{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,13]],"date-time":"2026-01-13T09:25:40Z","timestamp":1768296340602,"version":"3.49.0"},"reference-count":40,"publisher":"Wiley","issue":"21","license":[{"start":{"date-parts":[[2024,11,8]],"date-time":"2024-11-08T00:00:00Z","timestamp":1731024000000},"content-version":"vor","delay-in-days":7,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100003625","name":"Ministry of Health and Welfare","doi-asserted-by":"publisher","award":["MOHW 111\u2010TDU\u2010B\u2010221\u2010114002"],"award-info":[{"award-number":["MOHW 111\u2010TDU\u2010B\u2010221\u2010114002"]}],"id":[{"id":"10.13039\/501100003625","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003625","name":"Ministry of Health and Welfare","doi-asserted-by":"publisher","award":["MOHW112\u2010TDU\u2010B\u2010222\u201012"],"award-info":[{"award-number":["MOHW112\u2010TDU\u2010B\u2010222\u201012"]}],"id":[{"id":"10.13039\/501100003625","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100020595","name":"National Science and Technology Council","doi-asserted-by":"publisher","award":["MOST 109\u20102314\u2010B\u2010182A\u2010132 \u2010MY3"],"award-info":[{"award-number":["MOST 109\u20102314\u2010B\u2010182A\u2010132 \u2010MY3"]}],"id":[{"id":"10.13039\/100020595","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100020595","name":"National Science and Technology Council","doi-asserted-by":"publisher","award":["105\u20102314\u2010B\u2010182A\u2010"],"award-info":[{"award-number":["105\u20102314\u2010B\u2010182A\u2010"]}],"id":[{"id":"10.13039\/100020595","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100012553","name":"Chang Gung Memorial Hospital","doi-asserted-by":"publisher","award":["CMRPG3J0271\u20102"],"award-info":[{"award-number":["CMRPG3J0271\u20102"]}],"id":[{"id":"10.13039\/100012553","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100012553","name":"Chang Gung Memorial Hospital","doi-asserted-by":"publisher","award":["CMRPG3J0281\u20102"],"award-info":[{"award-number":["CMRPG3J0281\u20102"]}],"id":[{"id":"10.13039\/100012553","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cancer Medicine"],"published-print":{"date-parts":[[2024,11]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>This study aimed to identify the clinical predictors for the response of patients with mCRPC to ARATs.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Materials and Methods<\/jats:title>\n                    <jats:p>We retrospectively collected data on consecutive patients who were diagnosed with mCRPC and underwent ARAT treatment during this stage of the disease. Clinical parameters were obtained through medical chart reviews. ARAT failure was defined as a continuous increase in the serum prostate\u2010specific antigen (PSA) level above nadir to &gt;\u20092\u2009ng\/mL, accompanied by radiographic progression. ARAT failure\u2010free survival and overall survival were assessed through Kaplan\u2013Meier survival analysis and Cox regression survival analysis. Nomogram analysis based on significant predictors of ARAT failure\u2010free survival was performed.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>In total, 319 patients with mCRPC who underwent ARAT were included. Multivariate analysis revealed that age, International Society of Urological Pathology (ISUP) grading, and chemotherapy\u2010na\u00efve status were significant predictors of ARAT failure\u2010free survival. For overall survival, age, ISUP grading, and nadir PSA level during androgen deprivation therapy (ADT) were significant predictors. Through nomogram analysis based on age, ISUP grading, and chemotherapy\u2010na\u00efve status, the likelihood of ARAT duration being more or less than 1\u2009year could be predicted.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>For mCRPC patients, being older, having ISUP Grade 5 cancer, and having a history of chemotherapy were associated with a shorter duration of response to next\u2010line ARATs. Therefore, other therapeutic agents should be prioritized for such patients. Notably, among the included patients, those who were older, had a higher ISUP grade and a higher nadir PSA level during ADT exhibited worse overall survival.