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The aim of this study was to investigate the effect of xCT on the outcome of patients diagnosed with new head and neck squamous cell carcinoma (HNSCC).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      This retrospective cohort study utilized a population\u2010based dataset, comprising all patients (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u20091033) diagnosed with new HNSCC during 2005\u20132015 in a population of 697,000 people. All patients (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u2009585) with a tumor tissue sample available for immunohistochemical (IHC) staining were included. The follow\u2010up rates were 97% and 81% at 3 and 5\u2009years, respectively. Also, the specificity of the anti\u2010xCT antibody was validated.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      The expression level and prognostic significance of xCT were strongly dependent on tumor location. In oropharyngeal squamous cell carcinoma (OPSCC) patients, xCT expression was a significant prognostic factor for 5\u2010year overall survival (OAS) (HR: 2.71; 95% CI 1.67\u20134.39;\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001), disease\u2010specific survival (DSS) (HR: 2.58; 95% CI 1.47\u20134.54;\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.001), and disease\u2010free survival (DFS) (HR: 2.69; 95% CI 1.55\u20134.64;\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001). Five\u2010year survival rates for OPSCC patients with high and low levels of xCT were OAS 34% versus 62%; DSS 51% versus 73%; DFS 43% versus 73%, respectively. According to a multivariate model adjusted for age, T\u2010class, nodal positivity, and tobacco consumption, xCT was an independent prognostic factor for 3\u2010year survival, in which it outperformed p16 IHC. Similar associations were not observed in squamous cell carcinomas of oral cavity or larynx. Regarding treatment modalities, xCT was most predictive in HNSCC patients who received radiotherapy.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>High xCT expression was associated with poor prognosis in OPSCC. Our findings suggest that joint analysis of xCT and p16 may add significant value in OPSCC treatment stratification.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/cam4.70371","type":"journal-article","created":{"date-parts":[[2024,11,2]],"date-time":"2024-11-02T05:14:42Z","timestamp":1730524482000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["<scp>xCT<\/scp>\n                    as a Predictor for Survival in a Population\u2010Based Cohort of Head and Neck Squamous Cell Carcinoma"],"prefix":"10.1002","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6971-2274","authenticated-orcid":false,"given":"Linda","family":"Nissi","sequence":"first","affiliation":[{"name":"Department of Oncology, and FICAN West Cancer Centre Turku University Hospital and University of Turku  Turku 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