{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,20]],"date-time":"2026-10-20T16:17:36Z","timestamp":1792513056580,"version":"4.5.0"},"reference-count":37,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2025,2,25]],"date-time":"2025-02-25T00:00:00Z","timestamp":1740441600000},"content-version":"vor","delay-in-days":24,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100005205","name":"Janssen Research and Development","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100005205","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cancer Medicine"],"published-print":{"date-parts":[[2025,2]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Somatic <jats:italic>FGFR<\/jats:italic> gene alterations (<jats:italic>FGFRalt<\/jats:italic>) may act as oncogenic drivers across several cancers. The prognostic impact of <jats:italic>FGFRalt<\/jats:italic> in solid tumors is not fully understood. We assessed the prognostic impact of <jats:italic>FGFRalt<\/jats:italic> on overall survival (OS) in a tumor\u2010agnostic real\u2010world cohort of patients with advanced solid tumors.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This was a retrospective, observational, comparative cohort analysis that used data from a nationwide de\u2010identified clinico\u2010genomic database. Patients were included if they had advanced\/metastatic disease, were aged\u2009\u2265\u200918\u2009years at the time of diagnosis, had evidence of genomic testing for <jats:italic>FGFRalt<\/jats:italic>, and had initiated first\u2010line systemic therapy for their cancer. Patients without <jats:italic>FGFR<\/jats:italic> alterations (<jats:italic>FGFRneg<\/jats:italic>) were matched 3:1 with patients with <jats:italic>FGFRalt<\/jats:italic> using a combination of exact matching on tumor type and Mahalanobis\u2010distance matching on selected clinical confounders. The primary endpoint was OS from time of initiation of first\u2010line therapy in patients with <jats:italic>FGFRalt<\/jats:italic> versus <jats:italic>FGFRneg<\/jats:italic>. To further mitigate bias, delayed entry models and covariate\u2010adjusted stratified Cox models were implemented.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The final cohort included 1012 patients (253 <jats:italic>FGFRalt<\/jats:italic>, 759 <jats:italic>FGFRneg<\/jats:italic>), across 30 tumor types. There were no significant differences in real\u2010world OS from first\u2010line therapy between <jats:italic>FGFRalt<\/jats:italic> and <jats:italic>FGFRneg<\/jats:italic> groups (hazard ratio 0.97; <jats:italic>p<\/jats:italic>\u2009=\u20090.78). Median OS from initiation of first\u2010line therapy was 1.13\u2009years (95% confidence interval [CI] 0.92\u20131.52) and 1.01\u2009years (0.89\u20131.15) for the <jats:italic>FGFRalt<\/jats:italic> and <jats:italic>FGFRneg<\/jats:italic> groups, respectively.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>In this matched\u2010cohort real\u2010world analysis, presence of <jats:italic>FGFRalt<\/jats:italic> had no impact on the prognosis of patients with advanced solid tumors receiving standard\u2010of\u2010care treatment.<\/jats:p><\/jats:sec>","DOI":"10.1002\/cam4.70546","type":"journal-article","created":{"date-parts":[[2025,2,26]],"date-time":"2025-02-26T09:03:01Z","timestamp":1740560581000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Prognostic Impact of Oncogenic Fibroblast Growth Factor Receptor Alterations in Patients With Advanced Solid Tumors in a Real\u2010World Setting"],"prefix":"10.1002","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1854-3658","authenticated-orcid":false,"given":"Levon","family":"Demirdjian","sequence":"first","affiliation":[{"name":"Janssen Research &amp; 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Development  Spring House Pennsylvania USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joel","family":"Greshock","sequence":"additional","affiliation":[{"name":"Janssen Research &amp; Development  Spring House Pennsylvania USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julie","family":"Paone","sequence":"additional","affiliation":[{"name":"Aetion  New York New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paige","family":"Sheridan","sequence":"additional","affiliation":[{"name":"Aetion  New York New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9281-480X","authenticated-orcid":false,"given":"Shubham","family":"Pant","sequence":"additional","affiliation":[{"name":"The University of Texas, MD Anderson Cancer Center  Houston Texas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5505-0564","authenticated-orcid":false,"given":"Christophe","family":"Massard","sequence":"additional","affiliation":[{"name":"Gustave Roussy Universit\u00e9 Paris Saclay  Villejuif France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David A.","family":"Reardon","sequence":"additional","affiliation":[{"name":"Dana\u2010Farber Cancer Institute and Harvard Medical School  Boston Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yohann","family":"Loriot","sequence":"additional","affiliation":[{"name":"Gustave Roussy Universit\u00e9 Paris Saclay  Villejuif France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martin","family":"Schuler","sequence":"additional","affiliation":[{"name":"West German Cancer Center University Hospital Essen  Essen Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hussein","family":"Sweiti","sequence":"additional","affiliation":[{"name":"Janssen Research &amp; 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