{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T08:33:27Z","timestamp":1792139607784,"version":"4.4.0"},"reference-count":189,"publisher":"Wiley","issue":"21","license":[{"start":{"date-parts":[[2024,11,4]],"date-time":"2024-11-04T00:00:00Z","timestamp":1730678400000},"content-version":"vor","delay-in-days":3,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81974405"],"award-info":[{"award-number":["81974405"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82373332"],"award-info":[{"award-number":["82373332"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cancer Medicine"],"published-print":{"date-parts":[[2024,11]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>Macrophages are essential in maintaining homeostasis, combating infections, and influencing the process of various diseases, including cancer. Macrophages originate from diverse lineages: Notably, tissue\u2010resident macrophages (TRMs) differ from hematopoietic stem cells and circulating monocyte\u2010derived macrophages based on genetics, development, and function. Therefore, understanding the recruited and TRM populations is crucial for investigating disease processes.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>By searching literature databses, we summarized recent relevant studies. Research has shown that tumor\u2010associated macrophages (TAMs) of distinct origins accumulate in tumor microenvironment (TME), with TRM\u2010derived TAMs closely resembling gene signatures of normal TRMs.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Recent studies have revealed that TRMs play a crucial role in cancer progression. However, organ\u2010specific effects complicate TRM investigations. Nonetheless, the precise involvement of TRMs in tumors is unclear. This review explores the multifaceted roles of TRMs in cancer, presenting insights into their origins, proliferation, the latest research methodologies, their impact across various tumor sites, their potential and strategies as therapeutic targets, interactions with other cells within the TME, and the internal heterogeneity of TRMs.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>We believe that a comprehensive understanding of the multifaceted roles of TRMs will pave the way for targeted TRM therapies in the treatment of cancer.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/cam4.70387","type":"journal-article","created":{"date-parts":[[2024,11,4]],"date-time":"2024-11-04T07:39:11Z","timestamp":1730705951000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":14,"title":["Tissue\u2010Resident Macrophages in Cancer: Friend or Foe?"],"prefix":"10.1002","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3384-4918","authenticated-orcid":false,"given":"Jianhua","family":"Chi","sequence":"first","affiliation":[{"name":"Department of Obstetrics and Gynecology National Clinical Research Center for Obstetrics and Gynecology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology  Wuhan China"},{"name":"Key Laboratory of Cancer Invasion and Metastasis (Ministry of Education), Hubei Key Laboratory of Tumor Invasion and Metastasis Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology  Wuhan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9448-3423","authenticated-orcid":false,"given":"Qinglei","family":"Gao","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology National Clinical Research Center for Obstetrics and Gynecology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology  Wuhan China"},{"name":"Key Laboratory of Cancer Invasion and Metastasis (Ministry of Education), Hubei Key Laboratory of Tumor Invasion and Metastasis Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology  Wuhan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dan","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology National Clinical Research Center for Obstetrics and Gynecology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology  Wuhan China"},{"name":"Key Laboratory of Cancer Invasion and Metastasis (Ministry of Education), Hubei Key Laboratory of Tumor Invasion and Metastasis Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology  Wuhan