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Their real\u2010world impacts need to be assessed over the long term.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>EMMY is a non\u2010interventional, prospective dynamic cohort, conducted in France, since 2017, with 900 patients enrolled each year. Newly diagnosed MM (NDMM) who initiated a treatment from 2017 to 2020 are here described.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A total of 1036 non\u2010transplant eligible (NTE) patients (median age: 74.9\u2009years) and 561 patients who received autologous stem cell transplantation (ASCT) (median age: 60.6\u2009years) were enrolled. For ASCT patients, a shift in induction treatment from bortezomib\u2010thalidomide\u2010dexamethasone (VTd) (29.1%) to bortezomib\u2010lenalidomide\u2010dexamethasone (VRd) (55.1%) marked the period. Maintenance treatment with R after ASCT became a standard (75% of patients). In NTE patients, R\u2010based regimens were increasingly used from 29.4% in 2017 (of whom Rd.: 17.0%, VRd: 10.6%) to 73.3% in 2020 (of whom Rd.: 21.8%, VRd: 48.5%). Median progression\u2010free survival (mPFS) was 46.5\u2009months (95% CI: 37.8\u201350.6) and 18.7\u2009months (95% CI: 16.3\u201320.8) in ASCT and NTE patients, respectively. In the ASCT group, patients treated with and without R maintenance had a mPFS of 51.8 (95% CI: 44.1\u2013NA) and 29.6\u2009months (95% CI: 21.8\u201340.9), respectively. In the NTE group, the mPFS was 26.3 (95% CI: 21.9\u201330.9) and 14.6\u2009months (95% CI: 11.9\u201317.7) in patients who received an R\u2010based and non\u2010R\u2010based regimen, respectively. The estimated 48\u2010month overall survival rates were 89% (95% CI: 84.5\u201392.2) and 63% (95% CI: 58.5\u201367.1) for ASCT and NTE patients, respectively.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>The 2017\u20132020 period was marked by the expansion of R use in both NDMM ASCT and NTE patients.<\/jats:p><\/jats:sec>","DOI":"10.1002\/cam4.70619","type":"journal-article","created":{"date-parts":[[2025,3,15]],"date-time":"2025-03-15T07:00:35Z","timestamp":1742022035000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Real\u2010World Outcomes of Newly Diagnosed Multiple Myeloma Patients Treated Before the Era of Anti\u2010<scp>CD38<\/scp> Antibodies: The <scp>EMMY<\/scp> Cohort From 2017 to 2020"],"prefix":"10.1002","volume":"14","author":[{"given":"Laure","family":"Vincent","sequence":"first","affiliation":[{"name":"Department of Clinical Hematology Montpellier University Hospital 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