{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,19]],"date-time":"2026-09-19T16:17:00Z","timestamp":1789834620902,"version":"4.0.1"},"reference-count":25,"publisher":"Wiley","issue":"23","license":[{"start":{"date-parts":[[2024,12,11]],"date-time":"2024-12-11T00:00:00Z","timestamp":1733875200000},"content-version":"vor","delay-in-days":10,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100012151","name":"Sanming Project of Medicine in Shenzen Municipality","doi-asserted-by":"publisher","award":["SZSM201911020"],"award-info":[{"award-number":["SZSM201911020"]}],"id":[{"id":"10.13039\/501100012151","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81970339"],"award-info":[{"award-number":["81970339"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82370389"],"award-info":[{"award-number":["82370389"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cancer Medicine"],"published-print":{"date-parts":[[2024,12]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:title>Aims<\/jats:title><jats:p>This study aimed to investigate the clinical value of the glucose\u2010albumin ratio (GAR) in predicting the prognosis of cancer patients prescribed anthracycline\u2010based chemotherapy.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We included cancer patients who underwent anthracycline\u2010based chemotherapy, drawn from the population\u2010based cohort Clinical Data Analysis Reporting System of Hong Kong between January 2000 and December 2019. Demographics, medical history, baseline laboratory, and metabolic indicators, including GAR, were collected. We employed random survival forests (RSF) with the variable importance (VIMP) method to rank the importance of these variables. Cox proportional hazards regression was used to assess the association between GAR levels and event risks.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A total of 18,700 patients were included in the analysis. The top 2 factors for predicting overall cardiovascular event risk were GAR and fasting blood glucose (FBG). Our results revealed that a higher GAR was significantly associated with poorer cardiovascular prognosis in patients with cancer prescribed with anthracycline\u2010based chemotherapy. Compared to the lowest quartile, higher GAR levels were significantly associated with increased risk of all\u2010cause mortality, major adverse cardiovascular events, hospitalization of heart failure, and cardiovascular mortality regardless of the adjustments (all <jats:italic>p<\/jats:italic> trend &lt;\u20090.001).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>GAR is a potential biomarker for predicting the prognosis of cancer patients undergoing anthracycline\u2010based chemotherapy. Monitoring GAR levels before and during treatment may help identify patients at higher risk of adverse outcomes, facilitating personalized treatment strategies and improving clinical management.<\/jats:p><\/jats:sec>","DOI":"10.1002\/cam4.70471","type":"journal-article","created":{"date-parts":[[2024,12,11]],"date-time":"2024-12-11T16:58:21Z","timestamp":1733936301000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Prognosis Prediction of Cardiovascular Event With Glucose\u2010Albumin Ratio on Patients With Cancer and Prescribed With Anthracycline"],"prefix":"10.1002","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9950-9696","authenticated-orcid":false,"given":"Iokfai","family":"Cheang","sequence":"first","affiliation":[{"name":"State Key Laboratory for Innovation and Transformation of Luobing Theory, Department of Cardiology The First Affiliated Hospital of Nanjing Medical University, Jiangsu Province Hospital  Nanjing China"},{"name":"Division of Cardiology, Department of Medicine The University of Hong Kong \u2010 Shenzhen Hospital  Shenzhen China"},{"name":"Cardiology Division, Department of Medicine The University of Hong Kong, Queen Mary Hospital  Hong Kong China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ying","family":"Li","sequence":"additional","affiliation":[{"name":"State Key Laboratory for Innovation and Transformation of Luobing Theory, Department of Cardiology The First Affiliated Hospital of Nanjing Medical University, Jiangsu Province Hospital  Nanjing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xu","family":"Zhu","sequence":"additional","affiliation":[{"name":"State Key Laboratory for Innovation and Transformation of Luobing Theory, Department of Cardiology The First Affiliated Hospital of Nanjing Medical University, Jiangsu Province Hospital  Nanjing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ziqi","family":"Chen","sequence":"additional","affiliation":[{"name":"State Key Laboratory for Innovation and Transformation of Luobing Theory, Department of Cardiology The First Affiliated Hospital of Nanjing Medical University, Jiangsu Province Hospital  Nanjing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qing\u2010Wen","family":"Ren","sequence":"additional","affiliation":[{"name":"Division of Cardiology, Department of Medicine The University of Hong Kong \u2010 Shenzhen Hospital  Shenzhen China"},{"name":"Cardiology Division, Department of Medicine The University of Hong Kong, Queen Mary Hospital  Hong Kong China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mei\u2010Zhen","family":"Wu","sequence":"additional","affiliation":[{"name":"Division of Cardiology, Department of Medicine The University of Hong Kong \u2010 Shenzhen Hospital  Shenzhen 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