China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,11,4]]},"reference":[{"key":"e_1_2_15_2_1","doi-asserted-by":"publisher","DOI":"10.3389\/fcell.2022.1068720"},{"key":"e_1_2_15_3_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.164.12.6166"},{"key":"e_1_2_15_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbcan.2009.02.004"},{"key":"e_1_2_15_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.it.2022.04.008"},{"key":"e_1_2_15_6_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41392-023-01452-1"},{"key":"e_1_2_15_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.drup.2023.101041"},{"key":"e_1_2_15_8_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood.2023020597"},{"key":"e_1_2_15_9_1","doi-asserted-by":"publisher","DOI":"10.1186\/s40164-023-00469-0"},{"key":"e_1_2_15_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.copbio.2023.102984"},{"key":"e_1_2_15_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2021.07.007"},{"key":"e_1_2_15_12_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-023-06002-x"},{"key":"e_1_2_15_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2019.08.009"},{"key":"e_1_2_15_14_1","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.34505"},{"key":"e_1_2_15_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2017.07.014"},{"key":"e_1_2_15_16_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41593-020-00789-y"},{"key":"e_1_2_15_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2019.03.009"},{"key":"e_1_2_15_18_1","doi-asserted-by":"publisher","DOI":"10.1002\/cam4.7053"},{"key":"e_1_2_15_19_1","doi-asserted-by":"publisher","DOI":"10.1038\/s42003-023-04525-7"},{"key":"e_1_2_15_20_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41590-022-01267-2"},{"key":"e_1_2_15_21_1","doi-asserted-by":"publisher","DOI":"10.3390\/cells10040960"},{"key":"e_1_2_15_22_1","doi-asserted-by":"publisher","DOI":"10.3390\/cells10040903"},{"key":"e_1_2_15_23_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature13989"},{"key":"e_1_2_15_24_1","doi-asserted-by":"publisher","DOI":"10.1172\/jci.insight.141115"},{"key":"e_1_2_15_25_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-022-35095-7"},{"key":"e_1_2_15_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2014.11.018"},{"key":"e_1_2_15_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2022.10.007"},{"key":"e_1_2_15_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.it.2024.02.007"},{"key":"e_1_2_15_29_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2018.02925"},{"key":"e_1_2_15_30_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-1-0716-0704-6_6"},{"key":"e_1_2_15_31_1","doi-asserted-by":"publisher","DOI":"10.1158\/2159-8290.CD-23-1300"},{"key":"e_1_2_15_32_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12967-024-05035-8"},{"key":"e_1_2_15_33_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms22010194"},{"key":"e_1_2_15_34_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2021.716504"},{"key":"e_1_2_15_35_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-1-0716-3437-0_18"},{"key":"e_1_2_15_36_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2022.903069"},{"key":"e_1_2_15_37_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2018.00697"},{"key":"e_1_2_15_38_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bcp.2019.113672"},{"key":"e_1_2_15_39_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms21134808"},{"key":"e_1_2_15_40_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.crmeth.2022.100260"},{"key":"e_1_2_15_41_1","doi-asserted-by":"publisher","DOI":"10.1042\/BST20221008"},{"key":"e_1_2_15_42_1","doi-asserted-by":"publisher","DOI":"10.1128\/microbiolspec.MCHD-0031-2016"},{"key":"e_1_2_15_43_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1194637"},{"key":"e_1_2_15_44_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2013.04.004"},{"key":"e_1_2_15_45_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1219179"},{"key":"e_1_2_15_46_1","doi-asserted-by":"publisher","DOI":"10.1038\/ncomms2877"},{"key":"e_1_2_15_47_1","doi-asserted-by":"publisher","DOI":"10.1038\/ni.2705"},{"key":"e_1_2_15_48_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2015.07.016"},{"key":"e_1_2_15_49_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2015.11.022"},{"key":"e_1_2_15_50_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2015.03.011"},{"key":"e_1_2_15_51_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2023.113364"},{"key":"e_1_2_15_52_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2020.05.014"},{"key":"e_1_2_15_53_1","doi-asserted-by":"publisher","DOI":"10.1038\/nri.2017.42"},{"key":"e_1_2_15_54_1","doi-asserted-by":"publisher","DOI":"10.1038\/ncomms11852"},{"key":"e_1_2_15_55_1","doi-asserted-by":"publisher","DOI":"10.1126\/sciimmunol.abf7777"},{"key":"e_1_2_15_56_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2018.04.018"},{"key":"e_1_2_15_57_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-018-02834-8"},{"issue":"11","key":"e_1_2_15_58_1","article-title":"Self\u2010Renewal