{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,9]],"date-time":"2025-12-09T12:57:48Z","timestamp":1765285068859,"version":"3.46.0"},"reference-count":27,"publisher":"Wiley","issue":"21","license":[{"start":{"date-parts":[[2024,11,8]],"date-time":"2024-11-08T00:00:00Z","timestamp":1731024000000},"content-version":"vor","delay-in-days":7,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cancer Medicine"],"published-print":{"date-parts":[[2024,11]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>There is a paucity of research on the effects of commonly used substances, such as cannabis and other drugs, on quality of life as a contributor to head and neck cancer (HNC) prognosis. We examined associations between non\u2010alcohol or tobacco substance use (cannabis and other illicit drug) and self\u2010reported quality of life in patients with HNC prior to starting treatment.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This was a cross\u2010sectional study of patients who presented for routine psych\u2010oncologevaluation prior to treatment between 11\/2015 and 9\/2022. Primary exposures were cannabis use (never, past, or current users) and current illicit drug use (yes\/no). The primary outcome measure was the Functional Assessment of Cancer Therapy\u2014Head and Neck (FACT\u2010HN) subscales (physical, social\/family, functional and emotional). Linear regression models examined associations between pretreatment substance use and FACT\u2010HN subscales adjusting for demographic, socioeconomic, and clinical factors.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Of 570 patients, 13.9% endorsed current cannabis and 13.9% current illicit drug use. The mean (SD) scores for FACT\u2010HN subscales were physical well\u2010being\u2009=\u200922.8 (5.0), social well\u2010being\u2009=\u200922.7 (5.5), emotional well\u2010being\u2009=\u200917.5 (4.5), and functional well\u2010being\u2009=\u200918.7 (6.9). In the adjusted models, cannabis use was not independently associated with any FACT\u2010HN subscales. However, patients who currently used illicit drugs reported worse emotional well\u2010being (\n                      <jats:italic>\u03b2<\/jats:italic>\n                      \u2009=\u2009\u22121.32; 95% CI \u22122.45 to \u22120.20). No independent association was found between current illicit drug use and other subscales (physical, social, and functional).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Illicit drug use, but not cannabis use, is negatively associated with pretreatment emotional well\u2010being in patients with HNC. Further research exploring the relationships between longitudinal cannabis and illicit drug use and methods of consumption on QoL and cancer outcomes in patients with head and neck cancer is warranted.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/cam4.70399","type":"journal-article","created":{"date-parts":[[2024,11,8]],"date-time":"2024-11-08T03:40:21Z","timestamp":1731037221000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Pretreatment Quality of Life and Substance Use Among Patients Diagnosed With Head and Neck Cancer"],"prefix":"10.1002","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9163-8103","authenticated-orcid":false,"given":"Eric","family":"Adjei Boakye","sequence":"first","affiliation":[{"name":"Department of Epidemiology and Biostatistics Michigan State University College of Human Medicine  East Lansing Michigan USA"},{"name":"Department of Otolaryngology\u2014Head &amp; Neck Surgery Henry Ford Health System  Detroit Michigan USA"},{"name":"Department of Public Health Sciences Henry Ford Health System  Detroit Michigan USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sami I.","family":"Nassar","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2014Head and Neck Surgery Medical University of South Carolina  Charleston South Carolina USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Suma J.","family":"Alzouhayli","sequence":"additional","affiliation":[{"name":"Department of Surgery Wayne State University School of Medicine  Detroit Michigan USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Amy M.","family":"Williams","sequence":"additional","affiliation":[{"name":"Office of Physician Wellness Henry Ford Health System  Detroit Michigan USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Steven S.","family":"Chang","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2014Head &amp; Neck Surgery Henry Ford Health System  Detroit Michigan USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tamer A.","family":"Ghanem","sequence":"additional","affiliation":[{"name":"Premier Head and Neck Surgery PC  Flint Michigan USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marissa","family":"Gilbert","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology Henry Ford Health System  Detroit Michigan USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Suhael","family":"Momin","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2014Head &amp; Neck Surgery Henry Ford Health System  Detroit Michigan USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Farzan","family":"Siddiqui","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology Henry Ford Health System  Detroit Michigan USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vivian F.","family":"Wu","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2014Head &amp; Neck Surgery Henry Ford Health System  Detroit Michigan USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Samantha H.","family":"Tam","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2014Head &amp; Neck Surgery Henry Ford Health System  Detroit Michigan USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2024,11,8]]},"reference":[{"key":"e_1_2_12_2_1","doi-asserted-by":"publisher","DOI":"10.4103\/jcrt.JCRT_311_18"},{"issue":"6","key":"e_1_2_12_3_1","first-page":"397","article-title":"A Review of Depression in the Head and Neck Cancer Patient","volume":"7","author":"Lydiatt W. 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