{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T18:53:08Z","timestamp":1790103188077,"version":"4.0.1"},"reference-count":39,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2024,3,13]],"date-time":"2024-03-13T00:00:00Z","timestamp":1710288000000},"content-version":"vor","delay-in-days":12,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cancer Medicine"],"published-print":{"date-parts":[[2024,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Salivary duct carcinoma (SDC) is a high\u2010grade adenocarcinoma with a 5\u2010year survival rate of 40%. Although drug therapy has improved patients' prognosis, the impact of brain metastasis (BM) remains poorly understood. We aimed to retrospectively examine the incidence of BM in patients with SDC (<jats:italic>n<\/jats:italic>\u2009=\u2009464) and develop a tool to estimate their prognoses.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We retrospectively examined 464 patients with SDC enrolled in a multicenter study. We investigated the incidence of BM, overall survival (OS) rates, and factors affecting prognosis in patients with BM. We also developed an SDC\u2010graded prognostic assessment (GPA) score for disease prognostication.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Sixty\u2010five (14%) patients had BM. The median OS (mOS) was 13.1\u2009months. On univariate and multivariate analyses, factors such as Eastern Cooperative Oncology Group Performance Status &gt;1, human epidermal growth factor receptor 2\u2010negative status, and locoregional uncontrolled disease were associated with poor OS. SDC\u2010GPA scores according to the prognostic factors were 0, 1, 2, and 3 points, and mOS estimates were 50.5, 16.1, 3.9, and 1.2\u2009months, respectively (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The SDC\u2010GPA score emerged as a useful prognostication tool for patients with BM.<\/jats:p><\/jats:sec>","DOI":"10.1002\/cam4.7037","type":"journal-article","created":{"date-parts":[[2024,3,13]],"date-time":"2024-03-13T12:14:02Z","timestamp":1710332042000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Brain metastases in patients with salivary duct carcinoma: A retrospective study"],"prefix":"10.1002","volume":"13","author":[{"given":"Chihiro","family":"Fushimi","sequence":"first","affiliation":[{"name":"Head and Neck Oncology and Surgery International University of Health and Welfare, Mita Hospital  Tokyo 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