{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,15]],"date-time":"2026-09-15T10:15:08Z","timestamp":1789467308759,"version":"build-2803163510"},"reference-count":49,"publisher":"Wiley","issue":"21","license":[{"start":{"date-parts":[[2024,11,6]],"date-time":"2024-11-06T00:00:00Z","timestamp":1730851200000},"content-version":"vor","delay-in-days":5,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100006108","name":"National Center for Advancing Translational Sciences","doi-asserted-by":"publisher","award":["UL1 TR001863"],"award-info":[{"award-number":["UL1 TR001863"]}],"id":[{"id":"10.13039\/100006108","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cancer Medicine"],"published-print":{"date-parts":[[2024,11]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Non\u2010Hodgkin lymphoma (NHL) is one of the most common haematologic malignancies in the world. Despite substantial efforts to identify causes and risk factors for NHL, its aetiology is largely unclear. Autoimmune diseases have long been considered potential risk factors for NHL. We carried out Mendelian randomisation (MR) analyses to examine whether genetically predicted susceptibility to ten autoimmune diseases (Beh\u00e7et's disease, coeliac disease, dermatitis herpetiformis, lupus, psoriasis, rheumatoid arthritis, sarcoidosis, Sj\u00f6gren's syndrome, systemic sclerosis, and type 1 diabetes) is associated with risk of NHL.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Two\u2010sample MR was performed using publicly available summary statistics from cohorts of European ancestry. For NHL and four NHL subtypes, we used data from UK Biobank, Kaiser Permanente cohorts, and FinnGen studies.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Negative associations between type 1 diabetes and sarcoidosis and the risk of NHL were observed (odds ratio [OR] 0.95, 95% confidence interval [CI]: 0.92\u20130.98,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20095\u2009\u00d7\u200910\n                      <jats:sup>\u22123<\/jats:sup>\n                      , and OR 0.92, 95% CI: 0.85\u20130.99,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20092.8\u2009\u00d7\u200910\n                      <jats:sup>\u22122<\/jats:sup>\n                      , respectively). These findings were supported by the sensitivity analyses accounting for potential pleiotropy and weak instrument bias. No significant associations were found between the other eight autoimmune diseases and NHL risk.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>These findings suggest that genetically predicted susceptibility to type 1 diabetes, and to some extent sarcoidosis, might reduce the risk of NHL. However, future studies with different datasets, approaches, and populations are warranted to further examine the potential associations between these autoimmune diseases and the risk of NHL.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/cam4.70327","type":"journal-article","created":{"date-parts":[[2024,11,7]],"date-time":"2024-11-07T00:43:52Z","timestamp":1730940232000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Autoimmune Diseases and Risk of Non\u2010Hodgkin Lymphoma: A Mendelian Randomisation Study"],"prefix":"10.1002","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5256-0646","authenticated-orcid":false,"given":"Xiaoting","family":"Shi","sequence":"first","affiliation":[{"name":"Department of Environmental Health Sciences Yale School of Public Health  New Haven Connecticut USA"},{"name":"Yale Center for Perinatal, Pediatric, and Environmental Epidemiology Yale School of Public Health  New Haven Connecticut USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2816-6905","authenticated-orcid":false,"given":"Joshua\u00a0D.","family":"Wallach","sequence":"additional","affiliation":[{"name":"Department of Epidemiology, Rollins School of Public Health Emory University  Atlanta Georgia USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9472-8032","authenticated-orcid":false,"given":"Xiaomei","family":"Ma","sequence":"additional","affiliation":[{"name":"Department of Chronic Diseases Epidemiology Yale School of Public Health  New Haven Connecticut USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9581-7384","authenticated-orcid":false,"given":"Tormod","family":"Rogne","sequence":"additional","affiliation":[{"name":"Yale Center for Perinatal, Pediatric, and Environmental Epidemiology Yale School of Public Health  New Haven Connecticut USA"},{"name":"Department of Chronic Diseases Epidemiology Yale School of Public Health  New Haven Connecticut USA"},{"name":"Department of Community Medicine and Global Health University of Oslo  Oslo Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,11,6]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.3322\/caac.21763"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.34163"},{"key":"e_1_2_11_4_1","first-page":"11","article-title":"Epidemiology and Etiology of Leukemia and Lymphoma","volume":"10","author":"Bispo J. 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