{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,30]],"date-time":"2025-07-30T08:06:22Z","timestamp":1753862782369,"version":"3.41.2"},"reference-count":31,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2025,1,27]],"date-time":"2025-01-27T00:00:00Z","timestamp":1737936000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82260030,82260043"],"award-info":[{"award-number":["82260030,82260043"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cancer Medicine"],"published-print":{"date-parts":[[2025,2]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Bilirubin has anti\u2010inflammatory, antioxidant, and anti\u2010cancer properties, with an inverse relationship between its levels and cancer risk and prognosis. However, the prognostic value of serum bilirubin in acute myeloid leukemia (AML) remains uncertain.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This retrospective study analyzed pretreatment serum total bilirubin (TBIL), direct bilirubin (DBIL), and indirect bilirubin (IBIL) in 284 AML patients and 316 healthy controls. The prognostic significance of serum bilirubin levels was determined using the Kaplan\u2013Meier method and Cox proportional hazards model.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Pretreatment TBIL and IBIL levels were significantly lower in AML patients compared to controls. TBIL and IBIL levels were significantly higher in the CR\/CRh\/CRi group than in the non\u2010CR\/CRh\/CRi group and increased significantly after chemotherapy. Elevated pretreatment TBIL and IBIL were associated with longer overall survival (OS) (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.05) and progression\u2010free survival (PFS) (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.05). Pretreatment IBIL was an independent prognostic factor for OS (hazard ratio [HR], 0.47; 95% confidence interval [CI] 0.28\u20130.79; <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.05) and PFS (HR, 0.53; 95% CI 0.33\u20130.85; <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.05).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Elevated pretreatment IBIL levels are correlated with improved OS and PFS, acting as an independent favorable prognostic indicator for AML.<\/jats:p><\/jats:sec>","DOI":"10.1002\/cam4.70572","type":"journal-article","created":{"date-parts":[[2025,1,27]],"date-time":"2025-01-27T13:56:14Z","timestamp":1737986174000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Association of Pretreatment Serum Indirect Bilirubin Levels With Prognostic and Therapeutic Value in Patients With Newly Diagnosed Acute Myeloid Leukemia"],"prefix":"10.1002","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1703-324X","authenticated-orcid":false,"given":"Chunfang","family":"Kong","sequence":"first","affiliation":[{"name":"Department of Hematology The Second Affiliated Hospital, Jiangxi Medical College, Nanchang University  Nanchang Jiangxi China"},{"name":"Department of Hematology Jiangxi Provincial People's Hospital, the First Affiliated Hospital of Nanchang Medical College  Nanchang Jiangxi China"},{"name":"Jiangxi Provincial Key Laboratory of Hematological Diseases  Nanchang Jiangxi China"},{"name":"National Clinical Research Center for Hematologic Diseases The First Affiliated Hospital of Soochow University  Nanjing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1990-4523","authenticated-orcid":false,"given":"Linhui","family":"Hu","sequence":"additional","affiliation":[{"name":"Department of Hematology The Second Affiliated Hospital, 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