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/cam4.70319","type":"journal-article","created":{"date-parts":[[2024,11,9]],"date-time":"2024-11-09T00:36:11Z","timestamp":1731112571000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Nomogram Analysis for Predicting Response to Androgen\u2010Receptor\u2010Axis\u2010Targeted Therapies in Patients With Metastatic Castration\u2010Resistant Prostate Cancer"],"prefix":"10.1002","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4832-0113","authenticated-orcid":false,"given":"I\u2010Hung","family":"Shao","sequence":"first","affiliation":[{"name":"Department of Surgery, Division of Urology Chang Gung Memorial Hospital, Linkou Branch  Taoyuan Taiwan"},{"name":"School of Medicine, College of Medicine Chang Gung University  Taoyuan Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hsiang\u2010Shen","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Pathology Chang Gung Memorial Hospital, Linkou Branch  Taoyuan Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chin\u2010Hsuan","family":"Hsieh","sequence":"additional","affiliation":[{"name":"Department of Surgery, Division of Urology Chang Gung Memorial Hospital, Linkou Branch  Taoyuan Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tsung\u2010Lin","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Surgery, Division of Urology Chang Gung Memorial Hospital, Linkou Branch  Taoyuan Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ying\u2010Hsu","family":"Chang","sequence":"additional","affiliation":[{"name":"School of Medicine, College of Medicine Chang Gung University  Taoyuan Taiwan"},{"name":"Department of Surgery, Division of Urology New Taipei Municipal TuCheng Hospital  New Taipei Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Liang\u2010Kang","family":"Huang","sequence":"additional","affiliation":[{"name":"Department of Surgery, Division of Urology Chang Gung Memorial Hospital, Linkou Branch  Taoyuan Taiwan"},{"name":"School of Medicine, College of Medicine Chang Gung University  Taoyuan Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuan\u2010Cheng","family":"Chu","sequence":"additional","affiliation":[{"name":"Department of Surgery, Division of Urology Chang Gung Memorial Hospital, Linkou Branch  Taoyuan Taiwan"},{"name":"School of Medicine, College of Medicine Chang Gung University  Taoyuan Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hung\u2010Chen","family":"Kan","sequence":"additional","affiliation":[{"name":"Department of Surgery, Division of Urology Chang Gung Memorial Hospital, Linkou Branch  Taoyuan Taiwan"},{"name":"School of Medicine, College of Medicine Chang Gung University  Taoyuan Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Po\u2010Hung","family":"Lin","sequence":"additional","affiliation":[{"name":"Department of Surgery, Division of Urology Chang Gung Memorial Hospital, Linkou Branch  Taoyuan Taiwan"},{"name":"School of Medicine, College of Medicine Chang Gung University  Taoyuan Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kai\u2010Jie","family":"Yu","sequence":"additional","affiliation":[{"name":"Department of Surgery, Division of Urology Chang Gung Memorial Hospital, Linkou Branch  Taoyuan Taiwan"},{"name":"School of Medicine, College of Medicine Chang Gung University  Taoyuan Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chun\u2010Te","family":"Wu","sequence":"additional","affiliation":[{"name":"Department of Surgery, Division of Urology Chang Gung Memorial Hospital, Linkou Branch  Taoyuan Taiwan"},{"name":"School of Medicine, College of Medicine Chang Gung University  Taoyuan Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cheng\u2010Keng","family":"Chuang","sequence":"additional","affiliation":[{"name":"Department of Surgery, Division of Urology Chang Gung Memorial Hospital, Linkou Branch  Taoyuan Taiwan"},{"name":"School of Medicine, College of Medicine Chang Gung University  Taoyuan Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"See\u2010Tong","family":"Pang","sequence":"additional","affiliation":[{"name":"Department of Surgery, Division of Urology Chang Gung Memorial Hospital, Linkou Branch  Taoyuan Taiwan"},{"name":"School of Medicine, College of Medicine Chang Gung University  