{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,25]],"date-time":"2026-06-25T05:42:33Z","timestamp":1782366153710,"version":"3.54.5"},"reference-count":32,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2025,1,2]],"date-time":"2025-01-02T00:00:00Z","timestamp":1735776000000},"content-version":"vor","delay-in-days":1,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82170208"],"award-info":[{"award-number":["82170208"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012166","name":"National Key Research and Development Program of China","doi-asserted-by":"publisher","award":["2022YFC2502606"],"award-info":[{"award-number":["2022YFC2502606"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cancer Medicine"],"published-print":{"date-parts":[[2025,1]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>This study compares the efficacy and safety of single autologous stem cell transplantation (ASCT) versus tandem ASCT for multiple myeloma (MM) patients in the era of novel agents.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      A total of 112 high\u2010risk MM patients were included (single ASCT,\n                      <jats:italic>(n<\/jats:italic>\n                      \u2009=\u200957) or tandem ASCT\n                      <jats:italic>(n<\/jats:italic>\n                      \u2009=\u200955) in this retrospective multicenter study. Responses and outcomes were evaluated.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      At 100\u2009days after ASCT1 and ASCT2, 36 (63.2%) versus 45 (81.8%) patients achieved sCR\/CR, 16 (28.1%) versus 7 (12.7%) patients achieved VGPR, and 5 (8.8%) versus 1 (1.8%) patient achieved PR, respectively, in the single and tandem ASCT cohorts. The 3\u2010year cumulative incidence of non\u2010relapse mortality and disease progression was 0% versus 7.3% (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.083), and 45.8% versus 25.8% (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.039), respectively, for the single and tandem ASCT cohort. The tandem ASCT cohort showed a trend of better 3\u2010year probability of PFS (58.1% vs. 64.7%,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.064) compared with the single ASCT cohort. In multivariate analysis, ultra high\u2010risk and achieving&lt;VGPR response after ASCT1 were associated with an inferior PFS. Ultra high\u2010risk was also associated with an inferior OS.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Tandem ASCT demonstrated improved outcomes compared to single ASCT in high\u2010risk MM patients receiving triplet or quadruplet induction and maintenance therapy. However, patients with ultra high\u2010risk cytogenetics may require innovative therapeutic approaches, as tendem ASCT does not overcome their adverse prognosis.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/cam4.70573","type":"journal-article","created":{"date-parts":[[2025,1,2]],"date-time":"2025-01-02T05:45:36Z","timestamp":1735796736000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Tandem Versus Single Autologous Stem Cell Transplantation for High\u2010Risk Multiple Myeloma in the Era\u00a0of Novel Agents: A Real\u2010World Study of China"],"prefix":"10.1002","volume":"14","author":[{"given":"Xuelin","family":"Dou","sequence":"first","affiliation":[{"name":"Peking University People's Hospital, Peking University Institute of Hematology, National Clinical Research Center for Hematologic Disease, Beijing Key Laboratory of Hematopoietic Stem Cell Transplantation Peking University  Beijing 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Hematologic Disease, Beijing Key Laboratory of Hematopoietic Stem Cell Transplantation Peking University  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lei","family":"Wen","sequence":"additional","affiliation":[{"name":"Peking University People's Hospital, Peking University Institute of Hematology, National Clinical Research Center for Hematologic Disease, Beijing Key Laboratory of Hematopoietic Stem Cell Transplantation Peking University  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leqing","family":"Cao","sequence":"additional","affiliation":[{"name":"Peking University People's Hospital, Peking University Institute of Hematology, National Clinical Research Center for Hematologic Disease, Beijing Key Laboratory of Hematopoietic Stem Cell Transplantation Peking University  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yang","family":"Liu","sequence":"additional","affiliation":[{"name":"Peking University People's Hospital, Peking University Institute of Hematology, National Clinical Research Center for Hematologic Disease, Beijing Key Laboratory of Hematopoietic Stem Cell Transplantation Peking University  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8054-614X","authenticated-orcid":false,"given":"Daoxing","family":"Deng","sequence":"additional","affiliation":[{"name":"Peking University People's Hospital, Peking University Institute of Hematology, National Clinical Research Center for Hematologic Disease, Beijing Key Laboratory of Hematopoietic Stem Cell Transplantation Peking University  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fengrong","family":"Wang","sequence":"additional","affiliation":[{"name":"Peking University People's Hospital, Peking University Institute of Hematology, National Clinical Research Center for Hematologic Disease, Beijing Key Laboratory of Hematopoietic Stem Cell Transplantation Peking University  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liru","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Hematology, Fu Xing Hospital Capital Medical University  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8166-0216","authenticated-orcid":false,"given":"Hui","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Hematology, Beijing Hospital, National Center of Gerontology Institute of Geriatric Medicine, Chinese Academy of Medical Sciences  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaojun","family":"Huang","sequence":"additional","affiliation":[{"name":"Peking University People's Hospital, Peking University 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