{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T12:49:24Z","timestamp":1790858964046,"version":"4.1.0"},"reference-count":82,"publisher":"Wiley","issue":"20","license":[{"start":{"date-parts":[[2024,10,21]],"date-time":"2024-10-21T00:00:00Z","timestamp":1729468800000},"content-version":"vor","delay-in-days":20,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cancer Medicine"],"published-print":{"date-parts":[[2024,10]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>\n                      Rearrangements of the histone\u2010lysine\u2010N\u2010methyltransferase\n                      <jats:italic>(KMT2A)<\/jats:italic>\n                      , previously referred to as mixed\u2010lineage leukemia\n                      <jats:italic>(MLL),<\/jats:italic>\n                      are among the most common chromosomal abnormalities in patients with acute myeloid leukemia (AML) and acute lymphoblastic leukemia (ALL), involving numerous different fusion partners.\n                      <jats:italic>KMT2A<\/jats:italic>\n                      \u2010rearranged (\n                      <jats:italic>KMT2A<\/jats:italic>\n                      \u2010r) leukemia is characterized by a rapid onset, aggressive progression, and significantly worse prognosis compared to non\u2010\n                      <jats:italic>KMT2A<\/jats:italic>\n                      \u2010r leukemias. Even with contemporary chemotherapeutic treatments and hematopoietic stem cell transplantations (HSCT), patients with\n                      <jats:italic>KMT2A<\/jats:italic>\n                      \u2010r leukemia typically experience poor outcomes and limited responses to these therapies.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>\n                      This review aims to consolidate recent studies on the general gene characteristics and associated mechanisms of\n                      <jats:italic>KMT2A\u2010<\/jats:italic>\n                      r acute leukemia, as well as the cytogenetics, immunophenotype, clinical presentation, and risk stratification of both\n                      <jats:italic>KMT2A\u2010<\/jats:italic>\n                      r\u2010AML and\n                      <jats:italic>KMT2A<\/jats:italic>\n                      \u2010r\u2010ALL. Particularly, the treatment targets in\n                      <jats:italic>KMT2A<\/jats:italic>\n                      \u2010r acute leukemia are examined.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      A comprehensive review was carried out by systematically synthesizing existing literature on PubMed, using the combination of the keywords \u2018\n                      <jats:italic>KMT2A<\/jats:italic>\n                      \u2010rearranged acute leukemia\u2019, \u2018lymphoblastic leukemia\u2019, \u2018myeloid leukemia\u2019, and \u2018therapy\u2019. The available studies were screened for selection based on quality and relevance.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>\n                      Studies indicate that\n                      <jats:italic>KMT2A<\/jats:italic>\n                      rearrangements are present in over 70% of infant leukemia cases, approximately 10% of adult AML cases, and numerous instances of secondary acute leukemias, making it a disease of critical concern to clinicians and researchers alike. The future of\n                      <jats:italic>KMT2A<\/jats:italic>\n                      \u2010r acute leukemia research is characterized by an expanding knowledge of the disease's biology, with an emphasis on personalized therapies, immunotherapies, genomic advancements, and innovative therapeutic combinations. The overarching aim is to enhance patient outcomes, lessen the disease burden, and elevate the quality of life for those affected. Ongoing research and clinical trials in this area continue to offer promising opportunities for refining treatment strategies and improving patient prognosis.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/cam4.70326","type":"journal-article","created":{"date-parts":[[2024,10,21]],"date-time":"2024-10-21T03:39:45Z","timestamp":1729481985000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":15,"title":["Recent Developments and Evolving Therapeutic Strategies in\n                    <scp>\n                      <i>KMT2A<\/i>\n                    <\/scp>\n                    \u2010Rearranged Acute Leukemia"],"prefix":"10.1002","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3316-694X","authenticated-orcid":false,"given":"Lei","family":"Yin","sequence":"first","affiliation":[{"name":"Department of Clinical Laboratory Children's Hospital of Soochow University  Suzhou 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