{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,7]],"date-time":"2026-07-07T20:14:39Z","timestamp":1783455279213,"version":"3.55.0"},"reference-count":26,"publisher":"Wiley","issue":"24","license":[{"start":{"date-parts":[[2024,12,18]],"date-time":"2024-12-18T00:00:00Z","timestamp":1734480000000},"content-version":"vor","delay-in-days":17,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82270177"],"award-info":[{"award-number":["82270177"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cancer Medicine"],"published-print":{"date-parts":[[2024,12]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:title>Backgroud<\/jats:title><jats:p>The high cost of blinatumomab in full doses of full treatments has led to dose reduction and fewer treatment cycles for most patients in China. With current needs for cost\u2010efficiency and resource management in health care, we retrospectively evaluated the clinical effects of short\u2010course blinatumomab treatment for R\/R Ph\u2010 B\u2010ALL at our center.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Blinatumomab was administered with 24\u2010h continuous intravenous infusion (9\u2009\u03bcg\/day for the first 3\u2009days and 28\u2009\u03bcg\/day for 6\u201310\u2009days). The clinical data of 30 R\/R B\u2010ALL patients were collected and analyzed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A total of 25 patients (83.3%) including 13 (43.3%) with a high leukemic load (&gt;\u200950%) achieved morphological CR. Twelve patients (40%) were MRD\u2010negative. The estimated 2\u2010year OS rate was 82.62%. The 2\u2010year PFS rate was 78.35%. The estimated 2\u2010year OS and PFS were significantly better in patients receiving further treatment.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Our findings provide novel insights into the optimization of blinatumomab therapy, proposing a viable treatment alternative that aligns with current needs for cost\u2010efficiency and resource management in health care.<\/jats:p><\/jats:sec>","DOI":"10.1002\/cam4.70515","type":"journal-article","created":{"date-parts":[[2024,12,18]],"date-time":"2024-12-18T12:21:51Z","timestamp":1734524511000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Short\u2010Course Blinatumomab Treatment as a Bridge to Further Salvage Therapy for Relapsed\/Refractory B\u2010Cell Acute Lymphoblastic Leukemia: A Retrospective Single\u2010Center Study"],"prefix":"10.1002","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7541-1176","authenticated-orcid":false,"given":"Jin","family":"Yin","sequence":"first","affiliation":[{"name":"Department of Hematology, Tongji Hospital, Tongji Medical College Huazhong University of Science and Technology  Wuhan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoya","family":"Cai","sequence":"additional","affiliation":[{"name":"Department of Hematology, Tongji Hospital, Tongji Medical College Huazhong University of Science and Technology  Wuhan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0009-3153-4308","authenticated-orcid":false,"given":"Bingxin","family":"Qian","sequence":"additional","affiliation":[{"name":"Department of Hematology, Tongji Hospital, Tongji Medical College Huazhong University of Science and Technology  Wuhan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ying","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Hematology, Tongji Hospital, Tongji Medical College Huazhong University of Science and Technology  Wuhan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dengju","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Hematology, Tongji Hospital, Tongji Medical College Huazhong University of Science and Technology  Wuhan 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