{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,24]],"date-time":"2026-06-24T09:05:40Z","timestamp":1782291940975,"version":"3.54.5"},"reference-count":35,"publisher":"Wiley","issue":"21","license":[{"start":{"date-parts":[[2024,11,4]],"date-time":"2024-11-04T00:00:00Z","timestamp":1730678400000},"content-version":"vor","delay-in-days":3,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cancer Medicine"],"published-print":{"date-parts":[[2024,11]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>This study aimed to evaluate the prognostic value of the Mayo additive staging system (MASS) and minimal residual disease (MRD) in newly diagnosed multiple myeloma (NDMM) patients.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>A total of 238 NDMM patients were enrolled in Beijing Chaoyang Hospital. Fluorescence in\u2010situ hybridization and next\u2010generation flow cytometry were used to examine cytogenetic abnormalities and MRD, respectively. The patients were classified into three groups to compare the effects on progression\u2010free survival (PFS). Univariate and multivariate analyses were applied to identify the survival\u2010related factors.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      For MASS group, the PFS was significant difference in MASS I, II, and III patients (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.0006); the patients with sustained MRD\u2010negative, non\u2010sustained MRD\u2010negative, sustained MRD\u2010positive, and non\u2010sustained MRD\u2010positive were divided into Groups 1, 2, 3, and 4, respectively. The Group 1 patients had superior PFS than Groups 2 and 3 patients (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.05), but no difference in PFS was observed for Group 2 versus Group 3, Group 2 versus Group 4, and Group 3 versus Group 4 patients. For the MASS and MRD groups, among Groups 2, 3, and 4, MASS I patients had a superior PFS, while III patients showed the opposite result. Strikingly, no difference in PFS for Group 1 patients regardless of the MASS stage was observed. Despite being in MASS II and III, the PFS of Group 1 patients was longer than those with the other three groups. Response to treatment was an independent prognostic factor for MM patients.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Patients with an accumulation of high\u2010risk factors and MRD\u2010positive have poor outcomes. Sustained MRD\u2010negative may improve high\u2010risk patients' prognoses.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/cam4.70382","type":"journal-article","created":{"date-parts":[[2024,11,4]],"date-time":"2024-11-04T05:55:03Z","timestamp":1730699703000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Evaluation of the Prognostic Value of the Mayo Additive Staging System and Minimal Residual Disease in Newly Diagnosed Multiple Myeloma Patients"],"prefix":"10.1002","volume":"13","author":[{"given":"Yichuan","family":"Song","sequence":"first","affiliation":[{"name":"Department of Clinical Laboratory, Beijing Chao\u2010Yang Hospital Capital Medical University  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rui","family":"Zhao","sequence":"additional","affiliation":[{"name":"Department of Clinical Laboratory, Beijing Chao\u2010Yang Hospital Capital Medical University  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenxuan","family":"Fu","sequence":"additional","affiliation":[{"name":"Department of Clinical Laboratory, Beijing Chao\u2010Yang Hospital Capital Medical University  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jing","family":"Zhao","sequence":"additional","affiliation":[{"name":"Department of Clinical Laboratory, Beijing Chao\u2010Yang Hospital Capital Medical University  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qingtao","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Clinical Laboratory, Beijing Chao\u2010Yang Hospital Capital Medical University  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7258-8745","authenticated-orcid":false,"given":"Rui","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Clinical Laboratory, Beijing Chao\u2010Yang Hospital Capital Medical University  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,11,4]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2007-10-078022"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI61188"},{"issue":"8","key":"e_1_2_10_4_1","first-page":"1445","article-title":"Establishment of Multiple Myeloma Diagnostic Model Based on Logistic Regression in Clinical Laboratory","volume":"66","author":"Cui R.","year":"2020","journal-title":"Clinical Laboratory"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1080\/10428194.2021.1948032"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41408-022-00611-x"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41408-022-00731-4"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/ejh.13897"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1080\/16078454.2023.2208914"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1470-2045(16)30206-6"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.18632\/oncotarget.12641"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2010-10-299487"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2014-07-590166"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamaoncol.2016.3160"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2010-10-300970"},{"issue":"30","key":"e_1_2_10_16_1","first-page":"2345","article-title":"Prognostic Value of Minimal Residual Disease Status in Patients With Multiple Myeloma After Autologous Hematopoietic Stem Cell Transplantation in the Era of New Drugs","volume":"102","author":"Yang G. 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