{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T14:35:31Z","timestamp":1786977331608,"version":"build-2736575974"},"reference-count":55,"publisher":"Wiley","issue":"23","license":[{"start":{"date-parts":[[2024,12,3]],"date-time":"2024-12-03T00:00:00Z","timestamp":1733184000000},"content-version":"vor","delay-in-days":2,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cancer Medicine"],"published-print":{"date-parts":[[2024,12]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Recruitment of cancer patients into clinical trials (CTs) is a challenge. We aimed to explore how patient eligibility assessment is conducted in practice, what factors support or hinder this process, and to assess the potential usefulness of Clinical Trial Recruitment Support Systems (CTRSS) for patient\u2010to\u2010trial matching.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We conducted semi\u2010structured interviews in France with healthcare professionals involved in cancer CTs and experts on trial recruitment. We focused on the stages in\u2010between trial feasibility, and patient information and consent. Interviews were recorded, and the transcripts were analyzed thematically. We used the Systems Engineering Initiative for Patient Safety (SEIPS) 2.0 framework to organize our results.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>We interviewed 25 participants. We identified common steps for cancer patient eligibility assessment: prescreening under medical supervision, followed by the validation of patient\u2010trial matching based on manual chart review. This process built on rich interactions between clinicians, other professionals (clinical research assistants, data scientists, medical coding experts), and patients. Technological factors, mainly related to data infrastructure (both for patient data and trial data), and organizational factors (research culture, incentives, formal and informal research networks) mediated the performance of the recruitment process. Participants had mixed feelings towards CTRSSs; they welcomed automated pre\u2010screening but insisted on manual verification. Given the necessary collaborative nature of multisite trials, coordinated efforts to support a common data infrastructure could be helpful.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Material, organizational, and human factors affect cancer patient eligibility assessment for CTs. Patient\u2010to\u2010trial matching tools bear potential, but good understanding of the ecosystem, including stakeholders' motivations, is a prerequisite.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/cam4.70466","type":"journal-article","created":{"date-parts":[[2024,12,3]],"date-time":"2024-12-03T05:39:47Z","timestamp":1733204387000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["\u201cThe Truth Is, We Must Miss Some\u201d: A Qualitative Study of the Patient Eligibility Screening Process, and Automation Perspectives, for Cancer Clinical Trials"],"prefix":"10.1002","volume":"13","author":[{"given":"A.","family":"La Rosa","sequence":"first","affiliation":[{"name":"Laboratoire d'Informatique M\u00e9dicale et d'Ing\u00e9nierie des Connaissances Pour la e\u2010Sant\u00e9, LIMICS Sorbonne University, Inserm, Universit\u00e9 Sorbonne Paris Nord  Paris Cedex France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Vaterkowski","sequence":"additional","affiliation":[{"name":"Laboratoire d'Informatique M\u00e9dicale et d'Ing\u00e9nierie des Connaissances Pour la e\u2010Sant\u00e9, LIMICS Sorbonne University, Inserm, Universit\u00e9 Sorbonne Paris Nord  Paris Cedex France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Cuggia","sequence":"additional","affiliation":[{"name":"LTSI\u2010UMR 1099 Universit\u00e9 de Rennes, CHU de Rennes  Rennes France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"B.","family":"Campillo\u2010Gimenez","sequence":"additional","affiliation":[{"name":"LTSI\u2010UMR 1099 Universit\u00e9 de Rennes, CLCC Eug\u00e8ne Marquis  Rennes France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C.","family":"Tournigand","sequence":"additional","affiliation":[{"name":"Department of Medical Oncology, Henri Mondor and Albert Chenevier Teaching Hospital Universit\u00e9 Paris Est Cr\u00e9teil, Assistance Publique\u2014H\u00f4pitaux de Paris  Creteil France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"B.","family":"Baujat","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology\u2010Head and Neck Surgery Sorbonne University, Assistance Publique\u2014H\u00f4pitaux de Paris, Tenon Hospital  Paris Cedex France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C.","family":"Daniel","sequence":"additional","affiliation":[{"name":"Laboratoire d'Informatique M\u00e9dicale et d'Ing\u00e9nierie des Connaissances Pour la e\u2010Sant\u00e9, LIMICS Sorbonne University, Inserm, Universit\u00e9 Sorbonne Paris Nord  Paris Cedex France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9285-1966","authenticated-orcid":false,"given":"E.","family":"Kempf","sequence":"additional","affiliation":[{"name":"Laboratoire d'Informatique M\u00e9dicale et d'Ing\u00e9nierie des Connaissances Pour la e\u2010Sant\u00e9, LIMICS Sorbonne University, Inserm, Universit\u00e9 Sorbonne Paris Nord  Paris Cedex France"},{"name":"Department of Medical Oncology, Henri Mondor and Albert Chenevier Teaching Hospital Universit\u00e9 Paris Est Cr\u00e9teil, Assistance Publique\u2014H\u00f4pitaux de Paris  Creteil France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9514-1890","authenticated-orcid":false,"given":"G.","family":"Lam\u00e9","sequence":"additional","affiliation":[{"name":"Laboratoire de G\u00e9nie Industriel, CentraleSup\u00e9lec\u2014Paris\u2010Saclay Campus  Gif Sur Yvette