of Macrophages: Tumor\u2010Released Factors and Signaling Pathways","volume":"10","author":"Filiberti S.","year":"2022","journal-title":"Biomedicine"},{"key":"e_1_2_15_59_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2020.10.021"},{"key":"e_1_2_15_60_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41582-018-0072-1"},{"key":"e_1_2_15_61_1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20160844"},{"key":"e_1_2_15_62_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2017.08.046"},{"key":"e_1_2_15_63_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2019.09.002"},{"key":"e_1_2_15_64_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-030-12734-3_7"},{"key":"e_1_2_15_65_1","doi-asserted-by":"publisher","DOI":"10.1227\/00006123-200004000-00035"},{"key":"e_1_2_15_66_1","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.29379"},{"key":"e_1_2_15_67_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI200522675"},{"key":"e_1_2_15_68_1","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-16-2310"},{"key":"e_1_2_15_69_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2019.02215"},{"key":"e_1_2_15_70_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2016.10.052"},{"key":"e_1_2_15_71_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.1100605"},{"key":"e_1_2_15_72_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ccell.2021.05.006"},{"key":"e_1_2_15_73_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2023.1104694"},{"key":"e_1_2_15_74_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-1-0716-3437-0_2"},{"key":"e_1_2_15_75_1","doi-asserted-by":"publisher","DOI":"10.3389\/fonc.2020.566511"},{"key":"e_1_2_15_76_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2020.08.040"},{"key":"e_1_2_15_77_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI25673"},{"key":"e_1_2_15_78_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2005.12.039"},{"key":"e_1_2_15_79_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0167-4781(01)00358-X"},{"key":"e_1_2_15_80_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V100.5.1742.h81702001742_1742_1754"},{"key":"e_1_2_15_81_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.imlet.2005.02.012"},{"key":"e_1_2_15_82_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.canlet.2022.215996"},{"key":"e_1_2_15_83_1","doi-asserted-by":"publisher","DOI":"10.1038\/labinvest.2014.73"},{"key":"e_1_2_15_84_1","doi-asserted-by":"publisher","DOI":"10.1615\/CritRevImmunol.v32.i6.10"},{"key":"e_1_2_15_85_1","doi-asserted-by":"publisher","DOI":"10.1111\/imm.12451"},{"key":"e_1_2_15_86_1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20180534"},{"key":"e_1_2_15_87_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-021-03651-8"},{"key":"e_1_2_15_88_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ccell.2023.05.006"},{"key":"e_1_2_15_89_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.1403215"},{"key":"e_1_2_15_90_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41388-022-02488-3"},{"key":"e_1_2_15_91_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.canlet.2022.215667"},{"key":"e_1_2_15_92_1","doi-asserted-by":"publisher","DOI":"10.1172\/jci.insight.160978"},{"key":"e_1_2_15_93_1","doi-asserted-by":"publisher","DOI":"10.4161\/cbt.24593"},{"key":"e_1_2_15_94_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-022-32080-y"},{"key":"e_1_2_15_95_1","doi-asserted-by":"publisher","DOI":"10.15252\/embj.2019103790"},{"key":"e_1_2_15_96_1","doi-asserted-by":"publisher","DOI":"10.1002\/jnr.23922"},{"key":"e_1_2_15_97_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2023.1263633"},{"key":"e_1_2_15_98_1","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.34468"},{"key":"e_1_2_15_99_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2023.112620"},{"key":"e_1_2_15_100_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2022.02.021"},{"key":"e_1_2_15_101_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2023.1180209"},{"key":"e_1_2_15_102_1","doi-asserted-by":"publisher","DOI":"10.1038\/s42003-020-01246-z"},{"key":"e_1_2_15_103_1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20191869"},{"key":"e_1_2_15_104_1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20210924"},{"key":"e_1_2_15_105_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2024.114096"},{"key":"e_1_2_