{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,30]],"date-time":"2025-07-30T08:06:27Z","timestamp":1753862787895,"version":"3.41.2"},"reference-count":28,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2024,2,24]],"date-time":"2024-02-24T00:00:00Z","timestamp":1708732800000},"content-version":"vor","delay-in-days":23,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cancer Medicine"],"published-print":{"date-parts":[[2024,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Introduction<\/jats:title><jats:p>Advances in multimodality cancer treatments have increased long\u2010term survival rates for early onset cancer patients, with 5\u2010year survival rates reaching 80% in Northern Europe. According to recent recommendations, clinicians should, as early as possible, inform cancer patients about the impact that cancer treatment may have on their fertility. Still, there is limited published data on fertility counselling (FC) and fertility preservation (FP) for cancer patients.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This register\u2010based study used hospital records to identify female cancer patients in the hospital district (<jats:italic>n<\/jats:italic>\u2009=\u2009192) who received FC at the age of 16\u201342\u2009years between 2011 and 2019.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Altogether, 97 (50.5%) cancer patients were eligible for FP. Of these, 55 (56.7%) underwent FP, whereas 42 (43.3%) declined. Women undergoing FP were recommended cancer treatments with a higher risk of infertility (<jats:italic>p<\/jats:italic>\u2009=\u20090.01), and women with breast cancer were more prone to undergo FP than women with lymphoma (<jats:italic>p<\/jats:italic>\u2009=\u20090.043). In FP treatment cycles, the mean number of oocytes retrieved (13.9\u2009\u00b1\u20097.7 vs. 12.0\u2009\u00b1\u20096.5, <jats:italic>p<\/jats:italic>\u2009=\u20090.04) and transferrable embryos (4.7\u2009\u00b1\u20092.9 vs. 3.7\u2009\u00b1\u20092.8, <jats:italic>p<\/jats:italic>\u2009=\u20090.002) was higher among cancer patients compared to age\u2010matched comparisons with male or tubal factor infertility. The total mean gonadotropin dose used was higher among cancer patients (2243\u2009\u00b1\u2009963\u2009IU vs. 1679\u2009\u00b1\u2009765\u2009IU, <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>We conclude that a good ovarian response during FP can be achieved in female cancer patients.<\/jats:p><\/jats:sec>","DOI":"10.1002\/cam4.7034","type":"journal-article","created":{"date-parts":[[2024,2,24]],"date-time":"2024-02-24T09:03:36Z","timestamp":1708765416000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Fertility counselling and fertility preservation among early onset female cancer patients\u2014A Finnish register\u2010based study"],"prefix":"10.1002","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3561-7097","authenticated-orcid":false,"given":"Johanna","family":"Melin","sequence":"first","affiliation":[{"name":"Department of Obstetrics and Gynecology University of Helsinki, Helsinki University Hospital  Helsinki Finland"},{"name":"Monash Centre for Health Research and Implementation School of public Health and Preventive Medicine Monash University  Melbourne Victoria Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elina","family":"Holopainen","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology University of Helsinki, Helsinki University Hospital  Helsinki Finland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hanna","family":"Savolainen\u2010Peltonen","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology University of Helsinki, Helsinki University Hospital  Helsinki Finland"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2024,2,24]]},"reference":[{"key":"e_1_2_12_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.28844"},{"key":"e_1_2_12_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1470-2045(16)00162-5"},{"key":"e_1_2_12_4_1","doi-asserted-by":"publisher","DOI":"10.3322\/caac.21637"},{"key":"e_1_2_12_5_1","doi-asserted-by":"publisher","DOI":"10.1093\/humrep\/dey216"},{"key":"e_1_2_12_6_1","article-title":"ESHRE guideline: female fertility preservation","volume":"4","author":"Anderson R","year":"2020","journal-title":"Hum Reprod 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