{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,25]],"date-time":"2026-08-25T16:23:53Z","timestamp":1787675033685,"version":"build-2784847793"},"reference-count":25,"publisher":"Wiley","issue":"23","license":[{"start":{"date-parts":[[2024,12,10]],"date-time":"2024-12-10T00:00:00Z","timestamp":1733788800000},"content-version":"vor","delay-in-days":9,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cancer Medicine"],"published-print":{"date-parts":[[2024,12]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Mogamulizumab is a monoclonal antibody targeting the C\u2010C chemokine receptor 4, used to treat T\u2010cell malignancies such as cutaneous T\u2010cell lymphoma, adult T\u2010cell leukemia\/lymphoma, and peripheral T\u2010cell lymphoma. However, real\u2010world studies on mogamulizumab\u2010associated adverse events (AEs) are limited.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Disproportionality analyses were performed to assess the safety profile of mogamulizumab based on data from the US Food and Drug Administration Adverse Event Reporting System (FAERS) database for the period spanning from October 2018 to December 2023. The research investigated demographic characteristics, the onset timing of AEs, and the safety implications associated with mogamulizumab use.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A total of 1182 significant preferred terms were identified among the 3661 mogamulizumab\u2010associated AE reports collected from the FAERS database. The frequently reported AEs including rash, infusion\u2010related reaction, and pyrexia were in line with drug instruction. Notably, several unexpectedly significant AEs were also found, including pemphigoid (ROR\u2009=\u20095.69 [95% CI 1.83\u201317.66]), unstable angina (ROR\u2009=\u200920.56 [95% CI 8.54\u201349.5]), bulbar palsy (ROR\u2009=\u2009238.36 [95% CI 75.22\u2013755.31]), myositis (ROR\u2009=\u200912.65 [95% CI 5.67\u201328.19]), and various autoimmune diseases such as autoimmune hepatitis (ROR\u2009=\u200921.33 [95% CI 11.08\u201341.07]), myocarditis (ROR\u2009=\u200915.29 [95% CI 8.67\u201326.97]), glomerulonephritis (ROR\u2009=\u200922.49 [95% CI 7.24\u201369.9]), nephrotic syndrome (ROR\u2009=\u20097.63 [95% CI 2.46\u201323.67]), myasthenia gravis (ROR\u2009=\u20098.54 [95% CI 3.2\u201322.77]), and autoimmune thyroiditis (ROR\u2009=\u200911.81 [95% CI 3.8\u201336.68]).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>This study replicated previously identified AEs associated with mogamulizumab and uncovered additional signals of AEs, particularly emphasizing the risks associated with autoimmune diseases. It is essential to exercise vigilance in monitoring the occurrence of these AEs during the use of mogamulizumab in clinical practice.<\/jats:p><\/jats:sec>","DOI":"10.1002\/cam4.70478","type":"journal-article","created":{"date-parts":[[2024,12,11]],"date-time":"2024-12-11T06:54:38Z","timestamp":1733900078000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Mogamulizumab\u2010Associated Autoimmune Diseases: Insights From <scp>FAERS<\/scp> Database Analysis"],"prefix":"10.1002","volume":"13","author":[{"given":"Genshan","family":"Zhang","sequence":"first","affiliation":[{"name":"Department of Gastrointestinal Surgery, Tongji Hospital, Tongji Medical College Huazhong University of Science and Technology  Wuhan People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haokun","family":"Zhang","sequence":"additional","affiliation":[{"name":"School of Public Health and Health Management 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