{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,17]],"date-time":"2026-09-17T05:45:56Z","timestamp":1789623956558,"version":"build-2803163510"},"reference-count":55,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2025,4,15]],"date-time":"2025-04-15T00:00:00Z","timestamp":1744675200000},"content-version":"vor","delay-in-days":14,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R01 CA244326"],"award-info":[{"award-number":["R01 CA244326"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cancer Medicine"],"published-print":{"date-parts":[[2025,4]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>Rural\u2013urban disparities in cancer care are well documented. However, research on rural\u2013urban disparities regarding patient\u2010reported outcomes (PROs) is still developing. This study analyzed rural\u2013urban disparities in patients with cancer with respect to anxiety, depression, fatigue, pain interference, and physical function.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This study was conducted at the University of Utah Huntsman Cancer Institute. We integrated data from electronic health records, Cancer Registry, and PRO questionnaires. We assessed the association between rurality status (rural vs. urban) in patients with cancer and PRO scores using multiple linear regression models and t\u2010tests.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      The cohort included 7271 patients. The mean age was 59.1\u2009years at cancer diagnosis and 48.2% (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u20093505) were female. Across all cancer types, significant differences (Rural vs. Urban) were found for fatigue (53.6 vs. 54.1;\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.05) and physical function (45.5 vs. 45.1;\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.05). With respect to specific cancer types, there were differences in patients with\n                      <jats:italic>oral cavity and pharynx cancer<\/jats:italic>\n                      for depression (47.9 vs. 50.6;\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.01), fatigue (51.6 vs. 54.8;\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.05), pain interference (52.8 vs. 55.4;\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.05), and physical function (48.0 vs. 44.6;\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.01),\n                      <jats:italic>colorectal cancer<\/jats:italic>\n                      for fatigue (56.8 vs. 54.7;\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.05), pain interference (56.0 vs. 53.7;\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.05), and physical function (42.2 vs. 44.4;\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.05),\n                      <jats:italic>uterus cancer<\/jats:italic>\n                      for depression (47.5 vs. 50.5;\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.05) and fatigue (51.6 vs. 54.7;\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.05), and\n                      <jats:italic>lung cancer<\/jats:italic>\n                      for physical function (37.6 vs. 39.3;\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.05).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Across all cancer types, as well as specific cancers, this study found mostly limited rural\u2013urban differences regarding PROs. Except for colorectal and lung\/bronchus cancer, patients living in rural areas reported similar or better PRO scores for all cancer types. Results support the hypothesis that improving access can help to level rural\u2013urban disparities regarding cancer care outcomes, because all patients were treated in the same comprehensive cancer center, had similar access to care, and had similar PRO scores.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/cam4.70437","type":"journal-article","created":{"date-parts":[[2025,4,15]],"date-time":"2025-04-15T06:28:46Z","timestamp":1744698526000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Rural\u2013Urban Disparities in Cancer Care\u2014Analyzing Routinely Collected Patient\u2010Reported Outcomes. A Cross\u2010Sectional Study"],"prefix":"10.1002","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5079-2152","authenticated-orcid":false,"given":"Dominik J.","family":"Ose","sequence":"first","affiliation":[{"name":"Department of Family and Preventive Medicine School of Medicine, University of Utah  Salt Lake City Utah USA"},{"name":"Faculty of Health and Healthcare Sciences Wests\u00e4chsische Hochschule Zwickau  Zwickau Saxony Germany"},{"name":"Huntsman Cancer Institute, University of Utah  Salt Lake City Utah USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bayarmaa","family":"Mark","sequence":"additional","affiliation":[{"name":"Huntsman Cancer Institute, University of Utah  Salt Lake City Utah USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Krista","family":"Ocier","sequence":"additional","affiliation":[{"name":"Huntsman Cancer Institute, University of Utah  Salt Lake City Utah 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