15_106_1","doi-asserted-by":"publisher","DOI":"10.1172\/jci.insight.124164"},{"key":"e_1_2_15_107_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2022.961350"},{"key":"e_1_2_15_108_1","doi-asserted-by":"publisher","DOI":"10.1111\/cas.12212"},{"key":"e_1_2_15_109_1","doi-asserted-by":"publisher","DOI":"10.1158\/2159-8290.CD-RW2021-089"},{"key":"e_1_2_15_110_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2017.02.026"},{"key":"e_1_2_15_111_1","doi-asserted-by":"publisher","DOI":"10.3389\/fmolb.2023.1129831"},{"key":"e_1_2_15_112_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2019.02093"},{"key":"e_1_2_15_113_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2019.01941"},{"key":"e_1_2_15_114_1","doi-asserted-by":"publisher","DOI":"10.1186\/1742-2094-11-125"},{"key":"e_1_2_15_115_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.gene.2015.08.060"},{"issue":"6","key":"e_1_2_15_116_1","first-page":"1172","article-title":"VSIG4 Is Highly Expressed and Correlated With Poor Prognosis of High\u2010Grade Glioma Patients","volume":"7","author":"Xu T.","year":"2015","journal-title":"American Journal of Translational Research"},{"key":"e_1_2_15_117_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10120-020-01120-1"},{"key":"e_1_2_15_118_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41590-023-01579-x"},{"key":"e_1_2_15_119_1","doi-asserted-by":"publisher","DOI":"10.1158\/2159-8290.CD-RW2023-130"},{"key":"e_1_2_15_120_1","doi-asserted-by":"publisher","DOI":"10.1155\/2016\/4549676"},{"key":"e_1_2_15_121_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12094-020-02348-0"},{"key":"e_1_2_15_122_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.intimp.2022.109047"},{"key":"e_1_2_15_123_1","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.34364"},{"key":"e_1_2_15_124_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41556-020-0505-0"},{"key":"e_1_2_15_125_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-018-08065-1"},{"key":"e_1_2_15_126_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10911-021-09483-6"},{"key":"e_1_2_15_127_1","doi-asserted-by":"publisher","DOI":"10.1093\/biolre\/ioaa219"},{"key":"e_1_2_15_128_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrc.2016.54"},{"key":"e_1_2_15_129_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.coph.2015.09.007"},{"key":"e_1_2_15_130_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41590-023-01428-x"},{"key":"e_1_2_15_131_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1617903113"},{"key":"e_1_2_15_132_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.510230542"},{"key":"e_1_2_15_133_1","doi-asserted-by":"publisher","DOI":"10.3892\/ijmm.2016.2561"},{"key":"e_1_2_15_134_1","doi-asserted-by":"publisher","DOI":"10.1111\/imm.12251"},{"key":"e_1_2_15_135_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbi.2019.10.009"},{"key":"e_1_2_15_136_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cellimm.2017.09.006"},{"key":"e_1_2_15_137_1","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-20-2990"},{"key":"e_1_2_15_138_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12026-022-09330-8"},{"key":"e_1_2_15_139_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejmech.2022.114884"},{"key":"e_1_2_15_140_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13045-022-01335-y"},{"key":"e_1_2_15_141_1","doi-asserted-by":"publisher","DOI":"10.3390\/cells7080103"},{"key":"e_1_2_15_142_1","doi-asserted-by":"publisher","DOI":"10.1136\/gutjnl-2021-324339"},{"key":"e_1_2_15_143_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI157937"},{"key":"e_1_2_15_144_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2020.07.013"},{"key":"e_1_2_15_145_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2020.06.032"},{"key":"e_1_2_15_146_1","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-09-2050"},{"key":"e_1_2_15_147_1","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-20-1414"},{"key":"e_1_2_15_148_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pharmthera.2021.108031"},{"key":"e_1_2_15_149_1","doi-asserted-by":"publisher","DOI":"10.1189\/jlb.3HI1214-584R"},{"issue":"3","key":"e_1_2_15_150_1","doi-asserted-by":"crossref","DOI":"10.1136\/jitc-2022-006433","article-title":"Invasive Margin Tissue\u2010Resident Macrophages of High CD163 Expression Impede Responses to T Cell\u2010Based Immunotherapy","volume":"11","author":"Elsas M. J.","year":"2023","journal-title":"Journal for Immunotherapy of