{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,16]],"date-time":"2026-07-16T17:49:28Z","timestamp":1784224168910,"version":"3.55.0"},"reference-count":28,"publisher":"Wiley","issue":"21","license":[{"start":{"date-parts":[[2024,11,5]],"date-time":"2024-11-05T00:00:00Z","timestamp":1730764800000},"content-version":"vor","delay-in-days":4,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cancer Medicine"],"published-print":{"date-parts":[[2024,11]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Young patients \u2264\u200950\u2009years old with multiple myeloma (MM) account for about 10% of cases and are underrepresented in the literature.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We explored disease characteristics, treatments, and outcomes following modern therapies of young MM patients using the Canadian Myeloma Research Group (CMRG) database. We included 493 patients \u2264\u200950\u2009years old diagnosed with MM or plasma cell leukemia without concurrent amyloidosis or POEMS syndrome from January 1, 2010, to July 1, 2022.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      The median age was 46\u2009years old (range: 25.6\u201350). Most patients fell into the R\u2010ISS II category (72.7%), and 24.1% had high\u2010risk cytogenetics. The majority of patients (89.9%) received a proteasome inhibitor\u2010based first\u2010line treatment, 92.1% received a stem cell transplant, and 65.6% had maintenance therapy post\u2013autologous stem cell transplant (ASCT). Median follow\u2010up from initial treatment to patients' last follow\u2010up was 48.5 (range: 0\u2013155) months. Median progression\u2010free survival (PFS) was 45.0\u2009months (95% CI: 40.2\u201350.0). Maintenance therapy post\u2010ASCT improved median PFS to 52.3\u2009months (95% CI: 43.1\u201368.2), compared to 23.6\u2009months (95% CI: 20.0\u201334.8) without maintenance\u00a0[\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001].\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Although the overall survival has not yet been reached in this young population, our reported median PFS of only 45 months highlights the urgent need to develop innovative treatments to induce more profound and durable responses.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/cam4.70332","type":"journal-article","created":{"date-parts":[[2024,11,5]],"date-time":"2024-11-05T08:39:43Z","timestamp":1730795983000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Disease Characteristics and Outcomes of 493 Young Myeloma Patients Treated With Modern Therapies: A Canadian Myeloma Research Group Database Study"],"prefix":"10.1002","volume":"13","author":[{"given":"M\u00e9gane","family":"Tanguay","sequence":"first","affiliation":[{"name":"Institut universitaire d'h\u00e9mato\u2010oncologie et de th\u00e9rapie cellulaire H\u00f4pital Maisonneuve\u2010Rosemont  Montr\u00e9al Qu\u00e9bec Canada"},{"name":"Universit\u00e9 de Montr\u00e9al  Montr\u00e9al Qu\u00e9bec Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jean","family":"Roy","sequence":"additional","affiliation":[{"name":"Institut universitaire d'h\u00e9mato\u2010oncologie et de 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