{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,8]],"date-time":"2026-05-08T17:08:07Z","timestamp":1778260087218,"version":"3.51.4"},"reference-count":47,"publisher":"Wiley","issue":"23","license":[{"start":{"date-parts":[[2024,12,11]],"date-time":"2024-12-11T00:00:00Z","timestamp":1733875200000},"content-version":"vor","delay-in-days":10,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100003819","name":"Natural Science Foundation of Hubei Province","doi-asserted-by":"publisher","award":["2019CFC929"],"award-info":[{"award-number":["2019CFC929"]}],"id":[{"id":"10.13039\/501100003819","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cancer Medicine"],"published-print":{"date-parts":[[2024,12]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:title>Objectives<\/jats:title><jats:p>Extensive\u2010stage small cell lung cancer (ES\u2010SCLC) suffering from brain metastases (BM) has a poor prognosis and lacks effective treatment selection. In this study, we explored the efficacy and safety of combination treatment of albumin\u2010bound paclitaxel (nab\u2010ptx), anlotinib, and PD\u20101\/L1 inhibitors for such special population.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A total of 55 patients diagnosed with ES\u2010SCLC and BM were enrolled in this retrospective study. Patients received a combination therapy consisting of nab\u2010ptx, anlotinib, and PD\u20101\/L1 inhibitors. The primary endpoints included overall response rate (ORR), progression\u2010free survival (PFS), overall survival (OS), and adverse events (AEs).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The results demonstrated promising efficacy of the combination therapy for such patients, with an ORR of 36.36%, median PFS and OS of 5.0 and 10.0\u2009m, correspondingly. Subgroup analyses indicated that treatment efficacy closely correlated with patients' Ds\u2010GPA (Diagnosis\u2010specified Graded Prognosis Assessment) scores. Mechanistic studies revealed that this regimen likely operates by reducing immune suppression to activate immune function, thereby exerting synergistic anti\u2010tumor effects. The common AEs include decreased appetite, nausea, leukopenia, hypertension, proteinuria, hand\u2010foot syndrome, peripheral neuropathy, rash, and thyroid toxicity, most of which are generally mild and can be alleviated with symptomatic treatment.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The combination of nab\u2010ptx, anlotinib, and PD\u20101\/L1 inhibitors exhibited substantial efficacy and acceptable safety in the treatment of BM from ES\u2010SCLC. This novel therapeutic approach holds promise for improving the outcomes for patients with this challenging disease. Further studies are needed to validate these findings and investigate the long\u2010term benefits of this combination regimen.<\/jats:p><\/jats:sec>","DOI":"10.1002\/cam4.70449","type":"journal-article","created":{"date-parts":[[2024,12,11]],"date-time":"2024-12-11T17:11:01Z","timestamp":1733937061000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["The Efficacy and Safety of Albumin\u2010Bound Paclitaxel Combined With Anlotinib and <scp>PD<\/scp>\u20101\/<scp>L1<\/scp> Inhibitors For Treating Patients With Extensive\u2010Stage Small Cell Lung Cancer and Brain Metastasis: A Retrospective Cohort Study"],"prefix":"10.1002","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3332-0575","authenticated-orcid":false,"given":"Xiaobing","family":"Li","sequence":"first","affiliation":[{"name":"Department of Thoracic Oncology, Hubei Cancer Hospital, Tongji Medical College Huazhong University of Science and Technology  Wuhan China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"De","family":"Wu","sequence":"additional","affiliation":[{"name":"Department of Pathology, Hubei Cancer Hospital, Tongji Medical College Huazhong University of Science and Technology  Wuhan China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yi","family":"Peng","sequence":"additional","affiliation":[{"name":"Department of Radiotherapy, Hubei Cancer Hospital, Tongji Medical College Huazhong University of Science and Technology  Wuhan China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jing","family":"Tang","sequence":"additional","affiliation":[{"name":"Department of Lymphoma, Hubei Cancer Hospital, Tongji Medical College Huazhong University of Science and Technology  Wuhan China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuebing","family":"Wu","sequence":"additional","affiliation":[{"name":"Department of Lymphoma, Hubei Cancer Hospital, 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