\u20090.017), Ki\u201067 (<jats:italic>p<\/jats:italic>\u2009=\u20090.025), cancer subtype (<jats:italic>p<\/jats:italic>\u2009=\u20090.034), adjuvant endocrine therapy (<jats:italic>p<\/jats:italic>\u2009=\u20090.003), and adjuvant radiation therapy (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.0001) were significant prognostic factors associated with LRFS.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The risk of LR was higher in patients with MIBC than in those with small invasive breast cancer. Therefore, if indicated, adjuvant endocrine and radiation therapies should be administered to prevent undertreatment in patients with MIBC.<\/jats:p><\/jats:sec>","DOI":"10.1002\/cam4.70297","type":"journal-article","created":{"date-parts":[[2024,10,9]],"date-time":"2024-10-09T12:16:17Z","timestamp":1728476177000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Unveiling the Clinical Path of Microinvasive Breast Cancer: A Comparative Study With Tis\u2010T1 Breast Cancer"],"prefix":"10.1002","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6373-7411","authenticated-orcid":false,"given":"Ran","family":"Song","sequence":"first","affiliation":[{"name":"Department of Surgery Konyang University Hospital, Konyang University College of Medicine  Daejeon Republic of 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