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Families commonly support YBCS, particularly during treatment, but little is known about long\u2010term YBCS and family member QOL. The purpose of this study was to identify demographic, clinical, and psychosocial predictors of physical and mental QOL in YBCS and biological relatives and investigate associations between their QOL (i.e., QOL interdependence).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This secondary data analysis includes a random sample of long\u2010term YBCS (\u2264\u200945\u2009years old at diagnosis) and up to two female relatives at baseline (post\u2010treatment) and 18\u2010month follow\u2010up. The sample consists of 189 dyads (YBCS and one relative) and 121 triads (YBCS and two relatives). Actor\u2010partner interdependence models (APIMs) were used to estimate the influence of YBCS's and relatives' demographic, clinical, and psychosocial factors on their own QOL (actor effects) and the other persons' QOL (partner effects).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>For YBCS and relatives, QOL at the baseline was associated with their QOL at 18\u2010months. YBCS's perceived cancer risk was associated with their own and relatives' QOL. Older relatives' physical QOL at baseline was associated with younger relatives' physical QOL at follow\u2010up. Age, race, marital status, years since diagnosis, education, out\u2010of\u2010pocket costs of care, routine sources of care, income, family support, fear of recurrence, anxiety, and depression were also significant predictors of QOL.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Findings revealed independent and interdependent effects on QOL. These predictors point to potential targets of support for families.<\/jats:p><\/jats:sec><jats:sec><jats:title>Trial Registration<\/jats:title><jats:p><jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink:href=\"http:\/\/clinicaltrials.gov\">ClinicalTrials.gov<\/jats:ext-link> ID: NCT01612338<\/jats:p><\/jats:sec>","DOI":"10.1002\/cam4.70328","type":"journal-article","created":{"date-parts":[[2024,10,29]],"date-time":"2024-10-29T12:37:29Z","timestamp":1730205449000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Predictors and Interdependence of Quality of Life in a Random Sample of Long\u2010Term Young Breast Cancer Survivors and Their Biological Relatives"],"prefix":"10.1002","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1709-3912","authenticated-orcid":false,"given":"Katrina\u00a0R.","family":"Ellis","sequence":"first","affiliation":[{"name":"School of Social Work University of Michigan  Ann Arbor Michigan USA"},{"name":"School of Public Health University of Michigan  Ann Arbor Michigan USA"},{"name":"Research Center for Group Dynamics Institute for Social Research, University of Michigan  Ann Arbor Michigan USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Helen","family":"Koechlin","sequence":"additional","affiliation":[{"name":"University of Zurich  Z\u00fcrich Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marion","family":"Rudaz","sequence":"additional","affiliation":[{"name":"Department of Clinical Research University of Basel  Basel Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2243-6203","authenticated-orcid":false,"given":"Lynette\u00a0Hammond","family":"Gerido","sequence":"additional","affiliation":[{"name":"Case Western University  Cleveland Ohio USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hillary\u00a0K.","family":"Hecht","sequence":"additional","affiliation":[{"name":"University of North Carolina at Chapel Hill  Chapel Hill North Carolina USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carly","family":"Jones","sequence":"additional","affiliation":[{"name":"Michigan Medicine University of Michigan  Ann Arbor Michigan USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dolapo","family":"Raji","sequence":"additional","affiliation":[{"name":"School of Public Health University of Michigan  Ann Arbor Michigan USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laurel","family":"Northouse","sequence":"additional","affiliation":[{"name":"School of Nursing University of Michigan  Ann Arbor Michigan USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3903-3750","authenticated-orcid":false,"given":"Maria","family":"Katapodi","sequence":"additional","affiliation":[{"name":"Department of Clinical Research University of Basel  Basel Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,10,29]]},"reference":[{"key":"e_1_2_13_2_1","doi-asserted-by":"publisher","DOI":"10.3322\/caac.21412"},{"key":"e_1_2_13_3_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2014.12483"},{"key":"e_1_2_13_4_1","unstructured":"Surveillance Epidemiology and End Results (SEER) Program.\u201cCancer Stat Facts: Female Breast Cancer \u201d2021."},{"key":"e_1_2_13_5_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2011.188"},{"key":"e_1_2_13_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/cam4.1766"},{"key":"e_1_2_13_7_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10552-016-0726-5"},{"key":"e_1_2_13_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/jmwh.13012"},{"key":"e_1_2_13_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejca.2003.12.007"},{"key":"e_1_2_13_10_1","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.28737"},{"key":"e_1_2_13_11_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11136-021-02895-1"},{"key":"e_1_2_13_12_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2011.39.5798"},{"key":"e_1_2_13_13_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00520-015-2840-4"},{"key":"e_1_2_13_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.soncn.2012.09.006"},{"key":"e_1_2_13_15_1","doi-asserted-by":"publisher","DOI":"10.1037\/14344-003"},{"key":"e_1_2_13_16_1","unstructured":"J. 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