Cancer"},{"key":"e_1_2_15_151_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0093650"},{"key":"e_1_2_15_152_1","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-09-2995"},{"key":"e_1_2_15_153_1","doi-asserted-by":"publisher","DOI":"10.18632\/oncotarget.1201"},{"key":"e_1_2_15_154_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41590-020-00849-2"},{"key":"e_1_2_15_155_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.2210836120"},{"key":"e_1_2_15_156_1","doi-asserted-by":"publisher","DOI":"10.1038\/nm.3337"},{"key":"e_1_2_15_157_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1525360113"},{"key":"e_1_2_15_158_1","doi-asserted-by":"publisher","DOI":"10.1126\/sciadv.adk9878"},{"key":"e_1_2_15_159_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2020.02.015"},{"key":"e_1_2_15_160_1","doi-asserted-by":"publisher","DOI":"10.32471\/exp-oncology.2312-8852.vol-42-no-3.14928"},{"key":"e_1_2_15_161_1","doi-asserted-by":"publisher","DOI":"10.3389\/fcell.2022.803563"},{"key":"e_1_2_15_162_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12885-023-10675-y"},{"key":"e_1_2_15_163_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41590-023-01634-7"},{"key":"e_1_2_15_164_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2015.04.010"},{"key":"e_1_2_15_165_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2020.09.064"},{"key":"e_1_2_15_166_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41590-024-01819-8"},{"key":"e_1_2_15_167_1","doi-asserted-by":"publisher","DOI":"10.7554\/eLife.29540"},{"key":"e_1_2_15_168_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2010.12.011"},{"key":"e_1_2_15_169_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2018.02472"},{"key":"e_1_2_15_170_1","doi-asserted-by":"publisher","DOI":"10.1111\/cas.13565"},{"key":"e_1_2_15_171_1","doi-asserted-by":"publisher","DOI":"10.1158\/2326-6066.CIR-22-0271"},{"key":"e_1_2_15_172_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-017-08264-8"},{"key":"e_1_2_15_173_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41419-022-04605-2"},{"key":"e_1_2_15_174_1","doi-asserted-by":"publisher","DOI":"10.7150\/thno.60540"},{"key":"e_1_2_15_175_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41419-023-06021-6"},{"key":"e_1_2_15_176_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.drup.2024.101080"},{"key":"e_1_2_15_177_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41568-022-00497-8"},{"key":"e_1_2_15_178_1","doi-asserted-by":"publisher","DOI":"10.1038\/ni.3320"},{"key":"e_1_2_15_179_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-1-4939-7837-3_9"},{"key":"e_1_2_15_180_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2023.112732"},{"key":"e_1_2_15_181_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12864-017-3630-9"},{"key":"e_1_2_15_182_1","doi-asserted-by":"publisher","DOI":"10.1172\/jci.insight.86914"},{"key":"e_1_2_15_183_1","doi-asserted-by":"publisher","DOI":"10.1126\/sciimmunol.aax8756"},{"key":"e_1_2_15_184_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.aau0964"},{"key":"e_1_2_15_185_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.it.2021.04.007"},{"key":"e_1_2_15_186_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41422-020-0355-0"},{"key":"e_1_2_15_187_1","doi-asserted-by":"publisher","DOI":"10.1038\/cmi.2016.3"},{"key":"e_1_2_15_188_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-018-06318-7"},{"key":"e_1_2_15_189_1","doi-asserted-by":"publisher","DOI":"10.1182\/bloodadvances.2021005327"},{"key":"e_1_2_15_190_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.trecan.2022.02.006"}],"container-title":["Cancer Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/cam4.70387","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,12,9]],"date-time":"2025-12-09T12:55:23Z","timestamp":1765284923000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/cam4.70387"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,11]]},"references-count":189,"journal-issue":{"issue":"21","published-print":{"date-parts":[[2024,11]]}},"alternative-id":["10.1002\/cam4.70387"],"URL":"https:\/\/doi.org\/10.1002\/cam4.70387","archive":["Portico"],"relation":{},"ISSN":["2045-7634","2045-7634"],"issn-type":[{"value":"2045-7634","type":"print"},{"value":"2045-7634","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,11]]},"assertion":[{"value":"2024-07-18","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-10-20","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-11-04","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e70387"}}