{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,30]],"date-time":"2025-07-30T08:06:44Z","timestamp":1753862804996,"version":"3.41.2"},"reference-count":41,"publisher":"Wiley","issue":"24","license":[{"start":{"date-parts":[[2024,12,22]],"date-time":"2024-12-22T00:00:00Z","timestamp":1734825600000},"content-version":"vor","delay-in-days":21,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cancer Medicine"],"published-print":{"date-parts":[[2024,12]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:title>Aims<\/jats:title><jats:p>To evaluate antibody response to mRNA vaccine, identify subgroups with poor response and to determine long\u2010term antibody durability in hematological patients.<\/jats:p><\/jats:sec><jats:sec><jats:title>Materials and Methods<\/jats:title><jats:p>We have vaccinated 292 patients with all hematological malignancies with a third dose of mRNA COMIRNATY vaccine with a 12\u2010month follow\u2010up period in our center in Ostrava, Czech Republic.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Antibody response for the whole cohort exceeded 74% through the whole 12\u2010month follow\u2010up. Lowest seroconversion was observed in CLL cohort (20\/41, 48.8%), patients who received anti\u2010CD20 therapy\u2009&lt;\u20096\u2009months before vaccination (8\/30, 26.7%) and BTK inhibitors (3\/6, 50.0%). On the contrary, patients with chronic myeloproliferative neoplasms and acute leukemia performed comparably with healthy population (33\/33; 100% and 12\/13; 92.3%, respectively). We have seen better results if the time interval between anti\u2010CD20 therapy and additional vaccine dose was longer than 6\u2009months (5\/8 patients achieved seroconversion on 4th booster dose after previous failure). Also, 36 patients received a 4th dose of vaccine as a booster with measurable increase in protective antibodies in 50% (18\/36).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Additional doses show promise for a well\u2010timed revaccination even in poor responders. To our knowledge, no study comparable to our work in terms of follow\u2010up length, vaccine consistency or variety of hematological malignancies and\/or treatment has been reported yet. Our findings shed more light on long\u2010term antibody response to mRNA vaccines against SARS\u2010CoV\u20102 in patients with hematological cancer and bring important data for the evaluation of possible vaccine failure and scheduling of subsequent doses.<\/jats:p><\/jats:sec>","DOI":"10.1002\/cam4.70503","type":"journal-article","created":{"date-parts":[[2024,12,23]],"date-time":"2024-12-23T07:42:49Z","timestamp":1734939769000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["One Year Duration of Immune Response Following a 3rd Booster Dose of mRNA Vaccine Against COVID\u201019 in 292 Patients With Hematological Malignancies in University Hospital Ostrava, Czech Republic"],"prefix":"10.1002","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7820-5987","authenticated-orcid":false,"given":"Ondrej","family":"\u0160u\u0161ol","sequence":"first","affiliation":[{"name":"Department of Haemato\u2010Oncology 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