{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,12]],"date-time":"2026-10-12T21:28:07Z","timestamp":1791840487765,"version":"4.3.4"},"reference-count":33,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2025,1,6]],"date-time":"2025-01-06T00:00:00Z","timestamp":1736121600000},"content-version":"vor","delay-in-days":5,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001826","name":"ZonMw","doi-asserted-by":"publisher","award":["2016\/04981\/ZONMW\u201091101002"],"award-info":[{"award-number":["2016\/04981\/ZONMW\u201091101002"]}],"id":[{"id":"10.13039\/501100001826","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cancer Medicine"],"published-print":{"date-parts":[[2025,1]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Inflammation has been reported to drive cancer\u2010related fatigue (CRF). As both obesity and chemotherapy promote inflammatory responses, obese cancer patients may be at risk of more severe CRF, especially when receiving chemotherapy.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We analysed data of 333 colon cancer patients from four hospitals in the Netherlands (data derived from the PROCORE study). Fatigue was assessed with the general fatigue subscale of the Multidimensional Fatigue Inventory at four timepoints: at inclusion (T1), 4\u2009weeks after surgery (T2), and 1 (T3) and 2\u2009years (T4) after diagnosis. Linear mixed\u2010effects models were applied to evaluate the interaction between chemotherapy and body mass index (BMI) on the trajectory of fatigue.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      The two\u2010way interactions between time and chemotherapy (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.047) and between time and BMI on fatigue (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.041) were significant. Patients scheduled for chemotherapy reported more fatigue during the treatment phase, while patients not treated with chemotherapy showed a stable trajectory. Obese patients reported more fatigue at follow\u2010up compared to patients with a healthy BMI. The three\u2010way interaction between time, chemotherapy and BMI was not significant (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.39). However, obese chemotherapy\u2010treated patients reported the highest fatigue 2\u2009years after treatment (12.8, 95% CI: 10.6\u201314.9). Their mean fatigue score was higher compared to baseline (9.2, 95% CI: 7.3\u201311.0,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001) and obese patients not treated with chemotherapy (9.6, 95% CI: 7.0\u201312.2,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.02). Moreover, this group reported more fatigue compared to healthy (8.1, 95% CI: 5.5\u201310.9,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001) and overweight (9.7, 95% CI: 7.2\u201312.3,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.019) chemotherapy\u2010treated patients.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>This study indicates that chemotherapy and BMI both influence long\u2010term fatigue in colon cancer patients. Proactive monitoring for CRF and lifestyle interventions may be needed for chemotherapy\u2010treated patients with a high BMI.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/cam4.70536","type":"journal-article","created":{"date-parts":[[2025,1,6]],"date-time":"2025-01-06T03:02:32Z","timestamp":1736132552000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["The Impact of Chemotherapy and Body Mass Index on Cancer\u2010Related Fatigue in Colon Cancer Patients: A\n                    <scp>PROFILES<\/scp>\n                    \u2010Registry Study"],"prefix":"10.1002","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9099-5050","authenticated-orcid":false,"given":"Anneke","family":"Kastelein","sequence":"first","affiliation":[{"name":"Department of Cell and Chemical Biology, ONCODE Institute Leiden University Medical Center  Leiden the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0818-2913","authenticated-orcid":false,"given":"Floortje","family":"Mols","sequence":"additional","affiliation":[{"name":"CoRPS \u2010 Center of Research on Psychological Disorders and Somatic Diseases, Department of Medical and Clinical Psychology Tilburg University  Tilburg the Netherlands"},{"name":"Netherlands Comprehensive Cancer Organisation (IKNL)  Utrecht the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6062-9164","authenticated-orcid":false,"given":"Laura","family":"Kervezee","sequence":"additional","affiliation":[{"name":"Laboratory for Neurophysiology, Department of Cell and Chemical Biology Leiden University Medical Center  Leiden the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8607-9199","authenticated-orcid":false,"given":"Niels H.","family":"Chavannes","sequence":"additional","affiliation":[{"name":"Department of Public Health and Primary Care Leiden University Medical Center  Leiden the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9270-8636","authenticated-orcid":false,"given":"Hans","family":"Gelderblom","sequence":"additional","affiliation":[{"name":"Department of Medical Oncology Leiden University Medical Center  Leiden the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6763-2211","authenticated-orcid":false,"given":"Jacques","family":"Neefjes","sequence":"additional","affiliation":[{"name":"Department of Cell and Chemical Biology, ONCODE Institute Leiden University Medical Center  Leiden the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6085-4065","authenticated-orcid":false,"given":"Chris","family":"Hinnen","sequence":"additional","affiliation":[{"name":"Department of Psycho\u2010Oncology LUMC Oncology Center  Leiden the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,1,6]]},"reference":[{"key":"e_1_2_13_2_1","doi-asserted-by":"publisher","DOI":"10.3322\/CAAC.21660"},{"key":"e_1_2_13_3_1","unstructured":"Netherlands Comprehensive Cancer Organisation (IKNL) Netherlands Cancer Registery (NCR) 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