{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,19]],"date-time":"2026-10-19T16:05:48Z","timestamp":1792425948578,"version":"4.5.0"},"reference-count":59,"publisher":"Wiley","issue":"21","license":[{"start":{"date-parts":[[2024,11,11]],"date-time":"2024-11-11T00:00:00Z","timestamp":1731283200000},"content-version":"vor","delay-in-days":10,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100004086","name":"College of Medicine, Koisin University","doi-asserted-by":"publisher","award":["2024"],"award-info":[{"award-number":["2024"]}],"id":[{"id":"10.13039\/501100004086","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cancer Medicine"],"published-print":{"date-parts":[[2024,11]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Antibody\u2010drug conjugates (ADC) have emerged as a highly promising systemic option in the treatment of recurrent ovarian cancer. The present study aimed to evaluate the treatment efficacy of folate receptor \u03b1 (FR\u03b1)\u2010targeting ADCs, associated treatment\u2010related adverse events (TRAEs), and their impact on treatment safety.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We conducted an electronic search to identify prospective trials of single\u2010agent ADCs targeting FR\u03b1 and those combined with chemotherapy in recurrent ovarian cancer. Information regarding the objective response rate (ORR) and TRAEs was collectively analyzed, and differences in subgroups based on FR\u03b1 receptor expression levels were investigated. The protocol was registered with PROSPERO (CRD42023491151).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Ten studies with a total of 940 patients (859 treated with Mirvetuximab soravtansine\u2010gynx (MIRV)), 45 with Farletuzumab Ecteribulin (MORAb\u2010202), and 36 with Luveltamab Tazevibulin (STRO\u2010002) were included in this meta\u2010analysis. Based on the pooled data, the ORR of the entire cohort was 37% (95% CI: 0.30\u20130.43), while that of the high\u2010FR\u03b1 expression group was 34% (95% CI: 0.26\u20130.42). The incidence of grade \u2265\u20093 adverse events was 27% (95% CI: 0.19\u20130.36).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>FR\u03b1\u2010targeting ADCs, including MIRV, demonstrated definite efficacy and good safety as novel choices for second\u2010line and beyond treatment of advanced or recurrent ovarian cancer. Patients with high FR\u03b1 expression showed ORR and PFS benefits similar to those in the overall cohort.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/cam4.70392","type":"journal-article","created":{"date-parts":[[2024,11,11]],"date-time":"2024-11-11T06:26:12Z","timestamp":1731306372000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":14,"title":["The Efficacy and Safety of Folate Receptor \u03b1\u2010Targeted Antibody\u2010Drug Conjugate Therapy in Patients With High\u2010Grade Epithelial Ovarian, Primary Peritoneal, or Fallopian Tube Cancers: A Systematic Review and Meta\u2010Analysis"],"prefix":"10.1002","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2754-2657","authenticated-orcid":false,"given":"Eun Taeg","family":"Kim","sequence":"first","affiliation":[{"name":"Department of Obstetrics and Gynecology Kosin University College of Medicine  Pusan Republic of 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