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The impact of <jats:italic><jats:styled-content style=\"fixed-case\">Fusobacterium nucleatum<\/jats:styled-content> (Fn<\/jats:italic>), a microbial risk factor for colorectal cancer (CRC), on the development of cachexia in CRC has not been established.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We evaluated the association between <jats:italic>Fn<\/jats:italic> abundance in pre\u2010surgical stool samples and onset of cachexia at 6\u2009months post\u2010surgery in <jats:italic>n<\/jats:italic>\u2009=\u200987 patients with stages I\u2013III CRC in the ColoCare Study.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>High fecal <jats:italic>Fn<\/jats:italic> abundance compared to negative\/low fecal <jats:italic>Fn<\/jats:italic> abundance was associated with 4\u2010fold increased risk of cachexia onset at 6\u2009months post\u2010surgery (OR\u2009=\u20094.82, 95% CI\u2009=\u20091.15, 20.10, <jats:italic>p<\/jats:italic>\u2009=\u20090.03).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Our findings suggest that high fecal <jats:italic>Fn<\/jats:italic> abundance was associated with an increased risk of cachexia at 6\u2009months post\u2010surgery in CRC patients. This is the first study to link <jats:italic>Fn<\/jats:italic> abundance with cachexia in CRC patients, offering novel insights into biological mechanisms and potential management of cancer cachexia. Due to the small sample size, our results should be interpreted with caution. Future studies with larger sample sizes are needed to validate these findings.<\/jats:p><\/jats:sec>","DOI":"10.1002\/cam4.70431","type":"journal-article","created":{"date-parts":[[2024,11,26]],"date-time":"2024-11-26T06:39:17Z","timestamp":1732603157000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["<scp><i>Fusobacterium nucleatum<\/i><\/scp> Abundance is Associated with Cachexia in Colorectal Cancer Patients: The <scp>ColoCare<\/scp> Study"],"prefix":"10.1002","volume":"13","author":[{"given":"Mmadili N.","family":"Ilozumba","sequence":"first","affiliation":[{"name":"Huntsman Cancer Institute  Salt Lake City Utah USA"},{"name":"Department of Population Sciences University of Utah  USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tengda","family":"Lin","sequence":"additional","affiliation":[{"name":"Huntsman Cancer Institute  Salt Lake City Utah USA"},{"name":"Department of Population Sciences University of Utah  USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0292-6168","authenticated-orcid":false,"given":"Sheetal","family":"Hardikar","sequence":"additional","affiliation":[{"name":"Huntsman Cancer Institute  Salt Lake City Utah USA"},{"name":"Department of Population Sciences University of Utah  USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Doratha A.","family":"Byrd","sequence":"additional","affiliation":[{"name":"H. 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