Taoyuan Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2024,11,8]]},"reference":[{"key":"e_1_2_12_2_1","doi-asserted-by":"publisher","DOI":"10.3322\/caac.21708"},{"key":"e_1_2_12_3_1","doi-asserted-by":"publisher","DOI":"10.1007\/s40265\u2010019\u20101060\u20105"},{"key":"e_1_2_12_4_1","doi-asserted-by":"publisher","DOI":"10.3322\/caac.21565"},{"key":"e_1_2_12_5_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.1946.02870240008003"},{"key":"e_1_2_12_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/iju.14303"},{"key":"e_1_2_12_7_1","doi-asserted-by":"publisher","DOI":"10.1101\/cshperspect.a030452"},{"key":"e_1_2_12_8_1","doi-asserted-by":"publisher","DOI":"10.3389\/fonc.2019.00858"},{"key":"e_1_2_12_9_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0139440"},{"key":"e_1_2_12_10_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12325\u2010021\u201001823\u20106"},{"key":"e_1_2_12_11_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41391\u2010021\u201000318\u20103"},{"key":"e_1_2_12_12_1","doi-asserted-by":"publisher","DOI":"10.3390\/cancers13030509"},{"key":"e_1_2_12_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/s1470\u20102045(14)71205\u20107"},{"key":"e_1_2_12_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.eururo.2020.04.061"},{"key":"e_1_2_12_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.eururo.2016.07.032"},{"key":"e_1_2_12_16_1","unstructured":"Janssen \u201cZYTIGA\u00ae (abiraterone acetate) \u201d2015. US Prescribing Information."},{"key":"e_1_2_12_17_1","unstructured":"Astellas \u201cXTANDI\u00ae (enzalutamide) \u201d2014. US Prescribing Information."},{"key":"e_1_2_12_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.juro.2018.04.083"},{"key":"e_1_2_12_19_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa040720"},{"key":"e_1_2_12_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/s0140\u20106736(10)61389\u2010x"},{"key":"e_1_2_12_21_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1014618"},{"key":"e_1_2_12_22_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1207506"},{"key":"e_1_2_12_23_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1213755"},{"key":"e_1_2_12_24_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa2107322"},{"key":"e_1_2_12_25_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa2022485"},{"key":"e_1_2_12_26_1","doi-asserted-by":"publisher","DOI":"10.1200\/jco.20.01035"},{"key":"e_1_2_12_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.eururo.2020.09.042"},{"key":"e_1_2_12_28_1","doi-asserted-by":"publisher","DOI":"10.6004\/jnccn.2021.0008"},{"key":"e_1_2_12_29_1","doi-asserted-by":"publisher","DOI":"10.1056\/nejm198908173210702"},{"key":"e_1_2_12_30_1","doi-asserted-by":"publisher","DOI":"10.1016\/s0140\u20106736(14)61947\u20104"},{"key":"e_1_2_12_31_1","doi-asserted-by":"publisher","DOI":"10.1111\/iju.13512"},{"key":"e_1_2_12_32_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12032\u2010019\u20101332\u20107"},{"key":"e_1_2_12_33_1","doi-asserted-by":"publisher","DOI":"10.1016\/s1470\u20102045(12)70379\u20100"},{"key":"e_1_2_12_34_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1405095"},{"issue":"2","key":"e_1_2_12_35_1","first-page":"1057","article-title":"Predictive Factors for Response to Abiraterone in Metastatic Castration Refractory Prostate Cancer","volume":"35","author":"Afshar M.","year":"2015","journal-title":"Anticancer Research"},{"key":"e_1_2_12_36_1","doi-asserted-by":"publisher","DOI":"10.1002\/pros.23141"},{"key":"e_1_2_12_37_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clgc.2019.12.019"},{"key":"e_1_2_12_38_1","doi-asserted-by":"publisher","DOI":"10.1177\/107327480901600210"},{"key":"e_1_2_12_39_1","doi-asserted-by":"publisher","DOI":"10.1200\/cci.23.00057"},{"key":"e_1_2_12_40_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2011.02.013"},{"key":"e_1_2_12_41_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.aab4082"}],"container-title":["Cancer Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/cam4.70319","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,12,9]],"date-time":"2025-12-09T12:55:19Z","timestamp":1765284919000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/cam4.70319"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,11]]},"references-count":40,"journal-issue":{"issue":"21","published-print":{"date-parts":[[2024,11]]}},"alternative-id":["10.1002\/cam4.70319"],"URL":"https:\/\/doi.org\/10.1002\/cam4.70319","archive":["Portico"],"relation":{},"ISSN":["2045-7634","2045-7634"],"issn-type":[{"value":"2045-7634","type":"print"},{"value":"2045-7634","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,11]]},"assertion":[{"value":"2023-12-08","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-09-28","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-11-08","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e70319"}}