France"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,12,3]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1200\/JOP.2012.000598"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1093\/jnci\/djv324"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1093\/jnci\/dju229"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2003.02.105"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1200\/JOP.2012.000646"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1097\/PEC.0000000000001592"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.2196\/14185"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jclinepi.2016.07.016"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1080\/00365590801950253"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.conctc.2018.08.001"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00405-013-2349-8"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1470-2045(06)70576-9"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1186\/1745-6215-15-323"},{"key":"e_1_2_9_15_1","first-page":"123","article-title":"Prescreening in Oncology Using Data Sciences: The PreScIOUS Study","volume":"281","author":"Ansoborlo M.","year":"2021","journal-title":"Studies in Health Technology and Informatics"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1200\/CCI.19.00079"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1007\/s43441-019-00030-4"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00268-013-2283-3"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.1200\/CCI.19.00134"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10549-016-3850-8"},{"key":"e_1_2_9_21_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12885-020-07546-1"},{"key":"e_1_2_9_22_1","doi-asserted-by":"publisher","DOI":"10.1093\/jamia\/ocab228"},{"key":"e_1_2_9_23_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12874-024-02177-7"},{"key":"e_1_2_9_24_1","first-page":"1004","article-title":"Using an Information Warehouse to Screen Patients for Clinical Trials: A Prototype","volume":"2005","author":"Kamal J.","year":"2005","journal-title":"American Medical Informatics Association Annual Symposium Proceedings"},{"key":"e_1_2_9_25_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmjhci-2019-100008"},{"key":"e_1_2_9_26_1","first-page":"534","article-title":"Recruit\u2014An Ontology Based Information Retrieval System for Clinical Trials Recruitment","volume":"216","author":"Patr\u00e3o D. F.","year":"2015","journal-title":"Studies in Health Technology and Informatics"},{"key":"e_1_2_9_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ygyno.2015.05.008"},{"key":"e_1_2_9_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jbi.2022.104014"},{"key":"e_1_2_9_29_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmjopen-2011-000496"},{"key":"e_1_2_9_30_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13063-016-1341-1"},{"key":"e_1_2_9_31_1","doi-asserted-by":"publisher","DOI":"10.2196\/15749"},{"key":"e_1_2_9_32_1","doi-asserted-by":"publisher","DOI":"10.2196\/28696"},{"key":"e_1_2_9_33_1","doi-asserted-by":"publisher","DOI":"10.1002\/1098-240X(200008)23:4<334::AID-NUR9>3.0.CO;2-G"},{"key":"e_1_2_9_34_1","doi-asserted-by":"publisher","DOI":"10.1177\/1049732305276687"},{"key":"e_1_2_9_35_1","doi-asserted-by":"publisher","DOI":"10.1080\/00140139.2013.838643"},{"key":"e_1_2_9_36_1","doi-asserted-by":"publisher","DOI":"10.1097\/ACM.0000000000000388"},{"key":"e_1_2_9_37_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13063-016-1718-1"},{"key":"e_1_2_9_38_1","doi-asserted-by":"publisher","DOI":"10.1111\/jep.12678"},{"key":"e_1_2_9_39_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00392-016-1025-6"},{"key":"e_1_2_9_40_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmjopen-2021-051187"},{"key":"e_1_2_9_41_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13063-017-2413-6"},{"key":"e_1_2_9_42_1","doi-asserted-by":"publisher","DOI":"10.3233\/JAD-190146"},{"key":"e_1_2_9_43_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.18.00205"},{"key":"e_1_2_9_44_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.eururo.2017.04.036"},{"issue":"4","key":"e_1_2_9_45_1","first-page":"112","article-title":"Obstacles to the Accrual of Patients to Clinical Trials in the Community Setting","volume":"21","author":"Winn R. J.","year":"1994","journal-title":"Seminars in Oncology"},{"key":"e_1_2_9_46_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clon.2020.01.029"},{"key":"e_1_2_9_47_1","doi-asserted-by":"crossref","DOI":"10.1136\/bmj-2024-079474","article-title":"The Future of the NHS Depends on Its Workforce","volume":"384","author":"Dixon\u2010Woods M.","year":"2024","journal-title":"BMJ"},{"key":"e_1_2_9_48_1","doi-asserted-by":"publisher","DOI":"10.1186\/1745-6215-16-3"},{"key":"e_1_2_9_49_1","doi-asserted-by":"publisher","DOI":"10.1200\/JOP.2016.013060"},{"key":"e_1_2_9_50_1","doi-asserted-by":"publisher","DOI":"10.1200\/CCI.22.00179"},{"key":"e_1_2_9_51_1","doi-asserted-by":"publisher","DOI":"10.1093\/jamia\/ocae244"},{"key":"e_1_2_9_52_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10238-022-00975-1"},{"key":"e_1_2_9_53_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jbi.2009.12.004"},{"key":"e_1_2_9_54_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12911-015-0149-3"},{"key":"e_1_2_9_55_1","doi-asserted-by":"publisher","DOI":"10.4137\/CIN.S19454"},{"key":"e_1_2_9_56_1","doi-asserted-by":"publisher","DOI":"10.1111\/jep.13583"}],"container-title":["Cancer Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/cam4.70466","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,2,19]],"date-time":"2025-02-19T04:55:18Z","timestamp":1739940918000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/cam4.70466"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,12]]},"references-count":55,"journal-issue":{"issue":"23","published-print":{"date-parts":[[2024,12]]}},"alternative-id":["10.1002\/cam4.70466"],"URL":"https:\/\/doi.org\/10.1002\/cam4.70466","archive":["Portico"],"relation":{},"ISSN":["2045-7634","2045-7634"],"issn-type":[{"value":"2045-7634","type":"print"},{"value":"2045-7634","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,12]]},"assertion":[{"value":"2024-10-04","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-11-24","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-12-03","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e70466"}}