{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,9]],"date-time":"2025-12-09T13:00:52Z","timestamp":1765285252077,"version":"3.46.0"},"reference-count":29,"publisher":"Wiley","issue":"21","license":[{"start":{"date-parts":[[2024,11,2]],"date-time":"2024-11-02T00:00:00Z","timestamp":1730505600000},"content-version":"vor","delay-in-days":1,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["19K17233","23K06715"],"award-info":[{"award-number":["19K17233","23K06715"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cancer Medicine"],"published-print":{"date-parts":[[2024,11]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Functional outcomes after hypopharyngeal cancer (HPC) treatment have a significant effect on patients' quality of life and prognosis. This study aimed to identify the predictive factors associated with laryngo\u2010esophageal dysfunction in patients with HPC who received definitive radiotherapy.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Patients with HPC treated with definitive intensity\u2010modulated radiotherapy between 2007 and 2019 at our institution were retrospectively evaluated. Laryngo\u2010esophageal dysfunction\u2010free survival (LDFS) events were defined as local recurrence, laryngo\u2010esophageal dysfunction (defined as tracheostomy or feeding tube dependence), or death from any cause.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>The median follow\u2010up period was 61\u2009months for the 80 patients included in the study. The 5\u2010year LDFS rate was 47%. A clinical T4 stage and lower pretreatment prognostic nutritional index (PNI) were independently associated with a lower LDFS.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>A clinical T4 stage and lower pretreatment PNI were identified as predictors of a lower LDFS after definitive radiotherapy for HPC.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/cam4.70374","type":"journal-article","created":{"date-parts":[[2024,11,2]],"date-time":"2024-11-02T03:54:04Z","timestamp":1730519644000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Preserving Laryngo\u2010Esophageal Function in Patients With Hypopharyngeal Cancer Treated With Radiotherapy: Predictive Factors and Long\u2010Term Outcomes"],"prefix":"10.1002","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5942-4647","authenticated-orcid":false,"given":"Aya","family":"Nakajima","sequence":"first","affiliation":[{"name":"Department of Radiation Oncology and Image\u2010Applied Therapy, Graduate School of Medicine Kyoto University  Kyoto Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6665-2245","authenticated-orcid":false,"given":"Michio","family":"Yoshimura","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology and Image\u2010Applied Therapy, Graduate School of Medicine Kyoto University  Kyoto Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shinya","family":"Hiraoka","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology and Image\u2010Applied Therapy, Graduate School of Medicine Kyoto University  Kyoto Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ryota","family":"Nakashima","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology and Image\u2010Applied Therapy, Graduate School of Medicine Kyoto University  Kyoto Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yo","family":"Kishimoto","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology, Head and Neck Surgery, Graduate School of Medicine Kyoto University  Kyoto Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3404-5461","authenticated-orcid":false,"given":"Koichi","family":"Omori","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology, Head and Neck Surgery, Graduate School of Medicine Kyoto University  Kyoto Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8135-8746","authenticated-orcid":false,"given":"Takashi","family":"Mizowaki","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology and Image\u2010Applied Therapy, Graduate School of Medicine Kyoto University  Kyoto Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2024,11,2]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.3322\/caac.21660"},{"key":"e_1_2_11_3_1","unstructured":"Japan Society for Head and Neck Cancer \u201cReport of Head and Neck Cancer Registry of Japan Clinical Statistics of Registered Patients \u201d2020 http:\/\/www.jshnc.umin.ne.jp\/pdf\/HNCreport_2020.pdf."},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/cam4.4539"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/hed.24752"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.anl.2023.07.003"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1093\/jnci\/88.13.890"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.1093\/jnci\/djn460"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.1093\/annonc\/mds065"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijrobp.2011.03.040"},{"issue":"1","key":"e_1_2_11_11_1","first-page":"E2091","article-title":"Outcomes for Hypopharyngeal Carcinoma Treated With Organ\u2010Preservation Therapy","volume":"38","author":"Edson M. 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