{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T04:00:55Z","timestamp":1792036855887,"version":"4.4.0"},"reference-count":10,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2024,4,23]],"date-time":"2024-04-23T00:00:00Z","timestamp":1713830400000},"content-version":"vor","delay-in-days":22,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cancer Medicine"],"published-print":{"date-parts":[[2024,4]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Multiple myeloma (MM), an incurable disease characterized by frequent relapses and a need for multiple treatments, often progresses to a relapse\/refractory status resistant to all available drugs and drug classes. Bispecific antibodies, specifically BCMA T\u2010cell engagers, have emerged as effective treatments for MM, demonstrating impressive efficacy. However, these treatments can adversely affect the immune system, increasing vulnerability to infections.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods\/Results<\/jats:title>\n                    <jats:p>This study evaluated the efficacy and safety of BCMA T\u2010cell engagers in 58 Swedish patients with poor MM prognosis. The patients exhibited a 69% overall response rate, with 69% survival and 60% progression\u2010free survival at 15\u2009months.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Despite the risk of infectious complications, the prognosis of MM patients can be significantly improved with vigilant monitoring and proactive management of infections. This real\u2010world data highlight the potential of BCMA T\u2010cell engagers in treating MM, emphasizing the need for careful patient monitoring to mitigate infection risks.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/cam4.7048","type":"journal-article","created":{"date-parts":[[2024,4,23]],"date-time":"2024-04-23T03:38:19Z","timestamp":1713843499000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["Effectiveness and infectious complications of\n                    <scp>BCMA T\u2010cell<\/scp>\n                    engagers in treating multiple myeloma:\n                    <scp>Real\u2010world<\/scp>\n                    evidence from Sweden"],"prefix":"10.1002","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9786-6876","authenticated-orcid":false,"given":"Katarina","family":"Uttervall","sequence":"first","affiliation":[{"name":"Center for Hematology and Regenerative Medicine, Department of Medicine, Huddinge Karolinska Institutet  Stockholm Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8205-4712","authenticated-orcid":false,"given":"Love","family":"T\u00e4tting","sequence":"additional","affiliation":[{"name":"Department of Haematology in Link\u00f6ping, and Department of Biomedical and Clinical Sciences Link\u00f6ping University  Link\u00f6ping Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Konstantinos","family":"Lemonakis","sequence":"additional","affiliation":[{"name":"Department of Hematology Lund University  Lund Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mousa","family":"Majd","sequence":"additional","affiliation":[{"name":"Center for Hematology and Regenerative Medicine, Department of Medicine, Huddinge Karolinska Institutet  Stockholm Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jacob","family":"Crafoord","sequence":"additional","affiliation":[{"name":"Department of Medicine Orebro University Hospital  Orebro Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mikael","family":"Olsson","sequence":"additional","affiliation":[{"name":"Section of Hematology Department of Internal Medicine Hallands Sjukhus Varberg  Varberg Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ulf\u2010Henrik","family":"Mellqvist","sequence":"additional","affiliation":[{"name":"Section of Hematology and Coagulation, Department of Medicine Sahlgrenska University Hospital  Gothenburg Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Markus","family":"Hansson","sequence":"additional","affiliation":[{"name":"Section of Hematology and Coagulation, Department of Medicine Sahlgrenska University Hospital  Gothenburg Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hareth","family":"Nahi","sequence":"additional","affiliation":[{"name":"Center for Hematology and Regenerative Medicine, Department of Medicine, Huddinge Karolinska Institutet  Stockholm Sweden"},{"name":"Department of Haematology in Link\u00f6ping, and Department of Biomedical and Clinical Sciences Link\u00f6ping University  Link\u00f6ping Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,4,23]]},"reference":[{"key":"e_1_2_12_2_1","doi-asserted-by":"publisher","DOI":"10.1038\/leu.2017.138"},{"key":"e_1_2_12_3_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.leu.2404444"},{"key":"e_1_2_12_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajh.26207"},{"key":"e_1_2_12_5_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41591-023-02528-9"},{"key":"e_1_2_12_6_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa2203478"},{"key":"e_1_2_12_7_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41375-019-0435-7"},{"key":"e_1_2_12_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejca.2016.07.025"},{"key":"e_1_2_12_9_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0211927"},{"key":"e_1_2_12_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/ejh.12551"},{"key":"e_1_2_12_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1470-2045(23)00159-6"}],"container-title":["Cancer 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