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Patients were divided into a high\u2010clinical\u2010risk group (<jats:italic>n<\/jats:italic>\u2009=\u200936) and a low\u2010clinical\u2010risk group (<jats:italic>n<\/jats:italic>\u2009=\u200912) according to the mean time to metastatic relapse.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The analysis of Nanostring nCounter Panel data revealed differential expression of 42 genes between high\u2010clinical\u2010risk and low\u2010clinical\u2010risk groups. All the genes except for <jats:italic>NR4A1<\/jats:italic> and <jats:italic>FOS<\/jats:italic> were upregulated in the high\u2010clinical\u2010risk group. A general overexpression of apoptosis, PI3K and MAPK pathway\u2010related genes, including AKT2, was observed in the high\u2010clinical\u2010risk group.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The differential genetic signature identified between the two study groups revealed novel biomarkers in mHSPC, additionally suggesting new therapeutic targets within the hormone sensitive phase, such as <jats:italic>AKT2<\/jats:italic>. Further prospective larger cohort studies are needed to assess the prognostic value of our findings and their exact role in prostate cancer progression.<\/jats:p><\/jats:sec>","DOI":"10.1002\/cam4.70472","type":"journal-article","created":{"date-parts":[[2025,2,21]],"date-time":"2025-02-21T05:35:30Z","timestamp":1740116130000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["A Novel Molecular Profile of Hormone\u2010Sensitive Prostate Cancer Defines High Risk Patients"],"prefix":"10.1002","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7224-4536","authenticated-orcid":false,"given":"Claudia","family":"Piombino","sequence":"first","affiliation":[{"name":"Division of Oncology, Department of Oncology and Hematology University Hospital of Modena  Modena Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cecilia","family":"Nasso","sequence":"additional","affiliation":[{"name":"Division of Oncology S. 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